Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men

Metabolism: Clinical and Experimental

Volumn 46, Issue 5, 1997, Pages 526-529

  Pasquali, Renato ^a   Macor, Cinzia ^b   Vicennati, Valentina ^b   Novo, Francesca ^b   De Lasio, Rosaria ^b   Mesini, Paolo ^b   Boschi, Stefano ^b   Casimirri, Francesco ^b   Vettor, Roberto ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; INSULIN; PRASTERONE SULFATE; TESTOSTERONE;

ADULT; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; HORMONE DETERMINATION; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; OBESITY; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE METABOLISM; TESTOSTERONE RELEASE;

EID: 0030973135     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90189-X     Document Type: Article

References (25)

1. Seidell JC, Bjorntorp P, Sjostrom L, et al: Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 39:897-901, 1990
2. Pasquali R, Casimirri F, Cantobelli S, et al: Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism 40:101-104, 1991
3. Haffner SM, Valdez RA, Stern MP, et al: Obesity, body fat distribution and sex hormones in men. Int J Obes 17:643-649, 1993
4. Strain GW, Zumoff B, Kream J, et al: Mild hypogonadotropic hypogonadism in obese men. Metabolism 31:871-875, 1982
5. Glass AR, Swerdloff RS, Bray GA, et al: Low serum testosterone and sex hormone-binding globulin in massively obese men. J Clin Endocrinol Metab 45:1211-1219, 1977
6. Vermeulen A, Kaufmann JM, Deslypere JP, et al: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 76:1140-1146, 1993
7. Killinger DW, Perel E, Daniilescu D, et al: The relationship between aromatase activity and body fat distribution. Steroids 50:61-72, 1987
8. Poretsky L, Kalin MF: The gonadotropic function of insulin. Endocr Rev 8:132-141, 1987
9. Poretsky L: On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr Rev 12:3-13, 1991
10. Plymate SR, Matej LA, Jones RE, et al: Inhibition of sex hormone-binding globulin in the human hepatoma (HepG2) cell line by insulin and prolactin. J Clin Endocrinol Metab 67:460-464, 1988
11. Nestler JE, Barlascini CO, Matt DW, et al: Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 68:1027-1032, 1989
12. Nestler JE: Editorial. Sex hormone-binding globulin: A marker for hyperinsulinemia and/or insulin resistance? J Clin Endocrinol Metab 76:273-274, 1993
13. Pasquali R, Casimirri F, De Iasio R, et al: Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab 80:654-658, 1995
14. De Fronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
15. Bonora E, Del Prato S, Bonadonna RC, et al: Total body fat content and fat topography are associated differently with in vivo glucose metabolism in non obese and obese non diabetic women. Diabetes 41:1151-1159, 1992
16. Steele R: Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430, 1959
17. Boschi S, De Iasio R, Mesini P, et al: Measurement of steroid hormones in plasma by isocratic high performance liquid chromatography coupled with radioimmunoassay. Clin Chim Acta 231:107-113, 1994
18. Van Cauter E, Aschoff J: Endocrine and other biological rhythms, in De Groot LJ (ed): Endocrinology, vol 3. Philadelphia, PA, Saunders, 1989, pp 2658-2705
19. Lin T, Haskell J, Vinson N, et al: Characterization of insulin and insulin-like growth factor I receptors of purified Leydig cells and their role in steroidogenesis in primary cultures: A comparative study. Endocrinology 119:1641-1647, 1986
20. Lopez Blanco F, Fanjul LF, Ruiz de Galarreta CM: The effect of insulin and luteinizing hormone treatment on serum concentrations of testosterone and dihydrotestosterone and testicular 3β-hydroxysteroid dehydrogenase activity in intact and hypophysectomized rats. Endocrinology 109:1248-1253, 1989
21. Adashi EY, Fabics C, Hsueh AJW: Insulin augmentation of testosterone production in a primary culture of rat testicular cells. Biol Reprod 26:270-280, 1982
22. 125I) insulin-like growth factor I binding in the rat. Endocrinology 122:581-585, 1988
23. Dunaif A, Graf M: Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. J Clin Invest 83:23-29, 1989
24. Nestler JE, Clore JN, Strauss III JF, et al: The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulphate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance and acanthosis nigricans. J Clin Endocrinol Metab 64:180-184, 1987
25. Vermeulen A, Kaufmann JM. Deslypere JP, et al: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese males. J Clin Endocrinol Metab 76:1140-1146, 1993