Endothelial cell markers in bone marrow transplant recipients with and without acute graft-versus-host disease

Bone Marrow Transplantation

Volumn 19, Issue 9, 1997, Pages 909-914

  Salat, C ^a   Holler, E ^a,b   Kolb, H J ^a,b   Pihusch, R ^a   Reinhardt, B ^a   Hiller, E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Hamatologikum der GSF Neuherberg   (Germany)

Author keywords

Endothelium; Graft versus host disease; Thrombomodulin; Von Willebrand factor

Indexed keywords

CELL MARKER; THROMBOMODULIN; VON WILLEBRAND FACTOR;

ADOLESCENT; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DAMAGE; CONDITIONING; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECIPIENT;

EID: 0030978820     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1700767     Document Type: Article

References (22)

1. Holler E, Kolb HJ, Hiller E et al. Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation. Blood 1989; 73: 2018-2024.
2. Seeber C, Hiller E, Holler E, Kolb HJ. Increased levels of tissue plasminogen activator (t-PA) and tissue plasminogen activator inhibitor (PAI) correlate with tumor necrosis factor α (TNFα)-release in patients suffering from microangiopathy following bone marrow transplantation (BMT). Thromb Res 1992; 66: 373-383.
3. Pearson JD. Markers of endothelial perturbation and damage. Br J Rheumatol 1993; 32: 651-652.
4. Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-4746.
5. Ishii H, Majerus PW. Thrombomodulin is present in human plasma and urine. J Clin Invest 1985; 76: 2178-2181.
6. Dittmann WA, Majerus PW. Structure and function of thrombomodulin: a natural anticoagulant. Blood 1990; 75: 329-336.
7. Ishii H, Nakano M, Tsubouchi J et al. Establishment of enzyme immunoassay of human thrombomodulin in plasma and urine using monoclonal antibodies. Thromb Haemostas 1990; 63: 157-162.
8. Takahashi H, Ito S, Hanano M et al. Circulating thrombomodulin as a novel endothelial cell marker: comparison of its behaviour with von Willebrand factor and tissue-type plasminogen activator. Am J Hematol 1992; 41: 32-39.
9. Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18: 295-304.
10. Zoja C, Furci L, Ghilardi F et al. Cyclosporin-induced endothelial cell toxicity. Transplantation 1986; 55: 455-462.
11. Baker DG, Krochak RJ. The response of the microvascular system to radiation: a review. Cancer Invest. 1989; 7: 287-294.
12. Lazo JS. Endothelial injury caused by antineoplastic agents. Biochem Pharmacol 1986; 35: 1919-1923.
13. Eissner G, Kohlhuber F, Grell M et al. Critical involvement of transmembrane tumor necrosis factor α in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood 1995; 86: 4184-4193.
14. Collins PW, Gutteridge CN, O'Driscoll A et al. Von Willebrand factor as a marker of endothelial cell activation following BMT. Bone Marrow Transplant 1992; 10: 499-506.
15. Testa S, Manna A, Porcellini A et al. Increased plasma level of vascular endothelial glycoprotein thrombomodulin as an early indicator of endothelial damage in bone marrow transplantation. Bone Marrow Transplant 1996; 18: 383-388.
16. Antin JH, Ferrara JLM. Cytokine dysregulation and acute graft versus host disease. Blood 1992; 80: 2964-2968.
17. Holler E, Kolb HJ, Möller A et al. Increased serum levels of tumor necrosis factor α precede major complications of bone marrow transplantation. Blood 1990; 75: 1011-1016.
18. Moore KL, Esmon CT, Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159-165.
19. Ishii H, Uchiyama H, Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemostas 1991; 65: 618-623.
20. Dumler JS, Beschorner WE, Farmer ER et al. Endothelial cell injury in cutaneous acute graft-versus-host disease. Am J Pathol 1989; 135: 1097-1103.
21. Sviland L, Sale GE, Myerson D. Endothelial changes in cutaneous graft-versus-host disease: a comparison between HLA matched and mismatched recipients of bone marrow transplantation. Bone Marrow Transplant 1991; 7: 35-38.
22. Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood 1990; 76: 2024-2029.