Stability of the principal cytostatic agents during storage at unusual temperatures

International Journal of Pharmaceutics

Volumn 149, Issue 1, 1997, Pages 37-42

  Martel, P ^a,b   Pinguet, F ^a   Petit, I ^a   Poujol, S ^a   Astre, C ^a   Fabbro, M ^a  

^a CENTRE VAL D AURELLE   (France)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

Author keywords

Antineoplastic agents; High performance liquid chromatography; Stability; Storage; Temperature

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; IFOSFAMIDE; MELPHALAN; METHOTREXATE;

ARTICLE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; STORAGE; TEMPERATURE;

EID: 0030976076     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04851-X     Document Type: Article

References (18)

1. Barberi-Heyob, M., Merlin, J.L. and Weber, B., Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography. J. Chromatogr., 573 (1992) 247-252.
2. Bienvenuto, J.A., Anderson, R.W., Kerkof, K., Smith, R.G. and Loo, T.L., Stability and compatibility of antitumor agents in glass and plastic containers. Am. J. Hosp. Pharm., 38 (1981) 1914-1918.
3. Boehringer Mannheim Laboratories, Determination of urea package insert. Meylan, France, 1995.
4. Brooke, D., Scott, J.A. and Bequette, R.J., Effect of briefly heating cyclophosphamide solutions. Am. J. Hosp. Pharm., 32 (1975) 44-45.
5. Chang, S.Y., Alberts, D.S., Farquhar, D.S., Melnick, L.R., Walson, P.D. and Salmon, S.E., Hydrolysis and protein binding of melphalan. J. Pharm. Sci., 67 (1978) 526-531.
6. Cheung, H.W., Cradock, J.C., Vishnuvajjala, B.R. and Flora, K.P., Stability of cisplatine, iproplatin, carboplatin, and tetraplatin in commonly used intravenous solutions. Am. J. Hosp. Pharm., 41 (1987) 124-130.
7. Dyvik, O., Grislingass, A.L., Hjorth Tonnesen, H. and Karlsen, J., Methotrexate in infusion solutions. A stability test for the hospital pharmacy. J. Clin. Hosp. Pharm., 11 (1986) 343-348.
8. Jardine, I., Strife, R.J. and Colvin, M., Analysis of VP 16-213 and VM 26 in plasma by high-performance liquid chromatography with UV and or fluorescence detection. Cancer Chemother. Pharmacol., 7 (1982) 237.
9. Oliary, J., Deux techniques simples et rapides de dosage plasmatique d'anticancéreux par CLHP: doxorubicine-épidoxorubicine, mitoxantrone. Opito-Laboratoire Lederle, 1989, pp. 5.
10. Pinguet, F., Fabre, G., Canal, P., Pujol, A. and Soula, G., Stabilité des solutions de 5-fluorouracile à la chaleur et à la lumière. J. Pharm. Clin., 9 (1990) 155-158.
11. Pinguet, F., Martel, P., Rouanet, P., Fabbro, M. and Astre, C., Effect of sodium chloride concentration and temperature on melphalan stability during storage and use. Am. J. Hosp. Pharm., 51 (1994) 2701-2704.
12. Rochard, E., Barthes, D. and Courtois, P., Stability of fluorouracil, cytarabine, or doxorubicin hydrochloride in ethylene vinylacetate portable infusion-pump reservoirs. Am. J. Hosp. Pharm., 49 (1992) 619-623.
13. Roche Laboratories, 5-Fluorouracil package insert. Neuilly/Seine, France, 1994.
14. Trissel, L.A., Handbook on Injectable Drugs, 5th Edn, American Society of Hospital Pharmacist, Washington, 1988.
15. Wellcome Laboratories, Melphalan package insert, Issy les Moulineaux, France, 1992.
16. Williams, D.A. and Lokich, J., A review of the stability and compatibility of antineoplastic drugs for multiple-drug infusions. Cancer Chemother. Pharmacol., 31 (1992) 171-181.
17. Williams, D.A., Stability and compatibility of admixtures of antineoplasic drugs. In Lokich, J. (Ed.), Cancer Chemotherapy by infusion, 2nd Edn, Precept, Chicago, 1990.
18. Zheng, J.J., Chan, K.K. and Muggia, F., Preclinical pharmacokinetics and stability of isophosphoramide mustard. Cancer Chemother, Pharmacol., 33 (1994) 391-398.