Daleformis, a new phytoalexin from the roots of Dalea filiciformis: An inhibitor of endothelin converting enzyme

Journal of Natural Products

Volumn 60, Issue 3, 1997, Pages 306-308

  Patil, Ashok D ^a   Freyer, Alan J ^a   Eggleston, Drake S ^a   Haltiwanger, R Curtis ^a   Tomcowicz, Brian ^a   Breen, Ann ^a   Johnson, Randall K ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DALEFORMIS; ENDOTHELIN 1; ENDOTHELIN CONVERTING ENZYME; ENZYME INHIBITOR; PHYTOALEXIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG STRUCTURE; HYPERTENSION; KIDNEY FAILURE; NONHUMAN; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; VASOCONSTRICTION; X RAY CRYSTALLOGRAPHY;

ACETYLATION; ASPARTIC ENDOPEPTIDASES; BENZOFURANS; BENZOPYRANS; CHROMATOGRAPHY, THIN LAYER; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; METALLOENDOPEPTIDASES; MOLECULAR CONFORMATION; PLANT ROOTS; PLANTS, MEDICINAL; SPECTROPHOTOMETRY, INFRARED;

DALEA FILICIFORMIS;

EID: 0030975485     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np960654e     Document Type: Article

References (9)

1. Lyne, R.; Mulheirn, L.; Leworthy, D. J. Chem. Soc. Chem. Comm. 1976, 19, 498.
2. Patil, A. D.; Freyer, A. J.; Breen, A.; Carte, B.; Johnson, R. K. J. Nat. Prod. 1996, 59, 606-608.
3. CAD-4 Operations Manual; Enraf-Nonius: Delft, The Netherlands, 1977.
4. Sheldrick, G. M. Acta Cryst. 1990, A46, 467-473.
5. Sheldrick, G. M. SHELX93. Program for the Refinement of Crystal Structures, University of Gottingen: Gottingen, Germany, 1993.
6. International Tables for Crystallography, Wilson, A. J. C., Ed.; Kluwer Academic: Dordrecht, 1992; Vol. C.
7. Flack, H. D. Acta Cryst. 1983, A39, 876-881.
8. Flack, H. D.; Schwarzenbach, D. Acta Cryst. 1988, A44, 499-506.
9. The author has deposited atomic coordinates for 2 with the Cambridge Crystallographic Data Centre. The coordinates can be obained, upon request, from Dr. Olga Kennard, University Chemical Laboratory, 12 Union Road, Cambridge CB2 1EZ, U.K.