The effects of different monoaminergic antidepressants on the analgesia induced by spinal cord adrenal medullary transplants in the formalin test in rats

Anesthesia and Analgesia

Volumn 84, Issue 4, 1997, Pages 816-820

  Ortega Alvaro, Antonio ^a   Gibert Rahola, Juan ^a   Mellado Fernández, Manuel L ^a   Chover, Antonio J ^a   Micó, Juan A ^a,b  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b UNIVERSITY OF CÁDIZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; DESIPRAMINE; FLUVOXAMINE; FORMALDEHYDE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CHROMAFFIN CELL; CONTROLLED STUDY; MONOAMINERGIC SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; SUBARACHNOID SPACE; TRANSPLANTATION;

ADRENAL MEDULLA; AMITRIPTYLINE; ANALGESIA; ANIMALS; ANTIDEPRESSIVE AGENTS; DESIPRAMINE; FLUVOXAMINE; FORMALDEHYDE; MALE; RATS; RATS, WISTAR; SPINAL CORD;

EID: 0030977919     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199704000-00022     Document Type: Article

References (23)

1. Sagen J. Transplantation of cells or tissue into the spinal fluid to alleviate chronic pain symptoms. Drug News Perspect 1994;7:325-33.
2. Winnie AP, Pappas GD, Das Gupta TK, et al. Subarachnoid adrenal medullary transplants for terminal cancer pain. A report of preliminary studies. Anesthesiology 1993;79:644-53.
3. Sagen J, Kemmler JE. Increased levels of Met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants. Brain Res 1989;502:1-10.
4. Sagen J, Kemmler JE, Wang H. Adrenal medullary transplants increase spinal cord cerebrospinal fluid catecholamine levels and reduce pain sensitivity. J Neurochem 1991;56:623-7.
5. Eschalier A, Mestre C, Dubray C, Ardid D. Why are antidepressants effective as pain relief? CNS Drugs 1994;2:261-7.
6. Ortega-Alvaro A, Gibert-Rahola J, Chover AJ, et al. Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space as measured by an experimental model of acute pain. Exp Neurol 1994;130:9-14.
7. Malseed RT, Goldstein FJ. Enhancement of morphine analgesia by tricyclic antidepressants. Neuropharmacology 1979;18:827-9.
8. O'Neill KA, Valentino D. Chronic desipramine attenuates morphine analgesia. Pharmacol Biochem Behav 1986;24:155-8.
9. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10.
10. Hyttel J. Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry 1982;6:277-95.
11. González-Darder JM, Ruz-Franzi JI. Acciön antálgica del trasplante de médula suprarrenal al espacio subaracnoideo lumbar. Estudio experimental. Rev Esp Anestesiol Reanim 1991;38:230-3.
12. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats. Pain 1977;4:161-74.
13. Cooper JR, Blomm FE, Roth RH. Dopamine. In: Cooper JR, Blomm FE, Roth RH, eds. The biochemical basis of neuropharmacology. New York: Oxford University Press, 1991:285-337.
14. Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987;30:103-14.
15. Dennis SG, Melzack R. Comparison of phasic and tonic pain in animals. In: Bonica JJ, Liebeskind JC, Albe-Fessard D, eds. Advances in pain research and therapy. New York: Raven Press, 1979:747-60.
16. Botney M, Fields HL. Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Ann Neurol 1983;13:160-4.
17. Sewell RDE. Supraspinal and spinal monoamine-modified function and the expression of opioid antinociception. J Psychopharmacol 1991;5:352-9.
18. Hamon M, Gozlan H, Bourgoin S, et al. Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology 1987;26:531-9.
19. Valverde O, Micó JA, Maldonado R, et al. Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioral pain tests in mice. Prog Neuropsychopharmacol Biol Psychiatry 1994;18:1073-92.
20. Reisine T, Soubrie P. Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment. Eur J Pharmacol 1982;77:39-44.
21. Somoza E, Galindo A, Bazán E, et al. Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain. Neuropsychobiology 1981;7:297-301.
22. Dougherty DD, Sortwell CE, Sagen J. Pharmacologic specificity of antidepressive activity by monoaminergic neural transplants. Psychopharmacology [Berl] 1995;118:10-8.
23. Tejedor-Real P, Micó JA, Corbalán JP, et al. Attenuation of learned helplessness in rats after transplant of adrenal medulla into the spinal cord. Eur Psychiatry 1996;11:249-53.