Stimulation of hepatocyte glycerolipid synthesis by iron/ADP is due to ADP rather than oxidative stress

Free Radical Biology and Medicine

Volumn 23, Issue 1, 1997, Pages 173-176

  Girón Calle, Julio ^a   Schmid, Harald H O ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

(U 14C glycerol; ADP; Fe3+ ADP; Glycerolipids synthesis; Lipid peroxidation; Rat hepatocytes; TBARS

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GLYCEROLIPID; IRON BINDING PROTEIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; IRON METABOLISM; LIPID OXIDATION; LIPID PEROXIDATION; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ANIMALS; CELLS, CULTURED; FERRIC COMPOUNDS; GLYCEROL; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; OXIDATIVE STRESS; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRIGLYCERIDES;

ANIMALIA;

EID: 0030978379     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00052-X     Document Type: Article

References (27)

1. van den Bosch H. Phosphoglyceride metabolism. Annu. Rev. Biochem. 43:1974;243-277.
2. Holub B., Kuksis A. Metabolism of molecular species of diacylglycerophospholipid. Adv. Lipid Res. 16:1978;1-125.
3. MacDonald J. I. S., Sprecher H. Phospholipid fatty acid remodeling in mammalian cells. Biochim. Biophys. Acta. 1084:1991;105-121.
4. Frankel E. N. Lipid oxidation: Mechanisms, products and biological significance. J. Am. Oil. Chem. Soc. 61:1984;1908-1917.
5. Hochstein P., Nordenbrand K., Ernster L. Evidence for the involvement of iron in the ADP-activated peroxidation of lipids in microsomes and mitochondria. Biochem. Biophys. Res. Commun. 14:1964;323-328.
6. Högberg J., Orrenius S., Larson E. Lipid peroxidation in isolated hepatocytes. Eur. J. Biochem. 50:1975;595-602.
7. Högberg J., Orrenius S., O'Brien P. J. Further studies on lipid-peroxide formation in isolated hepatocytes. Eur. J. Biochem. 59:1975;449-455.
8. Högberg J., Moldéus P., Arborgh B., O'Brien P. J., Orrenius S. The consequences of lipid peroxidation in isolated hepatocytes. Eur. J. Biochem. 59:1975;457-462.
9. Davies M. J., Slater T. F. Studies on the metal-ion and lipoxigenase-catalyzed breakdown of hydroperoxides using electron-spin-resonance spectroscopy. Biochem. J. 245:1987;167-173.
10. Halliwell B., Gutteridge J. M. C. Role of free radicals and catalytic ions in human disease: An overview. Methods Enzymol. 186:1990;1-85.
11. Starke P. E., Farber J. L. Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. J. Biol. Chem. 260:1985;10099-10104.
12. Buettner G. R. The pecking order of free radicals and antioxidants: Lipid peroxidation, α -tocopherol, and ascorbate. Arch. Biochem. Biophys. 300:1993;535-543.
13. Schmid P. C., Johnson S., Schmid H. H. O. Remodeling of rat hepatocyte phospholipids by selective acyl turnover. J. Biol. Chem. 266:1991;13690-13697.
14. Moldéus P., Högberg J., Orrenius S. Isolation and use of liver cells. Methods Enzymol. 52:1978;60-71.
15. Folch J., Lees M., Sloane Stanley G. H. A simple method for the isolation and purification of lipids from animal tissue. J. Biol. Chem. 226:1957;497-507.
16. Bartlett G. R. Phosphorus assay in column chromatography. J. Biol. Chem. 234:1959;466-468.
17. Schmid P. C., Deli E., Schmid H. H. O. Generation and remodeling of phospholipid molecular species in rat hepatocytes. Arch. Biochem. Biophys. 319:1995;168-176.
18. Huber T. C., Edwards H. H., Morrison M. The effect of lactoperoxidase-catalyzed iodination on the integrity of mitochondrial membranes. Arch. Biochem. Biophys. 168:1975;463-472.
19. Schmid P. C., Spimrova I., Schmid H. H. O. Incorporation of exogenous fatty acids into molecular species of rat hepatocytes. Arch. Biochem. Biophys. 322:1995;306-312.
20. Krell H., Ermish N., Kasperek S., Pfaff E. On the mechanisms of ATP-induced and succinate-induced redistribution of cations in isolated rat liver cells. Eur. J. Biochem. 131:1983;247-254.
21. Charest R., Blackmore P. F., Exton J. H. Characterization of responses of isolated rat hepatocytes to ATP and ADP. J. Biol. Chem. 260:1985;15789-15794.
22. 2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes. J. Biol. Chem. 262:1987;13483-13490.
23. Harden T. K., Boyer J. L., Nicholas R. A. P-2 purinergic receptors: Subtype-associated signaling responses and structure. Annu. Rev. Pharmacol. Toxicol. 35:1995;541-579.
24. 2+ concentration of the periphery of hepatocytes. Biochem. J. 283:1992;265-272.
25. Ungemach F. R. Pathobiochemical mechanisms of hepatocellular damage following lipid peroxidation. Chem. Phys. Lipids. 45:1987;171-205.
26. 2+ overload and hepatocyte killing following iron-induced lipid peroxidation. Biochem. Biophys. Res. Commun. 208:1995;813-818.
27. Poli G., Dianzani M. U., Cheeseman K. H., Slater T. F., Lang J., Esterbauer H. Separation and characterization of the aldehytic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat microsomal suspensions. Biochem. J. 227:1985;629-638.