Phase I and II studies of toremifene

ONCOLOGY

Volumn 11, Issue 5 SUPPL. 4, 1997, Pages 19-22

  Hamm, John T ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; ESTROGEN RECEPTOR; FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING PROTEIN; TAMOXIFEN; TAMOXIFEN CITRATE; TOREMIFENE;

ADULT; BREAST CANCER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HOT FLUSH; HUMAN; MAJOR CLINICAL STUDY; NAUSEA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; SHORT SURVEY; VOMITING;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; FEMALE; HUMANS; RATS; TOREMIFENE;

EID: 0030977939     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (12)

1. Hamm JT, Tormey DC, Kohler PC, et al: Phase I study of toremifene in patients with advanced cancer. J Clin Oncol 9 2036-2041, 1991.
2. Wiebe VJ, Benz CC, Shemano I, et al: Pharmacokinetics of toremifene and its metabolites in patients with advanced breast cancer Cancer Chemother Pharmacol 25:247-251, 1990.
3. Tominaga T, Abe O, Izuo M, et al: A phase I study of toremifene. Breast Cancer Res Treat 16(suppl):S-27, 1990.
4. Kivinen S, Maenpaa J: Effect of toremifene on clinical chemistry, hematology and hormone levels at different doses in healthy postmenopausal volunteers: Phase I study. J Steroid Biochem 36(3):217-220, 1990.
5. Valavaara R, Pyrhonen S, Heikkinen M, et al: Toremifene, a new antiestrogenic compound, for treatment of advanced breast cancer: Phase II study. Eur J Cancer Clin Oncol 24:785-790, 1988.
6. Valavaara R: Phase II trials of toremifene in advanced breast cancer: A review. Breast Cancer Res Treat 1(suppl):S-31, 1990.
7. Modig H, Borgstrom S, Nilsson I, et al: Phase II clinical study of high-dose toremifene in patients with advanced breast cancer. J Steroid Biochem 36:237-238, 1990.
8. Ebbs SR, Roberts JV, Baum M: Alternative mechanism of action of "anti-oestrogens" in breast cancer. Lancer 2:621, 1987.
9. Pyrhonen S, Valavaara R, Vuorinen J, et al: High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen therapy. Breast Cancer Res Treat 29(3):223-228, 1994.
10. Vogel CL, Shemano I, Schoenfelder J, et al: Multicenterphase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer. J Clin Oncol 11:345-350, 1993.
11. Asishi K, Tominaga T, Abe O, et al: Efficacy and safety of high dose NK 622 (toremifene citrate) in tamoxifen failed patients with breast cancer. Jpn J Cancer Chemo 20(1):91-99, 1993.
12. Perry JD, Berry D, Weiss RB, et al: High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer: A phase II trial of the Cancer and Leukemia Group B Breast Cancer Res Treat 36:35-40, 1995.