Realistic simulation of the Aplysia siphon-withdrawal reflex circuit: Roles of circuit elements in producing motor output

Journal of Neurophysiology

Volumn 77, Issue 3, 1997, Pages 1249-1268

  Lieb Jr , J R ^a   Frost, W N ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APLYSIA; ARTICLE; COMPUTER SIMULATION; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SYNAPSE; WITHDRAWAL REFLEX;

EID: 0030975746     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.3.1249     Document Type: Article

References (54)

1. BLAZIS, D.E.J., FISCHER, T. M., AND CAREW, T. J. A neural network model of inhibitory information processing in Aplysia. Neural Comput. 5: 213-227, 1993.
2. BRODFUEHRER, P. D. AND FRIESEN, W. O. Initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. II. Role of segmental swim-initiating interneurons. J. Comp. Physiol. A Sens. Neural Behav. Physiol. 159: 503-510, 1986.
3. BYRNE, J. H. Analysis of synaptic depression contributing to habituation of gill withdrawal reflex in Aplysia californica. J. Neurophysiol. 48: 431-438, 1982.
4. BYRNE, J. H., CASTELLUCCI, V. F., CAREW, T. J., AND KANDEL, E. R. Stimulus-response relations and stability of mechanoreceptor and motor neurons mediating defensive gill-withdrawal reflex in Aplysia. J. Neurophysiol. 41: 402-417, 1978a.
5. BYRNE, J. H., CASTELLUCCI, V. F., AND KANDEL, E. R. Receptive fields and response properties of mechanoreceptor neurons innervating siphon skin and mantle shelf in Aplysia. J. Neurophysiol. 37: 1041-1064, 1974.
6. BYRNE, J. H., CASTELLUCCI, V. F., AND KANDEL, E. R. Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia. J. Neurophysiol. 41: 418-431, 1978b.
7. BYRNE, J. H. AND KANDEL, E. R. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16: 425-435, 1996.
8. CASTELLUCCI, V. AND KANDEL, E. R. Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia. Science Wash. DC 194: 1176-1178, 1976.
9. CASTELLUCCI, V., PINSKER, H., KUPFERMANN, I., AND KANDEL, E. R. Neuronal mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science Wash. DC 167: 1745-1748, 1970.
10. CLEARY, L. J. AND BYRNE, J. H. Identification and characterization of a multifunction neuron contributing to defensive arousal in Aplysia. J. Neurophysiol. 70: 1767-1776, 1993.
11. CLEARY, L. J., BYRNE, J. H., AND FROST, W. N. Role of interneurons in defensive withdrawal reflexes in Aplysia. Learn. Memory 2: 133-151, 1995.
12. COHEN, T. E., HENZI, V., KANDEL, E. R., AND HAWKKINS, R. D. Further behavioral and cellular studies of dishabituation and sensitization in Aplysia. Soc. Neurosci. Abstr. 17: 1302, 1991.
13. DEADWYLER, S. A., HAMPSON, R. E., FOSTER, T. E., AND MARLOW, G. The functional significance of long-term potentiation: relation to sensory processing by hippocampal circuits. In: Long-Term Potentiation: From Biophysics to Behavior, edited by P. W. Landfield and S. A. Deadwyler. New York: Liss, 1988, p. 499-534.
14. DOWLING, J. E. Neurons and Networks. Cambridge, MA: Harvard Univ. Press, 1992.
15. DUBUC, B. AND CASTELLUCCI, V. Receptive fields and properties of a new cluster of mechanoreceptor neurons innervating the mantle region and the branchial cavity of the marine mollusk Aplysia californica. J. Exp. Biol. 156: 315-334, 1991.
16. ECCLES, J. C. The Physiology of Synapses. Berlin: Springer-Verlag, 1964.
17. FISCHER, T. M. AND CAREW, T. J. Activity-dependent potentiation of recurrent inhibition: a mechanism for dynamic gain control in the siphonwithdrawal reflex of Aplysia. J. Neurosci. 13: 1302-1314, 1993.
18. FISCHER, T. M. AND CAREW, T. J. Cutaneous activation of the inhibitory L30 interneurons provides a mechanism for regulating adaptive gain control in the siphon-withdrawal reflex of Aplysia. J. Neurosci. 15: 762-773, 1995.
19. FISHER, S. A., FISCHER, T. M., AND CAREW, T. J. A computational model of activity-dependent potentiation and its external modulation at L30 inhibitory synapses in Aplysia. Soc. Neurosci. Abstr. 21: 1457, 1995.
20. FROST, W. N. Mechanisms Contributing to Short- and Long-Term Sensitization in Aplysia (PhD dissertation). New York: Columbia Univ., 1987.
21. FROST, W. N., CLARK, G. A., AND KANDEL, E. R. Parallel processing of short-term memory for sensitization in Aplysia. J. Neurobiol. 19: 297-334, 1988.
22. FROST, W. N. AND KANDEL, E. R. Structure of the network mediating siphon-elicited siphon-withdrawal in Aplysia. J. Neurophysiol. 73: 2413-2427, 1995.
23. FROST, W. N., WU, L. G., AND LIEB, J. Simulation of the Aplysia siphonwithdrawal reflex circuit: slow components of interneuronal synapses contribute to the mediation of reflex duration. Soc. Neurosci. Abstr. 17: 1390, 1991.
24. GETTING, P. A. Mechanisms of pattern generation underlying swimming in Tritonia. II. Network reconstruction. J. Neurophysiol. 49: 1017-1035, 1983.
25. GETTING, P. A. Reconstruction of small neural networks. In: Methods in Neuronal Modeling: From Synapses to Networks, edited by C. Koch and I. Segev. Cambridge, MA: MIT Press, 1989a.
26. GETTING, P. A. Emerging principles governing the operation of neural networks. Annu. Rev. Neurosci. 12: 185-204, 1989b.
27. GILLETTE, R., KOVAC, M. P., AND DAVIS, W. J. Command neurons in Pleurobranchaea receive synaptic feedback from the motor network they excite. Science Wash. DC 199: 798-801, 1978.
28. HAWKINS, R. D., CASTELLUCCI, V. F., AND KANDEL, E. R. Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. I. Identification and characterization. J. Neurophysiol. 45: 304-314, 1981.
29. HAWKINS, R. D., KANDEL, E. R., AND SIEGELBAUM, S. A. Learning to modulate transmitter release: themes and variations in synaptic plasticity. Annu. Rev. Neurosci. 16: 625-665, 1993.
30. HAWKINS, R. D. AND SCHACHER, S. Identified facilitator neurons L29 and L28 are excited by cutaneous stimuli used in dishabituation, sensitization, and classical conditioning of Aplysia. J. Neurosci. 9: 4236-4245, 1989.
31. HICKIE, C. Functional and Motor Neuronal Analysis of Defensive Siphon Responses in Aplysia californica (PhD dissertation). Houston, TX: Univ. of Texas at Houston Health Science Center, 1994.
32. HICKIE, C. AND WALTERS, E. T. Motor neuronal control of tail-directed and head-directed siphon responses in Aplysia californica. J. Neurophysiol. 74: 307-321, 1995.
33. HULTBORN, H., LINDSTROM, S., AND WIGSTROM, H. On the function of recurrent inhibition in the spinal cord. Exp. Brain Res. 37: 399-403, 1979.
34. KANDEL, E. R. AND SCHWARTZ, J. H. Molecular biology of learning: modulation of transmitter release. Science Wash. DC 218: 433-443, 1982.
35. KANDEL, E. R., SCHWARTZ, J. H., AND JESSEL, T., M. Principles of Neural Science. New York: Elsevier, 1991.
36. KAPLAN, S. W., KANDEL, E. R., AND HAWKINS, R. D. Plasticity in the monosynaptic component of the Aplysia gill-withdrawal reflex during habituation, dishabituation, and sensitization. Soc. Neurosci. Abstr. 19: 16, 1993.
37. KOCH, C. AND BOWER, J. M. Experimentalists and modelers: can we all just get along? Trends Neurosci. 15: 458-461, 1992.
38. LIEB, J. R., JR. AND FROST, W. N. Interneuronal plasticity contributes significantly to enhanced motor neuron firing during sensitization of the Aplysia siphon-withdrawal reflex. Soc. Neurosci. Abstr. 18: 531, 1992.
39. LIEB, J. R., JR. AND FROST, W. N. Dynamic representation of learned information in a distributed memory in Aplysia. Soc. Neurosci. Abstr. 21: 1458, 1995.
40. LORENTE DE NO, R. Analysis of the activity of the chains of internuncial neurons. J. Neurophysiol. 1: 207-244, 1938.
41. PERKEL, D. H., MULLONEY, B., AND BUDELLI, R. W. Quantitative methods for predicting neuronal behavior. Neuroscience 6: 823-837, 1981.
42. POMPEIANO, O. Recurrent inhibition. In: Handbook of the Spinal Cord, edited by R. A. Davidoff. New York: Dekker, 1984.
43. RENSHAW, B. Influence of the discharge of motoneurons upon excitation of neighboring motoneurons. J. Neurophysiol. 4: 167-183, 1941.
44. ROBERTS, A., DALE, N., AND SOFFE, S. R. Sustained responses to brief stimuli: swimming in Xenopus embryos. J. Exp. Biol. 112: 321-335, 1984.
45. SEGEV, I. Single neurone models: oversimple, complex, and reduced. Trends Neurosci. 15: 414-421, 1992.
46. SHOEMAKER, M. AND HANNAFORD, B. A study and model of the role of the Renshaw cell in regulating the transient firing rate of the motoneuron. Biol. Cybern. 71: 251-262, 1994.
47. STRINGER, J. L. AND LOTHMAN, E. W. Reverberatory seizure discharges in hippocampal-parahippocampal circuits. Exp. Neurol. 116: 198-203, 1992.
48. TRUDEAU, L. E. AND CASTELLUCCI, V. F. Contribution of polysynaptic pathways in the mediation and plasticity of Aplysia gill and siphon-withdrawal reflex: evidence for differential modulation. J. Neurosci. 12: 3838-3848, 1992.
49. TRUDEAU, L. E. AND CASTELLUCCI, V. F. Functional uncoupling of inhibitory interneurons plays an important role in short-term sensitization of the Aplysia gill and siphon-withdrawal reflex. J. Neurosci. 13: 2126-2135, 1993a.
50. TRUDEAU, L. E. AND CASTELLUCCI, V. F. Sensitization of the gill and siphon-withdrawal reflex of Aplysia: multiple sites of change in the neuronal network. J. Neurophysiol. 70: 1210-1220, 1993b.
51. TSAU, Y., WU, J., HOPP, H., COHEN, L. B., SCHIMINOVICH, D., AND FALK, C. X. Distributed aspects of the response to siphon touch in Aplysia: spread of stimulus information and cross-correlation analysis. J. Neurosci. 14: 4167-4184, 1994.
52. WHITE, J. A., ZIV, I., CLEARY, L. J., BAXTER, D. A., AND BYRNE, J. H. The role of interneurons in controlling the tail-withdrawal reflex in Aplysia: a network model. J. Neurophysiol. 70: 1777-1786, 1993.
53. WRIGHT, W. G. AND CAREW, T. J. A single identified interneuron gates tail-shock induced inhibition in the siphon-withdrawal reflex of Aplysia. J. Neurosci. 15: 790-797, 1995.
54. WRIGHT, W. G., MARCUS E. A., AND CAREW, T. J. A cellular analysis of inhibition in the siphon-withdrawal reflex of Aplysia. J. Neurosci. 11: 2498-2509, 1991.