An expedient synthesis of (±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide via a 3-bromoisoxazole intermediate

Journal of Heterocyclic Chemistry

Volumn 34, Issue 1, 1997, Pages 345-348

  Hanson, Robert N ^a   Mohamed, Fand A ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (3 HYDROXY 5 METHYLISOXAZOL 4 YL)PROPIONIC ACID; ISOXAZOLE DERIVATIVE; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0030978577     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570340155     Document Type: Article

References (11)

1. J. J. Hansen, U. Madsen, E. O. Nielsen, B. Neilsen, L. Brehm, and P. Krogsgaard-Larsen, New Methods in Drug Research, Vol 3. A. Makryannis and J. R. Prous, eds, Science Publishers S. A., 1984 pp 73-101.
2. P. Krogsgaard-Larsen, Pharmacol. Toxicol., 70, 95 (1992).
3. J. J. Hansen and P. Krogsgaard-Larsen, J. Chem. Soc., Perkin Trans. I. 1826 (1980).
4. T. Honore and J. Lauridsen, Acta Chem. Scand., 34B, 235 (1980).
5. M. Begtrup and E. A. Slok, Synthesis, 861 (1993).
6. F. Farina, M. T. Fraile, M. R. Martin, M. U. Martin and A. M. deGuerenu, Heterocycles, 40, 285 (1995).
7. D. Chiarino, M. Napoletano and A. Sala, Synth. Commun., 18, 1171 (1988).
8. D. Chiarino, M. Napoletano and A. Sala, J. Heterocyclic Chem., 24, 43 (1987).
9. K. Bowden, G. Crank and W. J. Ross, J. Chem. Soc. (C), 172 (1968).
10. D. M. Vijas, Y. Chiang and T. W. Doyle, Tetrahedron Letters, 25, 487 (1984).
11. K. Halling, I. Thomsen and K. B. G. Torssell, Liebigs Ann. Chem., 985 (1987).