Comparative study of four different pharmacokinetic computer programs: Case study of a factor VIII preparation

European Journal of Clinical Pharmacology

Volumn 52, Issue 1, 1997, Pages 59-64

  Pascual, B ^a,b   Montoro, J B ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b INSTITUT UNIVERSITARI DEXEUS   (Spain)

Author keywords

factor VIII concentrate; haemophilia; pharmacokinetics

Indexed keywords

BLOOD CLOTTING FACTOR 8 CONCENTRATE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER PROGRAM; HEMOPHILIA A; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MODEL; PHARMACOKINETICS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; COST CONTROL; FACTOR VIII; HEMOPHILIA A; HUMANS; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 0030972289     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050249     Document Type: Article

References (9)

1. Bjorkman S, Carlsson M, Berntorp E, Stenberg P (1992) Pharmacokinetics of factor VIII in humans. Obtaining clinically relevant data from comparative studies. Clin Pharmacokinet 22: 385-395
2. Messori A, Longo G, Mattucci M, Morfini M, Rossi-Ferrini PL (1987) Clinical pharmacokinetics of factor VIII in patients with classic haemophilia. Clin Pharmacokinet 13: 365-380
3. Mannucci PM, Morfini M (1990) Determination of pharmacokinetics of replacement factor VIII. Semin Hematol 27 (Suppl 2): 8-10
4. Messori A, Morfini M, Blomback M, Cinotti S, Longo G, Schimpf K, Schumacher K, Novakova-Banet A, Delvos U, Kjellman H (1992) Pharmacokinetics of two pasteurised factor VIII concentrates by different and multicenter assay of factor VIII activity. Thromb Res 65: 699-708
5. Cinotti S, Longo G, Messori A, Morfini M, Blomback M, Schimf K (1991) Reproducibility of one-stage, two-stage and chormogenic assays of factor VIII activity: A multicenter study. Thromb Res 61: 385-393
6. Finney DJ (1976) A computer program for parallel line bioassay. J Pharmacol Exp Ther 198: 497-506
7. Messori A, Longo G, Matucci M, Morfini M, Rossi-Ferrini PL (1988) Multivariate analysis of factor governing the pharmacokinetics of exogenous factor VIII in hemophiliacs. Eur J Clin Pharmacol 35: 663-668
8. Shumaker RC (1986) PKCALC: a BASIC interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metab Rev 17: 331-348
9. Morfini M, Messori A, Longo G (1990) Recommendations for pharmacokinetic study of clotting factor concentrates. Preliminary report of ICTH. Subcommittee on factor VIII and factor IX. Barcelona. June 20 21th, 1-10