Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: A new modality treatment

International Journal of Radiation Oncology Biology Physics

Volumn 37, Issue 3, 1997, Pages 499-504

  Fatigante, Lucia ^b   Ducci, F ^b   Cartei, F ^b   Colosimo, S ^b   Marini, C ^b   Prediletto, R ^b   Danesi, R ^b   Laddaga, Michele ^b   Del Tacca, M ^b   Caciagli, P ^a  

^a UNIVERSITY OF PISA   (Italy)

^b NONE

Author keywords

Carbogen; Glioblastoma; Nicotinamide; Radiotherapy

Indexed keywords

CARBOGEN; NICOTINAMIDE;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; GLIOBLASTOMA; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; MULTIMODALITY CANCER THERAPY; ORAL DRUG ADMINISTRATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; SURVIVAL TIME;

ADMINISTRATION, INHALATION; ADULT; AGED; CARBON DIOXIDE; COMBINED MODALITY THERAPY; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; NIACINAMIDE; OXYGEN; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; SUPRATENTORIAL NEOPLASMS; SURVIVAL RATE;

EID: 0030973879     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(96)00605-0     Document Type: Article

References (23)

1. Brown, J. M. Evidence for acutely hypoxic cells in mouse tumors and a possible mechanism of reoxygenation. Br. J. Radiol. 52:650-656; 1979.
2. Cartei, F.; Danesi, R.; Ducci, F.; Fatigante, L. Pharmacokinetics and tolerance of nicotinamide combined with radiation therapy in patients with glioblastoma multiforme. Acta Oncol. 33:969-973; 1994.
3. Cartei, F.; Fatigante, L.; Ducci, F.; Laddaga, M. Nicotinamide tolerance and side effects in 28 patients affected by glioblastoma and treated with radiation therapy (Abstr.). In: The tumor microenvironment, vol. 1. Granada; 1994:37.
4. Catteral, M.; Bloom, H. J.; Ash, D. V.; et al. Fast neutron compared with magavoltage x-rays in the treatment of patients with supratentorial glioblastoma: A controlled pilot study. Int. J. Radiat Oncol. Biol. Phys. 6:261-266; 1980.
5. Chang, C. H. Hyperbaric oxygen as a radiation sensitizer in treatment of malignant gliomas. In: Chang, C. H.; Housepian, E. M., eds. Tumors of the central nervous system: Modern radiotherapy in multidisciplinary management. New York: Mason Publishing, Co.; 1982:23-30.
6. Chaplin, D. J.; Durand, R. E.; Olive, P. L. Acute hypoxia in tumors: Implications for modifiers of radiation effects. Int. J. Radiat. Oncol. Biol. Phys. 12:1279-1282; 1986.
7. Chaplin, D. J.; Horsmann, M. R.; Trotter, M. J. The effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. J. Natl. Cancer Inst. 82:672-676; 1990.
8. Chaplin, D. J.; Peters, C. E.; Horsmann, M. R.; Trotter, M. Drug induced perturbations in tumor blood flow: Therapeutic potential and possible limitations. Radiother. Oncol. 20:93-101; 1991.
9. Dische, S. The clinical use of hyperbaric oxygen and chemical hypoxic cell sensitizers. In: Steel, G. G.; Adams, G. E.; Peckham, M. J., eds. The biological basis of radiotherapy. Amsterdam: Elsevier; 1983:225-237.
10. Ducci, F.; Fabrini, M. G.; Lutzemberg, L.; Cartei, F.; Silvano, G.; Laddaga, M. Supratentorial malignant gliomas: Results in 280 cases treated by postoperative radiotherapy. Cancer J. 6(3): 163-169; 1993.
11. Fatigante, L.; Cartei, F.; Ducci, F.; Marini, C.; Prediletto, R.; Caciagli, P.; Laddaga, M. Carbogen breathing in patients with glioblastoma multiforme submitted to radiotherapy. Assessment of gas exchange parameters. Acta Oncol. 33:807-811; 1994.
12. Gray, L. H.; Conger, A. D.; Ebert, M.; Hornsey, S.; Scott, O. C. A. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. B. J. Radiol. 26:628-648; 1953.
13. Horsmann, M. R. Nicotinamide and the hypoxia problem. Radiother. Oncol. 22:79-80; 1991.
14. Horsmann, M. R.; Chaplin, D. J.; Brown, J. M. Tumor radiosensitization by nicotinamide: A result of improved perfusion and oxygenation. Radiat. Res. 118:139-150; 1989.
15. Keim, H.; Potthoff, P. C.; Schmidt, K.; Schiebusch, M.; Neiss, A.; Trott, K. R. Survival and quality of life after continuous accelerated radiotherapy of glioblastoma. Radiother. Oncol. 9:21-26; 1987.
16. Kjellen, E.; Joiner, M. C.; Collier, J. M.; Johns, H.; Rojas, A. A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated xray treatments. Radiother. Oncol. 22:81-91; 1991.
17. Kruuv, J. A.; Inch, W. R.; McCredie, J. A. Blood flow and oxygenation of tumors in mice. Cancer 20:51-59; 1967.
18. Laramore, G. E.; DienerWest, M.; Griffin, T. W.; Nelson, J. S.; et al. Randomised neutron dose searching study for malignant gliomas of the brain: results of an RTOG study. Int. J. Radiat. Oncol. Biol. Phys. 14:1093-1102; 1988.
19. Leibel, S. A.; Sheline, G. A. Radiation therapy for neoplasms of the brain. J. Neurosurg. 66:122; 1987.
20. Nunn, J. F. Distribution of pulmonary ventilation and perfusion. In: Applied respiratory physiology, 3rd ed. Cambridge, UK: Butterworths & Co.; 1987:40-83.
21. Rojas, A. Radiosensitization with normobaric oxygen and carbogen. Radiother. Oncol. 20:65-70; 1991.
22. Shibamoto, Y.; Yamashita, J.; Takahaski, M.; Yanasaki, T.; Kikuchi, H.; Abe, M. Supratentorial malignant gliomas: an analysis of radiation therapy in 178 cases. Radiother. Oncol. 18:17; 1990.
23. Urtasun, R.; Feldstein, M. L.; Partington, J.; et al. Radiation and nitroimidazoles in supratentorial highgrade gliomas: A second clinical trial. Br. J. Cancer 46:101-108; 1982.