Plasma carnitine kinetics during orthotopic liver transplantation

Scandinavian Journal of Gastroenterology

Volumn 32, Issue 4, 1997, Pages 357-362

  Miki, C ^a   Iriyama, K ^b   Gunson, B K ^b   Suzuki, H ^b   Mcmaster, P ^b  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

carnitine; energy metabolism; liver transplantation

Indexed keywords

ACYLCARNITINE; CARNITINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; FEMALE; HUMAN; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL;

EID: 0030978019     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529709007684     Document Type: Article

References (32)

1. Takada Y, Ozawa K, Yamaoka Y, Uemoto S, Tanaka A, Morimoto T, et al. Arterial ketone body ratio and glucose administration as an energy substrate in relation to changes in ketone body concentration after living-related liver transplantation in children. Transplantation 1993;55:1314-9.
2. Nakatani T. Changes in the energy substrates after hepatectomy: preferential utilization of fatty acids and its effect on hepatic regeneration after major hepatectomy. Arch Jpn Chir 1982; 51:365-81.
3. Simek J, Sedelacek J. Effect of glucose administered in vivo or in vitro on the respiratory quotient of rat liver tissue after partial hepatectomy. Nature 1965;207:761-2.
4. Nakatani T, Ozawa K, Asano M, Ukikusa M, Kamiyama Y, Tobe T. Changes in predominant energy substrate after hepatectomy. Life Sci 1981;28:257-64.
5. Asonuma K, Takaya S, Selby R, Okamoto R, Yamamoto Y, Yokoyama T, et al. The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation. Transplantation 1991;51:164-8.
6. Ozaki N, Ringe B, Gubernatis G, Takada Y, Yamaguchi T, Yamaoka Y, et al. Changes in energy substrates in relation to arterial ketone body ratio after human orthotopic liver transplantation. Surgery 1993;113:403-9.
7. Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL. Cyclosporine and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem 1993;268:13791-8.
8. Blaha V, Simek J, Zadak Z. Liver regeneration in partially hepatectomized rats infused with carnitine and lipids. Exp Toxic Pathol 1992;44:165-8.
9. Adam R, Reynes M, Bao YM, Astarcioglu I, Azoulay D, Chiche L, et al. Impact of glycogen content of the donor liver in clinical liver transplantation. Trans Proc 1993;25:1536-7.
10. Cederblad G, Lindstedt S. A method for the determination of carnitine in the picomole range. Clin Chim Acta 1972;37:235-43.
11. Tsubouchi H, Kawakami S, Hirono S, Miyazaki H, Kimoto M, Arima T, et al. Prediction of outcome in fulminant hepatic failure by serum hepatocyte growth factor. Lancet 1992;340: 307.
12. Rebouche CJ, Engel AG. Tissue distribution of carnitine biosynthetic enzymes in man. Biochim Biophys Acta 1980;630: 22-9.
13. Bohmer T. Conversion of butylbetaine to carnitine in the rat in vivo. Biochim Biophys Acta 1974;343:551-7.
14. Cederblad G, Holm J, Lindstedt G, Lindstedt S, Nordin I, Schersten T. Gamma-butyrobetaine hydroxylase activity in human and ovine liver and skeletal muscle tissue. FEBS Lett 1979;98:57-60.
15. Rebouche CE, Engel AG. Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. J Clin Invest 1984;73:857-67.
16. Brooks DE, McIntosh JEA. Turnover of carnitine by rat tissue. Biochem J 1975;148:439-45.
17. Bohles JH, Akcetin Z. Ketogenic effects of low and high levels of carnitine during total parenteral nutrition in the rat. Am J Clin Nutr 1987;46:47-51.
18. O'Connor JE, Costell M, Miguez MP, Portoles M, Grisolia S. Effect of L-carnitine on ketone bodies, redox state and free amino acids in the liver of hyperammonemic mice. Biochem Pharmacol 1987;36:3169-73.
19. Nishida N, Sugimoto T, Takeuchi T, Kobayashi Y. Effect of L-carnitine on glycogen synthesis and ATP production in cultured hepatocytes of the newborn rat. J Nutr 1989;119:1705-8.
20. Avolio A, Agnes S, Pelosi G, Sollazzi L, Magalini SC, Gozzo ML, et al. Intraoperative trends of oxygen consumption and blood lactate as predictors of primary dysfunction after liver transplantation. Trans Proc 1991;23:2263-5.
21. Persson H, Karlberg I, Svensson O, Stenqvist O, Lundholm K, Andersson C, et al. Rapid indication of allograft function in liver transplantation. Trans Proc 1987;19:3545-8.
22. Skullman S, Ihse I, Larsson J. Availability of energy substrates during liver regeneration in malnourished rats. Scand J Gastroenterol 1991;26:1152-6.
23. Lai HS, Chen WJ. Alterations of remnant liver carnitine palmitoyltransferase I activity and serum carnitine concentration after partial hepatectomy in rats. J Surg Res 1995;59:754-8.
24. Abrahamsson K, Eriksson BO, Holme E, Jodal U, Lindstedt S, Nordin I. Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. Bio Med Met Biol 1994;52:18-21.
25. Iapichino G, Ronzoni G, Bresolin N, Galmarini D, Bordoni A, Prato P, et al. Valutazione dei livelli plasmatici di carnitina dopo trapianto ortotopico di fegato. Min Chir 1989;44:1099-102.
26. Stanley CA. New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency. Adv Pediatr 1987;34:59-88.
27. Schmidt-Sommerfeld E, Penn D, Kerner J, Bieber LL, Rossi TM, Lebenthal E. Quantitation of urinary carnitine esters in a patient with medium-chain acylcoenzyme dehydrogenase deficiency: effect of metabolic state and L-carnitine therapy. J Pediatr 1989;115:577-82.
28. Sandor A, Cseko J, Kispal G, Alkonyi I. Surplus acylcarnitines in the plasma of starved rats derive from the liver. J Biol Chem 1990;265:22313-6.
29. Meyes PA. Oxidation of fatty acids. In: Murray RK, Branner DK, Meyes PA, Rodwell VW, editors. Harper's biochemistry. 23rd ed. London: Appleton & Lange, 1993:220-31.
30. Yamaguchi T, Shimahara Y, Takada Y, Ino K, Mori K, Kobayashi N, et al. Evaluation of ketogenesis in seriously reduced hepatic mitochondrial redox state. An analysis of survivors and non-survivors in critically ill hepatectomized patients. Scand J Gastroentrol 1992;27:472-8.
31. Cooper CS. The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor. Oncogene 1992;7:3-7.
32. Miki C, Iriyama K, Strain A, Harrison JD, Gunson BK, Sherewell JM, et al. Clinical significance of serum hepatocyte growth factor in orthotopic liver transplantation. Surgery 1996;119:505-10.