A pulmonary influenza virus infection in SCID mice can be cured by treatment with hemagglutinin-specific antibodies that display very low virus- neutralizing activity in vitro

Journal of Virology

Volumn 71, Issue 6, 1997, Pages 4347-4355

  Mozdzanowska, Krystyna ^a   Furchner, Michelle ^a   Washko, George ^a   Mozdzanowski, Jacek ^a   Gerhard, Walter ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; COBROTOXIN; GANGLIOTETRAOSYLCERAMIDE; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS HEMAGGLUTININ;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEMAGGLUTINATION INHIBITION; HOST CELL; INFLUENZA VIRUS; INHALATIONAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG INFECTION; MALE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; VIRION; VIRUS EXCRETION; VIRUS NEUTRALIZATION;

EID: 0030975069     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.6.4347-4355.1997     Document Type: Article

References (45)

1. Becht, H., R. T. C. Huang, B. Fleischer, C. B. Boschek, and R. Rott. 1984. Immunogenic properties of the small chain HA2 of the hemagglutinin of influenza viruses. J. Gen. Virol. 65:173-183.
2. Beebe, D. P., R. D. Schreiber, and N. R. Cooper. 1983. Neutralization of influenza virus by normal human sera: mechanisms involving antibody and complement. J. Immunol. 130:1317-1322.
3. Benne, C. A., C. A. Kraaijeveld, J. A. G. van Strijp, E. Brouwer, M. Harmsen, J. Verhoef, L. M. G. van Golde, and J. F. van Iwaarden. 1995. Interactions of surfactant protein A with influenza A viruses: binding and neutralization. J. Infect. Dis. 171:335-341.
4. Blusse Van Oud Albas, A., and R. Van Furth. 1979. Origine, kinetics, and characteristics of pulmonary macrophages in the normal steady state. J. Exp. Med. 149:1504-1518.
5. Boere, W. A. M., B. J. Benaissa-Trouw, T. Harmsen, T. Erich, C. A. Kraaijeveld, and H. Snippe. 1985. Mechanism of monoclonal antibody-mediated protection against virulent semliki forest virus. J. Virol. 54:546-551.
6. Brandriss, M. W., J. J. Schlesinger, E. E. Walsh, and M. Briselli. 1986. Lethal 17D yellow fever encephalitis in mice. I. Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses. J. Gen. Virol. 67:229-234.
7. Buchmeier, M. J., R. M. Welsh, F. J. Dutko, and M. B. A. Oldstone. 1980. The virology and immunopathology of lymphocytic choriomeningitis virus infection. Adv. Immunol. 30:275-326.
8. Burns, J. W., M. Siadat-Pajouh, A. A. Krishnaney, and H. B. Greenberg. 1996. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 272:104-107.
9. Caton, A. J., G. G. Brownlee, J. W. Yewdell, and W. Gerhard. 1982. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 31:417-427.
10. Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature (London) 312:548-551.
11. Crowe, J. E., B. R. Murphy, R. M. Chanock, R. A. Williamson, C. F. Barbas, and D. R. Burton. 1994. Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice. Proc. Natl. Acad. Sci. USA 91:1386-1390.
12. Dietzschold, B., M. Kao, Y. M. Zheng, Z. Y. Chen, G. G. Maul, Z. F. Fu, C. E. Rupprecht, and H. Koprowski. 1992. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc. Natl. Acad. Sci. USA 89:7252-7256.
13. Dimmock, N. J. Neutralization of animal viruses. Springer-Verlag, New York, N.Y.
14. Doherty, P. C., T. J. Topham, and R. A. Tripp. 1996. Analysing the T cell response to influenza virus in mouse model systems, p. 153-165. In L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Options in the control of influenza III. Elsevier Science Publishing, Inc., New York, N.Y.
15. Fujinami, R. S., E. Norrby, and M. B. A. Oldstone. 1984. Antigenic modulation induced by monoclonal antibodies: antibodies to measles virus hemagglutinin alters expression of other viral polypeptides in infected cells. J. Immunol. 132:2618-2621.
16. Fujisawa, H., S. Tsuru, M. Taniguchi, Y. Zinnaka, and K. Nomoto. 1987 Protective mechanisms against pulmonary infection with influenza virus. I. Relative contribution of polymorphonuclear leukocytes and of alveolar macrophages to protection during the early phase of intranasal infection. J. Gen. Virol. 68:425-432.
17. Gerhard, W., J. Yewdell, M. E. Frankel, and R. Webster. 1981. Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies. Nature (London) 290:713-717.
18. Graham, M. B., and T. J. Braciale. 1996. Influenza virus clearance in B lymphocyte deficient mice, p. 166-169. In L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Options in the control of influenza III. Elsevier Science Publishing, Inc., New York, N.Y.
19. Hartley, A. A., D. C. Jackson, and E. M. Anders. 1992. Two distinct serum mannose-binding lectins function as β inhibitors of influenza virus: identification of bovine serum β inhibitor as conglutinin. J. Virol. 66:4358-4363.
20. Hartshorn, K. L., K. Sastry, D. Brown, M. R. White, T. B. Okarma, Y.-M. Lee, and A. I. Tauber. 1993. Conglutinin acts as an opsonin for influenza A viruses. J. Immunol. 151:6265-6273.
21. Hicks, J. T., F. A. Ennis, E. Kim, and M. Verbonitz. 1978. The importance of an intact complement pathway in recovery from a primary viral infection: influenza in decomplemented and in C5-deficient mice. J. Immunol. 121: 1437-1445.
22. Hunt, A. R., W. A. Short, A. J. Johnson, R. A. Bolin, and J. T. Roehrig. 1991. Synthetic peptides of the E2 glycoprotein of Venezuelan equine encephalitis virus. II. Antibody to the amino terminus protects animals by limiting viral replication. Virology 185:281-290.
23. Kavaler, J., A. J. Caton, L. M. Staudt, D. Schwartz, and W. Gerhard. 1990. A set of closely related antibodies dominates the primary antibody response to the antigenic site Cb of the A/PR/8/34 influenza virus hemagglutinin. J. Immunol. 145:2312-2321.
24. Kida, H., L. E. Brown, and R. G. Webster. 1982. Biological activity of monoclonal antibodies to operationally defined antigenic regions on the hemagglutinin molecule of A/Seal/Massachusetts/1/80 (H7N7) influenza virus. Virology 122:38-47.
25. Lefrancois, L. 1984. Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo. J. Virol. 51:208-214.
26. Levine, B., J. M. Hardwick, B. D. Trapp, T. O. Crawford, R. C. Bolliger, and D. E. Griffin. 1991. Antibody-mediated clearance of alphvirus infection from neurons. Science 254:856-859.
27. Liebert, U. G., S. Schneider-Schaulies, K. Baczko, and V. TerMeulen. 1990. Antibody-induced restriction of viral gene expression in measles encephalitis in rats. J. Virol. 64:706-713.
28. Mathews, J. H., J. T. Roehrig, and D. W. Trent. 1985. Role of complement and the Fc portion of immunoglobulin G in immunity to Venezuelan equine encephalomyelitis virus infection with glycoprotein-specific monoclonal antibodies. J. Virol. 55:594-600.
29. McCullough, K. C. 1986. Monoclonal antibodies: implications for virology. Arch. Virol. 87:1-36.
30. Moskophidis, D., J. Lohler, and F. Lehmann-Grube. 1987. Antiviral antibody-producing cells in parenchymatous organs during persistent virus infection. J. Exp. Med. 165:705-719.
31. Palladino, G., K. Mozdzanowska, G. Washko, and W. Gerhard. 1995. Virus-neutralizing antibodies of immunoglohulin G (IgG) hut not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J. Virol. 69:2075-2081.
32. Pincus, S. H., R. Cole, R. Ireland, F. McAtee, R. Fujisawa, and J. Portis. 1995. Protective efficacy of nonneutralizing monoclonal antibodies in acute infection with murine leukemia virus. J. Virol. 69:7152-7158.
33. Prince, G. A., V. G. Hemmig, R. L. Horswood, P. A. Baron, and R. M. Chanock. 1987. Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J. Virol. 61:1851-1854.
34. Rector, J. T., R. N. Lausch, and J. E. Oakes. 1982. Use of monoclonal antibodies for analysis of antibody-dependent immunity to ocular herpes simplex virus type 1 infection. Infect. Immun. 38:168-174.
35. Scherle, P. A., G. Palladino, and W. Gerhard. 1992. Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells. J. Immunol. 148:212-217.
36. 2 fragments of protective monoclonal antibodies to yellow fever virus (YF) envelope protein fail to protect mice against lethal YF encephalitis. J. Gen. Virol. 76: 217-220.
37. Schmaljohn, A. L., E. D. Johnson, J. M. Dalrymple, and G. A. Cole. 1982. Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis. Nature (London) 297:70-72.
38. Staudt, L. M., and W. Gerhard. 1983. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. J. Exp. Med. 157:687-704.
39. Stein-Streilein, J., M. Bennett, D. Mann, and V. Kumar. 1983. Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection. J. Immunol. 131:2699-2704.
40. Stein-Streilein, J., and J. Guffee. 1986. In vivo treatment of mice and hamsters with antibodies to asialo-GM1 increases morbidity and mortality to pulmonary influenza infection. J. Immunol. 136:1435-1441.
41. Taylor, G., E. J. Stott, M. Bew, B. F. Fernie, P. J. Cote, A. P. Collins, M. Hughes, and J. Jebbett. 1984. Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 52:137-142.
42. Virgin, H. W., R. Bassel-Duby, B. N. Fields, and K. L. Tyler. 1988. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J. Virol. 62:4594-4604.
43. Wiley, D. C., and J. J. Skehel. 1987. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56:366-394.
44. Wilson, I. A., and N. J. Cox. 1990. Structural basis of immune recognition of influenza virus hemagglutinin. Annu. Rev. Immunol. 8:737-771.
45. -) variants obtained by mutagenesis of mouse mastocytoma P815. Immunogenetics 26:178-187.