Outpatient antimicrobial protocol for febrile neutropenia: A nonrandomized prospective trial using ceftriaxone, amikacin, and oral adjuvant agents

Pediatric Hematology and Oncology

Volumn 14, Issue 3, 1997, Pages 205-211

  Sahu, S ^a,b   Bapna, A ^a   Pai, S K ^a   Nair, C N ^a   Kurkure, P A ^a   Advani, S H ^a  

^a TATA MEMORIAL HOSPITAL   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

antimicrobial; febrile neutropenia; outpatient

Indexed keywords

ACICLOVIR; ADJUVANT; AMIKACIN; ANTIBIOTIC AGENT; CEFTRIAXONE; FLUCONAZOLE; METRONIDAZOLE;

ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD CANCER; CLINICAL PROTOCOL; CLINICAL TRIAL; COST CONTROL; FEMALE; FEVER; HEMATOLOGIC DISEASE; HUMAN; INFECTIOUS COMPLICATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; OUTPATIENT CARE;

EID: 0030974372     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.3109/08880019709009490     Document Type: Article

References (24)

1. Pizzo P, Hathorn J, Hiemenz J, et al. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with febrile neutropenia. N Engl J Med 1986;315:552.
2. Pizzo P, Robichaud K, Edwards B, et al. Oral antibiotic prophylaxis in patients with cancer. A double blind randomized placebo controlled trial. J Pediatr. 1983;102:125.
3. Sanders J, Powe N, Moure R. Ceftazidime monotherapy for empiric treatment of febrile neutropenic patients: a meta-analysis. J Infect Dis. 1992;164:907.
4. Wood M, Newland A. Intravenous ciprofloxacin in the management of infections in immunocompromised patients. J Antimicrob Chemother 1986;18:175.
5. Freifeld AS, Infectious complications in the immunocompromised host. The antimicrobial armamentarium. Hematol Oncol Clin North Am. 1993;7:813-839.
6. Lee JW, Pizzo PA. Management of the cancer patient with fever and prolonged neutropenia. Hematol Oncol Clin North Am. 1993;7:937-960.
7. Shepp DH, Newton BA, Dandlikar PS. et al. Oral acyclovir therapy for mucocutaneous herpes simplex virus infections in immuno-compromised marrow transplant recipients. Ann Intern Med. 1985;102:783.
8. Balfour HJ, Bean B, Laskin O, et at. Acyclovir halts progression of herpes zoster in immunocompromised patients. N Engl J Med. 1983;308:1448.
9. Huges WT, Kuhn S, Chaudhary SC, et al. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977;297:1419.
10. Yeo E, Alvarado T, Fainstein V, Bodey G. Prophylaxis of oropharyngeal candidiasis with clotrimazole. J Clin Oncol. 1985;3:1668-1671.
11. Schubtman LB, Funaro L, Robin T, et al. Clotrimazole treatment of oral candidiasis in patients with neoplaslic disease. Am J Med. 1984;76:91-94.
12. Feusner J, Cohen R, O'Leary M, Beach B. Use of routine chest radiography in the evaluation of fever in neutropenic paediatric oncology patients. J Clin Oncol. 1988;11:1699-1702.
13. Huges WT, Bodey GP, Meyers JD, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J Infect Dis 1990;161:381.
14. Pizzo PA, Rubin M, Freifeld A, et al. The child with cancer and infection. I. Empiric therapy for fever and neutropenia and preventive strategies. J Pediatr. 1991;119:679.
15. Cohen K, Stork L, Cullen J, et al. Discontinuation of antibiotic before neutrophil recovery in patients with febrile neutropenia and no identifiable source. Proc Am Soc Clin Oncol. 1992;12:380.
16. Buchanan GR. Approach to treatment of the febrile cancer patient with low-risk neutropenia. Hematol Oncol Clin North Am. 1993;7:919-935.
17. Pyke KG, Kelsey SM, Newland AC. Outpatient treatment of Hickman catheter infections. Lancet. 1992;339:1237.
18. Rubenstein E, Rolston K, Mureland B, et al. Ambulatory treatment of febrile episodes in neutropenic patients. Proc Am Soc Clin Oncol. 1990;9:321.
19. Huges WT, Bodey GP, Meyers JD, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J Infect Dis. 1990;161.381.
20. Mullen CA, Buchanan GR. Early hospital discharge of children with cancer treated for fever and neutropenia: identification and management of the low risk patient. J Clin Oncol. 1990;8:1998,
21. Malik IA, Abbas Z, Karim M. Randomized comparison of oral ofloxacin alone with combination of parenteral antibiotics in neutropenic febrile patients. Lancet. 1992;339:1092.
22. Doyele J, Lau R, King SM, et al. Cost comparison of early discharge of febrile neutropenic patients by substitution of oral for I.V. antibiotics. Blood. 1991;78(suppl 1):153.
23. Pizzo PA, Robichaud KJ, Gill FA, et al. Duration of empiric antibiotic therapy in granulocytopenic patients with cancer. Am J Med. 1979;67:194.
24. Pizzo PA, Robichaud KJ, Gill FA, Whitebsky FG. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med. 1982;72:101-111.