α-Anordrin-induced apoptosis of leukemia K562 cells is not prevented by cycloheximide

Acta Pharmacologica Sinica

Volumn 18, Issue 2, 1997, Pages 169-172

  Lou, Li Guang ^a   Xu, Bin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

anordrin; cultured tumor cells; cycloheximide; DNA damage; leukemia K562

Indexed keywords

ALPHA ANORDRIN; CYCLOHEXIMIDE; DNA; DNA FRAGMENT; POSTCOITUS CONTRACEPTIVE AGENT; PROTEIN SYNTHESIS INHIBITOR; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL STRAIN K 562; CELL STRUCTURE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CYCLOHEXIMIDE; DNA, NEOPLASM; HUMANS; K562 CELLS; NORANDROSTANES; PROTEIN SYNTHESIS INHIBITORS; TUMOR CELLS, CULTURED;

EID: 0030971889     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984; 142: 67-77.
2. Ling YH, Priebe W, Perez-Soler R. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. Cancer Res 1993; 53: 1845-52.
3. Tsuchida H, Takeda Y, Takei H, Shinzawa H, Takahashi T, Sendo F. In vivo regulation of rat neutrophil apoptosis occuring spontaneously or induced with TNF-α or cycloheximide. J Immunol 1995; 154: 2403-12.
4. Takano YS, Harmon BV, Kerr JFR. Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: a study using election microscopy and DNA gel eletrophoresis. J Pathol 1991; 163: 329-36.
5. Lou LG, Xu B. Induction of apoptosis in human leukemia K562 cells by α-anordrin. Acta Pharmacol Sin 1996; 17: 255-8.
6. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiwicz Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 1993; 53: 3186-92.
7. Kalemkerian GP, Slusher R, Ramalingam S, Gadgeel S, Mabry M. Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines. J Natl Cancer Inst 1995; 87: 1674-80.
8. Kamesaki S, Kamesaki H, Jorgensen TJ, Tanizawa A, Pommier Y, Cossman J. bcl-2 Protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair. Cancer Res 1993; 53: 4251-6.
9. Piazza GA, Rahm ALK, Krutzsch M, Sperl G, Paranka NS, Gross PH, et al. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res 1995; 55: 3110-6.
10. Sellins KS, Cohen JJ. Gene induction by γ-irradiation leads to DNA fragmentation on lymphocytes. J Immunol 1987; 139: 3199-206.
11. 2+-mediated endonuclease activation. Science 1988; 242: 256-9.
12. Martin SJ, Lennon SV, Bonham AM, Cotter TG. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J Immunol 1990; 145: 1859-67.
13. Collins RJ, Harmon BV, Souvlis T, Pope JH, Kerr JFR. Effects of cycloheximide on B-chronic lymphocytic leukaemic and normal lymphocytes in vitro: induction of apoptosis. Br J Cancer 1991; 64: 518-22.
14. Cohen JJ. Apoptosis. Immunol Today 1993; 14: 126-30.
15. 1 phase. Acta Pharmacol Sin 1994; 15: 47-50.