An investigation into the role of rat skeletal muscle as a site for xenobiotic metabolism using microsomes and isolated cells

Human & Experimental Toxicology

Volumn 16, Issue 3, 1997, Pages 138-145

  Crosbie, Sarah J ^a   Blain, P G ^a   Williams, Faith M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

metabolism myopathy; myoblast; n Hexane; skeletal muscle

Indexed keywords

CYTOCHROME P450; ETHOXYRESORUFIN; HEXANE; HEXANOL; OXYGENASE; PENTOXYRESORUFIN; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MICROSOME; CONTROLLED STUDY; DEALKYLATION; ENZYME ACTIVITY; EXTENSOR DIGITORUM LONGUS MUSCLE; IMMUNOCYTOCHEMISTRY; LIVER MICROSOME; MALE; MICROSOME; MUSCLE METABOLISM; MYOBLAST; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE; XENOBIOTIC METABOLISM;

ANIMALS; BRAIN; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEXANES; HEXANOLS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; METHYL N-BUTYL KETONE; MICROSOMES; MICROSOMES, LIVER; MUSCLE, SKELETAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0030973973     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701600302     Document Type: Article

References (25)

1. Spencer PS, Schaumburg HH, Sabri MI, Veronesi B. The enlarging view of hexacarbon neurotoxicity. CRC Critical Reviews of Toxicology 1980; 7: 279-356.
2. Towfighi J. et al. Glue sniffer's neuropathy. Neurology 1976; 26: 238-43.
3. Scelsi R., Poggi P., Fera L., Gonella G. Toxic polyneuropathy due to n-hexane. Journal of the Neurological Sciences 1980; 47: 7-19.
4. Couri D., Milks M. Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone and 2,5-hexanedione. Annual Review of Pharmacology and Toxicology 1982; 22: 145-66.
5. Bastone A. et al. Cholinesterases in blood plasma and tissues of rats treated with n-hexane or with its neurotoxic metabolite 2,5-hexanedione. Archives of Toxicology 1987; 61: 138-44.
6. Braun M., Haydon DA, Murrell RD The effects of n-alcohols on the nicotinic acetylcholine receptor channel in cultured rat myotubes. Journal of Physiology-London 1989; 418: 37P.
7. Huang J. et al. Effects of chronic n-hexane exposure on nervous system-specific and muscle-specific proteins. Archives of Toxicology 1989; 63: 381-5.
8. Hawthorn MH et al. Effect of an homologous series of aliphatic alcohols on neuronal and smooth muscle voltage-dependent Ca2+ channels. European Journal of Pharmacology 1992; 229: 143-8.
9. Toftgård R., Haaparanta T., Eng L., Halpert J. Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. Biochemical Pharmacology 1986; 35: 3733-8.
10. Battershill JM, Illing Hpa, Shillaker RO, Smith AM n-Hexane. Health & Safety Executive Toxicity Review 18, HMSO 1987.
11. Serabjit-Singh CJ, Bend JR, Philpot RM Cytochrome P-450 monooxygenase system. Localisation in smooth muscle of rabbit aorta. Molecular Pharmacology 1985; 28: 72-9.
12. Crosbie SJ, Blain PG, Williams FM Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochromes P-450 inducers. Human and Experimental Toxicology 1997; in press.
13. Veronesi B., Peterson ER, Spencer PS Reproduction and analysis of methyl n-butyl ketone neuropathy in organotypic tissue culture. Experimental and Clinical Neurotoxicology. Editors, Spencer PS, Schaumburg HH. Williams and Wilkins, Baltimore/London. 1980.
14. Lowry OH, Roseborough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265-75.
15. Blau HM, Webster C. Isolation and characterisation of human muscle cells. Proceedings of the National Academy of Sciences USA 1981; 79: 5623-7.
16. Knudsen KA Cell adhesion molecules in myogenesis. Current Opinions in Cell Biology 1990; 2: 902-6.
17. Burke MD, Mayer RT Ethoxyresorufin in direct fluorometric assay of a microsomal O-deethylation which is preferentially inducible by 3-methylchlanthrene. Drug Metabolism and Disposition 1974; 2: 583-8.
18. Rettie AE, Williams FM, Rawlins MD, Burke MD Major differences between lung, skin and liver in the microsomal metabolism of a homologous series of phenoxazone and coumarin ethers. Biochemical Pharmacology 1986; 35: 3495 - 500.
19. Gasnier F. et al. Investigation of glycosilation processes in mitochondria and microsomal membranes from human skeletal muscle. Clinica Chimica Acta 1991; 199: 69-82.
20. McCallum GP, Horton JE, Falkner KC, Bend JR Microsomal cytochrome P-450 1A1 dependent monooxygenase activity in guinea pig heart: induction, inhibition and increased activity by addition of exogenous NADPH-cytochrome P-450 reductase. Canadian Journal of Physiology and Pharmacology 1992; 71: 151-6.
21. Stryer L. Biochemistry. 2nd edition. WH Freeman and Company, New York. 1981.
22. Reiners, Jr. JJ, Cantu AR, Pavone A. Modulation of constitutive cytochrome P-450 expression in vivo and in vitro in murine keratinocytes as a function of differentiation and extracellular Ca2+ concentration. Proceedings of the National Academy of Sciences USA 1990; 87: 1825-9.
23. Guo J-F., Brown R., Rothwell CE, Bernstein IA Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase (AHH) are higher in differentiated than in germinative cutaneous keratinocytes. Journal of Investigative Dermatology, 1990; 94: 86-93.
24. Alvarez J., Montero M., Garcia-Sancho J. Cytochrome P-450 may regulate plasma membrane Ca2+ permeability according to the filling state of the intracellular Ca2+ stores. FASEB Journal 1992; 6: 786 -92.
25. Livingstone I., Johnson MA, Mastaglia FL Effects of dexamthasone on fibre subtype in rat muscle. Neuropathology and Applied Neurobiology 1981; 7: 381- 98.