Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist

European Journal of Pharmacology

Volumn 325, Issue 2-3, 1997, Pages 253-261

  Cascieri, Margaret A ^a   Ber, Elzbieta ^a   Fong, Tung Ming ^a   Hale, Jeffrey J ^a   Tang, Frank ^a   Shiao, Lin Lin ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Sadowski, Sharon ^a   Tota, Michael R ^a   Strader, Catherine D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonism; Pseudo irreversible; Tachykinin NK1 receptor antagonist

Indexed keywords

2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 4 (3 OXO 1,2,4 TRIAZOL 5 YLMETHYL) 3 PHENYLMORPHOLINE; SUBSTANCE P; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; DRUG RECEPTOR BINDING; HAMSTER; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMALS; BACULOVIRIDAE; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; KINETICS; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SPODOPTERA; SUBSTANCE P;

EID: 0030979265     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00122-2     Document Type: Article

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