Inhibition of 11β-hydroxysteroid dehydrogenase obtained from guinea pig kidney by some bioflavonoids and triterpenoids

Acta Pharmacologica Sinica

Volumn 18, Issue 3, 1997, Pages 240-244

  Zhang, Yin Di ^a,c   Wang, Ming Shi ^b  

^a Department of Obstetrics Gynecology   (United States)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

astramembra nin I; emodin; fisetin; hydroxysteroid dehydrogenases; kidney; microsomes; naringenin; oleanolic acid

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ADROGRAPHALIDE; ASTRAMEMBRANIN 1; AURANTIIN; BIOFLAVONOID; CORTISONE; DAPHNETIN; DAPHNIN; EMODIN; FISETIN; GLYCYRRHIZIC ACID; HYDROCORTISONE; NARINGENIN; OLEANOLIC ACID; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY CORTEX; KIDNEY MICROSOME; MALE; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; EMODIN; ENZYME INHIBITORS; FLAVANONES; FLAVONOIDS; GUINEA PIGS; HYDROXYSTEROID DEHYDROGENASES; KIDNEY; MALE; MICROSOMES; OLEANOLIC ACID;

EID: 0030978389     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Funder JW, pearce PT, Myles K, Roy LP. Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action. FASEB 1990; 4: 3234-8.
2. Monder C, White PC. 11 beta-hydroxysteroid dehydrogenase. Vitam Horm 1993; 47: 187-271.
3. Buhler H. Perschel FH, Hierholzer K. Inhibition of rat renal 11β-hydroxysteroid dehydrogenase by steroidal compounds and triterpenoids: structure/function relationship. Biochim Biophys Acta 1991; 1075: 206-12.
4. Sang GW. Lorenzo B, Reidenberg MM. Inhibitory effects of gossypol on corticosteroid 11β-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia. J Steroid Biochem Molec Biol 1991; 39: 169-76.
5. Song D, Lorenzo B, Reidenberg MM. Inhibition of 11β-hydroxysteroid dehydrogenase by gossypol and bioflavonoids. J Lab Clin Med 1992; 120: 792-7.
6. Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11β-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide naringenin and some other compounds. J Steroid Biochem Molec Biol 1994; 49: 81-5.
7. Monder C, Stewart PM, Lakshmi V, Valentine R, Burt D, Edwards CRW. Licorice inhibits corticosteroid 11β-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 1989; 125: 1046-53.
8. Bailey DG, Spence JD, Munoz C, Arnold JMO. Interaction of citrus juice with nifelodipine and nifedipine. Lancet 1991; 337: 268-9.
9. Miniscalco A, Lundahl J, Regardh CG, Edgar B, Eriksson UG. Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther 1992; 261: 1195-9.
10. +-ATPase of rabbit renal medulla and their diuretic action. Acta Pharm Sin 1988; 23: 17-20.
11. Sun Y, Li W, Chen QH. Effect of anthraquinone derivatives on cytochrome P-450 in mice liver microsomes. J Chin Pharm Univ 1988; 19: 110-2.
12. Guo CY, Wang EB. The effect of emodin on arachidonate metabolism in rabbit renal medulla. Chin J Intern Med 1989; 9: 161-3.
13. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of Astragalus (ASI. SK) on experimental liver injury. Acta Pharm Sin 1992; 27: 401-6.
14. Ma XH, Zhao YC, Yin L, Han DW. Study of the effect of oleanolic acid of experimental liver injury. Acta Pharm Sin 1984; 19: 301-5.
15. Buhler H, Kobayashi N, Lichtenstein L, Perschel FH, Siebe H, Hierholzer K. Reversible inhibition of renal 11β-hydroxysteroid dehydrogenase by steroid: structure-function relationship. Kongreß der Gesellschaft für Nephrologie 1992; 21: 374.