Determination of S-1 (combined drug of tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate) and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass spectrometry

Journal of Chromatography B: Biomedical Applications

Volumn 691, Issue 1, 1997, Pages 95-104

  Matsushima, Eiji ^a   Yoshida, Kozo ^a   Kitamura, Ryuichi ^a   Yoshida, Ken Ichiro ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

5 Chloro 2,4 dihydroxypyridine; 5 Fluorouracil; Potassium oxonate; S 1; Tegafur

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; ANTINEOPLASTIC AGENT; FLUOROURACIL; OXONIC ACID; TEGAFUR;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MASS SPECTROMETRY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPRODUCIBILITY; TECHNIQUE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMBINATIONS; DRUG STABILITY; FLUOROURACIL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; OXONIC ACID; PYRIDINES; SENSITIVITY AND SPECIFICITY; TEGAFUR;

EID: 0030976586     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00429-X     Document Type: Article

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