Unexpected lability of cysteine acetamidomethyl thiol protecting group: Tyrosine ring alkylation and disulfide bond formation upon acidolysis

Journal of Peptide Research

Volumn 49, Issue 4, 1997, Pages 341-346

  Engebretsen, May ^a   Agner, Erik ^a   Sandosham, Jessie ^a   Fischer, Peter M ^a  

^a ALTANA PHARMA AG   (Germany)

Author keywords

Acetamidomethyl (Acm); Acidolysis; Cyclisation; Ellman's reagent; Peptide oxidation; Protecting group; Side reaction; Tyr alkylation

Indexed keywords

PEPTIDE; RESIN;

ALKYLATION; ARTICLE; CYCLIZATION; DISULFIDE BOND; MOLECULAR STABILITY; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY;

EID: 0030975881     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.1997.tb01135.x     Document Type: Article

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