The MEF2A 3' untranslated region functions as a cis-acting translational repressor

Molecular and Cellular Biology

Volumn 17, Issue 5, 1997, Pages 2756-2763

  Black, Brian L ^a   Lu, Jianrong ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCLE PROTEIN; MYOCYTE ENHANCER FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HAMSTER; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPRESSOR GENE; RNA TRANSLATION; SEQUENCE ANALYSIS; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALIA; CRICETINAE; FELIS CATUS; ORYCTOLAGUS CUNICULUS;

EID: 0030973866     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.5.2756     Document Type: Article

References (40)

1. Black, B. L., and D. S. Lyles. 1992. Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo. J. Virol. 66: 4058-4064.
2. Black, B. L., J. F. Martin, and E. N. Olson. 1995. The mouse MRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors. J. Biol. Chem. 270:2889-2892.
3. Black, B. L., K. L. Ligon, Y. Zhang, and E. N. Olson. 1996. Cooperative transcriptional activation by the neurogenic bHLH protein MASH1 and members of the MEF2 family. J. Biol. Chem. 271:26659-26663.
4. Black, B. L., and E. N. Olson. Unpublished observations.
5. Breibart, R., C. Liang, L. B. Smoot, D. Laheru, V. Mahdavi, and B. Nadal-Ginard. 1993. A fourth human MEF-2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development 118:1095-1106.
6. Buchberger, A., K. Ragge, and H. H. Arnold. 1994. The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2. J. Biol. Chem. 269:17289-17296.
7. Chambers, A. E., S. Kotecha, N. Towers, and T. J. Mohun. 1992. Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis. EMBO J. 11:4981-4991.
8. Davis, S., and J. C. Watson. 1996. In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3′ untranslated regions of human α-tropomyosin. Proc. Natl. Acad. Sci. USA 93:508-513.
9. Decker, C. J., and R. Parker. 1995. Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts. Curr. Opin. Cell Biol. 7:386-392.
10. Dodou, E., D. B. Sparrow, T. Mohun, and R. Treisman. 1996. MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells. Nucleic Acids Res. 23:4267-4274.
11. Edmondson, D. G., G. E. Lyons, J. F. Martin, and E. N. Olson. 1994. MEF2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120:1251-1263.
12. Gossett, L. A., D. J. Kelvin, E. A. Sternberg, and E. N. Olson. 1989. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol. 9:5022-5033.
13. Horton, R. M. 1993. In vitro recombination and mutagenesis of DNA, p. 251-261. In B. A. White (ed.), PCR protocols: current methods and applications, vol. 15. Humana Press, Inc., Totowa, N.J.
14. Kaushal, S., J. W. Schneider, B. Nadal-Ginard, and V. Mahdavi. 1994. Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science 266:1236-1240.
15. Krieg, P. A., and D. A. Melton. 1984. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res. 12:7057-7070.
16. Kruys, V., and G. Huez. 1994. Translational control of cytokine expression by 3′ UA-rich sequences. Biochimie 76:862-866.
17. L'Ecuyer, T. J., P. C. Tompach, E. Morris, and A. B. Fulton. 1995. Transdifferentiation of chicken embryonic cells into muscle cells by the 3′ untranslated region of muscle tropomyosin. Proc. Natl. Acad. Sci. USA 92:7520-7524.
18. Leifer, D., J. Golden, and N. W. Kowall. 1994. Myocyte-specific enhancer binding factor 2C expression in human brain development. Neuroscience 63:1067-1079.
19. Leifer, D., D. Krainc, Y. T. Yu, J. C. McDermott, R. Breibart, J. Heng, R. L. Neve, B. Kosofsky, B. Nadal-Ginard, and S. A. Lipton. 1993. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc. Natl. Acad. Sci. USA 90:1546-1550.
20. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
21. Lyons, G. E., B. K. Micales, J. J. Schwarz, J. F. Martin, and E. N. Olson. 1995. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J. Neurosci. 15:5727-5738.
22. Mao, Z., and B. Nadal-Ginard. 1996. Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. J. Biol. Chem. 271:14371-14375.
23. Martin, J. F., J. M. Miano, C. M. Hustad, N. G. Copeland, N. A. Jenkins, and E. N. Olson. 1994. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol. Cell. Biol. 14:1647-1656.
24. Martin, J. F., J. J. Schwarz, and E. N. Olson. 1993. Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. USA 90:5282-5286.
25. McCarthy, J. E. G., and H. Kollmus. 1995. Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. Trends Biochem. Sci. 20:191-197.
26. McDermott, J. C., M. C. Cardoso, Y. T. Yu, V. Andres, D. Leifer, D. Krainc, S. A. Lipton, and B. Nadal-Ginard. 1993. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol. Cell. Biol. 13:2564-2577.
27. Molkentin, J. D., B. L. Black, J. F. Martin, and E. N. Olson. 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83:1125-1136.
28. Olson, E. N., M. Perry, and R. A. Schulz. 1995. Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev. Biol. 172:2-14.
29. Pollock, R., and R. Treisman. 1991. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 5:2327-2341.
30. Rastinejad, F., and H. M. Blau. 1993. Genetic complementation reveals a novel regulatory role for 3′ untranslated regions in growth and differentiation. Cell 72:903-917.
31. Rastinejad, F., M. J. Conboy, T. A. Rando, and H. M. Blau. 1993. Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin. Cell 75:1107-1117.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
33. Sonenberg, N. 1994. mRNA translation: influence of the 5′ and 3′ untranslated regions. Curr. Opin. Genet. Dev. 4:310-315.
34. Standart, N., and R. J. Jackson. 1994. Regulation of translation by specific protein/mRNA interactions. Biochimie 76:867-879.
35. Subramanian, S. V., and B. Nadal-Ginard. 1996. Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Mech. Dev. 57:103-112.
36. Suzuki, E., K. Guo, M. Kolman, Y. T. Yu, and K. Walsh. 1995. Serum induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation. Mol. Cell. Biol. 15:3415-3423.
37. Suzuki, E., J. Lowry, G. Sonoda, J. R. Testa, and K. Walsh. 1996. Structure and chromosomal locations of the human MEF2A gene and a pseudogene MEF2AP. Cytogenet. Cell. Genet. 73:244-249.
38. Wahle, E. 1995. 3′-end cleavage and polyadenylation of mRNA precursors. Biochim. Biophys. Acta 1261:183-194.
39. Wahle, E., and W. Keller. 1992. The biochemistry of 3′-end cleavage and polyadenylation of messenger RNA precursors. Annu. Rev. Biochem. 61: 419-440.
40. Yu, Y. T., R. E. Breibart, L. B. Smoot, Y. Lee, V. Mahdavi, and B. Nadal-Ginard. 1992. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 6:1783-1798.