Single and coencapsulation of interferon-γ in biodegradable PLA microspheres for optimization of multicomponent vaccine delivery vehicles

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 4, Issue 2, 1997, Pages 75-80

  Conway, B R ^a   Alpar, H O ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Biodegradable polymers; Drug delivery; Interferon ; Microspheres; Vaccines

Indexed keywords

BOVINE SERUM ALBUMIN; CYTOKINE; DICHLOROMETHANE; HUMAN SERUM ALBUMIN; IODINE 125; METHYLCELLULOSE; MICROSPHERE; POLYLACTIDE; POLYVINYL ALCOHOL; PROTEIN; RECOMBINANT GAMMA INTERFERON; SOLVENT; VACCINE;

ARTICLE; BIODEGRADATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; ENCAPSULATION; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

EID: 0030974433     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549709051876     Document Type: Article

References (19)

1. Almeida, A. J., Alpar, H. O., and Brown, M. R. W. (1993) Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly (L-lactic acid) microspheres in rats, rabbits and guinea-pigs. J. Pharm. Pharmacol. 45, 198-203.
2. Cleland, J. L., and Yang, J. (1995) In vitro release of bioactive recombinant human interferon-γ from PLGA microspheres. Proceedings of the International Symposium on Controlled Release of Bioactive Materials 22, 518-519.
3. Conway, B. R., and Alpar, H. O. (1996a) Co-encapsulation of proteins into PLA microspheres. Pharm. Sci. 2, 173-176.
4. Conway, B. R., and Alpar, H. O. (1996b) Double emulsion microencapsulation of proteins as model antigens using polylactide polymers: Effect of emulsifier on the microsphere characteristics and release kinetics. Eur. J. Pharm. Biopharm. 42, 42-48.
5. Conway, B. R., Alpar, H. O., and Lewis, D. A. (1994) Studies on the optimisation of loading and release kinetics of interferon-gamma from polyactide microspheres. Proceedings of the International Symposium on Controlled Release of Bioactive Materials 21, 284-285.
6. Couvreur, P., Dubernet, C., and Puisieux, F. (1995) Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur. J. Pharm. Biopharm. 41, 2-13.
7. Fujioka, K., Takada, Y., Sato, S., and Miyata, T. (1995) Long-acting delivery system of interferon: IFN minipellet. J. Controlled Release 33, 317-323.
8. Heya, T., Okada, H., Tanigawara, Y., Ogawa, Y., and Toguchi, H. (1991) Effects of counterion of TRH and loading amount on control of TRH release from copoly(D,L-lactic/glycolic acid) microspheres prepared by an in-water drying method. Int. J. Pharm. 69, 69-75.
9. Hora, M. S., Rana, R. K., Nunberg, J. H., Tice, T. R., Gilley, R. M., and Hudson, M. E. (1990a) Controlled release of interleukin-2 from biodegradable microspheres. Biotechnology 8, 755-758.
10. Hora, M. S., Rana, R. K., Nunberg, J. H., Tice, T. R., Gilley, R. M., and Hudson, M. E. (1990b) Release of human serum albumin from poly(lactide-co-glycolide) microspheres. Pharm. Res. 7, 1190-1194.
11. Hunter, J. R., Carbonell, R. G., and Kilpatrick, P. K. (1991) Coadsorption and exchange of lysozyme/β-casein mixtures at the air/water interface. J. Colloid Interface Sci. 143, 37-53.
12. Jani, P., Halbert, G. W., Langridge, J., and Florence, A. T. (1990) Nanoparticle uptake by the rat gastro-intestinal mucosa: Quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821-826.
13. Maysinger, D., Filipovic-Grcic, J., and Cuello, A. C. (1993) Effects of coencapsulated NGF and GM1 in rats with cortical lesions. Neuroreport 4, 971-974.
14. Peters, T. (1975) Serum albumin. In The Plasma Proteins: Structure, Function and Genetic Control, ed. F. W. Putnam, 133-181. New York: Academic Press.
15. Playfair, J. H. L., and DeSouza, J. B. (1987) Recombinant gamma-interferon is a potent adjuvant for a malaria vaccine in mice. Clin. Exp. Immunol. 67, 5-10.
16. Schugens, C., Laruelle, N., Nihant, N., Grandfils, C., Jerome, R., and Teyssie, P. (1994) Effect of the emulsion stability on the morphology and porosity of semi-crystalline poly L-lactide microparticles prepared by w/o/w double emulsion-evaporation. J. Controlled Release 32, 161-176.
17. Smith, P. K., Krohn, R. I., Hermanson, G. T., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
18. Suttiprasit, P., Al-Malah, K., and McGuire, J. (1993) On evaluating the emulsifying properties of protein using conductivity measurements. Food Hydrocolloids 7, 241-253.
19. Talmadge, J. E. (1993). The pharmaceutics and delivery of therapeutic polypeptides and proteins. Adv. Drug Delivery Rev. 10, 247-299.