Physiology and pharmacology of neuropathic pain

Anesthesiology Clinics of North America

Volumn 15, Issue 2, 1997, Pages 335-352

  Yaksh, T L ^a   Chaplan, S R ^a  

^a School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR ANTAGONIST; LOCAL ANESTHETIC AGENT; OPIATE AGONIST;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION REGULATION; NERVE CONDUCTION; NERVE SPROUTING; NONHUMAN; PAIN; PERIPHERAL NERVE INJURY; PHYSIOLOGY; REVIEW; SECOND MESSENGER; SENSORY NERVE; SPINAL CORD DORSAL HORN; SPINAL GANGLION;

EID: 0030971113     PISSN: 08898537     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8537(05)70337-0     Document Type: Article

References (91)

1. S.C. Ahlgren J.D. Levine Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat J Neurophysiol 72 1994 684 692
2. S. Arnér B.A. Meyerson Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain Pain 33 1988 11 23
3. F.W. Bach S.R. Chaplan J. Jang Cerebrospinal fluid β-endorphin in models of hyperalgesia in the rat Regul Pept 59 1995 79 86
4. F.W. Bach S.R. Chaplan T.L. Yaksh Studies on the spinal pharmacology of a new model of allodynia Ann Neurol 36 1994 288A
5. G.J. Bennett Y.-K. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
6. D. Besse M.C. Lombard J.M. Besson Time-related decreases in mu and delta opioid receptors in the superficial dorsal horn of the rat spinal cord following a large unilateral dorsal rhizotomy Brain Res 578 1992 115 127
7. D. Besse M.C. Lombard S. Perrot Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: Comparison with sciatic nerve section and lumbar dorsal rhizotomy Neuroscience 50 1992 921 933
8. D. Bouhassira [Changes in spinal dorsal horn induced by peripheral nerve involvement] Can Anesthesiol 42 1994 689 697
9. D. Bowsher Sensory change in postherpetic neuralgia C.P.N. Watson Herpes Zoster and Postherpetic Neuralgia 1993 Elsevier Science Publishers BV Amsterdam 97 107
10. A.A. Cameron K.D. Cliffer P.M. Dougherty Changes in lectin, GAP-43 and neuropeptide staining in the rat dorsal horn following experimental peripheral neuropathy Neurosci Lett 131 1991 249 252
11. J.N. Campbell S.N. Raja R.A. Meyer Myelinated afferents signal the hyperalgesia associated with nerve injury Pain 32 1988 89 94
12. S.R. Chaplan F.W. Bach S.L. Shafer Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats Anesthesiology 83 1995 775 785
13. Chaplan SR, Calcutt NA: Pharmacology of tactile allodynia in the streptozotocin diabetic rat. AUA Satellite Symposium, Horizons in Pain Research, San Diego, 1995
14. Chaplan SR, Pogrel JW, Bach FW, et al: Spinal pharmacology of tactile allodynia in Chung neuropathy rats. Scandinavian Association for the Study of Pain, 18th Annual Meeting, Lillehammer, Norway, 1994
15. S.R. Chaplan J.W. Pogrel T.L. Yaksh Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia J Pharmacol Exp Ther 269 1994 1117 1123
16. K. Chatani M. Kawakami J.N. Weinstein Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion Spine 20 1995 277 290
17. L. Chen L.Y.M. Huang Sustained potentiation of NMDA receptor mediated glutamate responses through activation of protein kinase C by a mu-opioid Neuron 7 1991 319 326
18. 2+ block of NMDA-receptor channels as a mechanism of modulation Nature 356 1992 521 523
19. S.I. Chi J.D. Levine A.I. Basbaum Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat Brain Res 617 1993 225 237
20. K. Chung H.J. Kim H.S. Na Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain Neurosci Lett 162 1993 85 88
21. T.J. Coderre The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in rats Molec Neurobiol 7 1993 229 246
22. T.J. Coderre R. Melzack Central neural mediators of secondary hyperalgesia following heat injury in rats: Neuropeptides and excitatory amino acids Neurosci Lett 131 1991 71 74
23. T.J. Coderre K. Yashpal Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model Eur J Neurosci 6 1994 1328 1334
24. M.J. Cumberbatch J.F. Herrero P.M. Headley Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli Neurosci Lett 181 1994 98 102
25. G. Davar A. Hama A. Deykin MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy Brain Res 553 1991 327 330
26. M. Devor Neuropathic pain and injured nerve—peripheral mechanisms Br Med Bull 47 1991 619 630
27. M. Devor R. Govrin-Lippmann Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves Pain 16 1983 73 85
28. + channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation J Neurosci 13 1993 1976 1992
29. M. Devor P.D. Wall Cross-excitation in dorsal root ganglia of nerve-injured and intact rats J Neurophysiol 64 1990 1733 1746
30. M. Devor P.D. Wall N. Catalan Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction Pain 48 1992 261 268
31. A.H. Dickenson Central acute pain mechanisms Ann Med 27 1995 223 227
32. A.H. Dickenson A.F. Sullivan Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones Neurosci Lett 83 1987 207 211
33. P.M. Dougherty C.J. Garrison S.M. Carlton Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat Brain Res 570 1992 109 115
34. R. Dubner M.A. Ruda Activity-dependent neuronal plasticity following tissue injury and inflammation Trends Neurosci 15 1992 96 103
35. J.C. Eisenach S. DuPen M. Dubois Epidural clonidine analgesia for intractable cancer pain: The Epidural Clonidine Study Group Pain 61 1995 391 399
36. C.J. Garrison P.M. Dougherty S.M. Carlton Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated rats Brain Res 607 1993 205 214
37. C.J. Garrison P.M. Dougherty K.C. Kajander Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury Brain Res 565 1991 1 7
38. M.G. Garry K.C. Kajander G.J. Bennett Quantitative autoradiographic analysis of [125I]-human CGRP binding sites in the dorsal horn of rat following chronic constriction injury or dorsal rhizotomy Peptides 12 1991 1365 1373
39. R. Govrin-Lippmann M. Devor Ongoing activity in severed nerves: Source and variation with time Brain Res 159 1978 406 410
40. K.C. Kajander G.J. Bennett Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons J Neurophysiol 68 1992 734 744
41. J. Kastrup F.W. Bach P. Petersen Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma Clin J Pain 5 1989 239 244
42. S.H. Kim J.M. Chung An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 1992 355 363
43. M. Koltzenburg H.E. Torebjork L.K. Wahren Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain Brain 117 1994 579 591
44. M. Korte P. Carroll E. Wolf Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor Proc Natl Acad Sci USA 92 1995 8856 8860
45. J.D. Kristensen B. Svensson T. Gordh Jr The NMDA-receptor antagonist CPP abolishes neurogenic `wind-up pain' after intrathecal administration in humans Pain 51 1992 249 253
46. R.H. LaMotte C.N. Shain D.A. Simone Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms J Neurophysiol 66 1991 190 211
47. G.R. Lewin A. Rueff L.M. Mendell Peripheral and central mechanisms of NGF-induced hyperalgesia Eur J Neurosci 6 1994 1903 1912
48. D. Lindholm E. Castren M. Berzaghi Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain—implications for neuronal plasticity J Neurobiol 25 1994 1362 1372
49. M.C. Lombard J.M. Besson Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord Pain 37 1989 335 345
50. A.B. Malmberg T.L. Yaksh Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition Science 257 1992 1276 1279
51. A.B. Malmberg T.L. Yaksh Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats Pain 54 1993 291 300
52. A.B. Malmberg T.L. Yaksh The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats Br J Pharmacol 114 1995 1069 1075
53. J. Mao D.D. Price D.J. Mayer Thermal hyperalgesia in association with the development of morphine tolerance in rats: Roles of excitatory amino acid receptors and protein kinase C J Neurosci 14 1994 2301 2312
54. P. Marchettini M. Lacerenza C. Marangoni Lidocaine test in neuralgia Pain 48 1992 377 382
55. E.M. Mclachlan W. Janig M. Devor Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia Nature 363 1993 543 546
56. S.B. McMahon D.L. Bennett J.V. Priestley The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule [see comments] Nat Med 1 1995 774 780
57. S.T. Meller C.L. Dykstra G.F. Gebhart Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors Neuroreport 4 1993 879 882
58. R.L. Nahin K. Ren M. De Leon Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain Pain 58 1994 95 108
59. J. Palecek V. Paleckova P.M. Dougherty Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy J Neurophysiol 67 1992 1562 1573
60. R.W. Presley D. Menétry J.D. Levine Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord J Neurosci 10 1990 323 335
61. D.D. Price S. Long C. Huitt Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy [see comments] Pain 49 1992 163 173
62. S.N. Raja R.A. Meyer J.N. Campbell Peripheral mechanisms of somatic pain Anesthesiology 68 1988 571 590
63. R.L. Rauck J.C. Eisenach K. Jackson Epidural clonidine treatment for refractory reflex sympathetic dystrophy [see comments] Anesthesiology 79 1993 1163 1169
64. A.M. Ritter G.R. Lewin L.M. Mendell Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats Brain Res Bull 30 1993 245 249
65. + channels following axotomy in cutaneous afferent DRG neurons of adult rat Abstracts Society for Neuroscience 21 1995 1819
66. M.C. Rowbotham L.A. Reisnerkeller H.L. Fields Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia Neurology 41 1991 1024 1028
67. J. Sato E.R. Perl Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury Science 251 1991 1608 1610
68. Z. Seltzer R. Dubner Y. Shir A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury Pain 43 1990 205 218
69. D.A. Smith M. Browning T.V. Dunwiddie Cocaine inhibits hippocampal long-term potentiation Brain Res 608 1993 259 265
70. M.L. Sotgiu M. Lacerenza P. Marchettini Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats Somatosens Mot Res 9 1992 227 233
71. C.W. Stevens K.C. Kajander G.J. Bennett Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy Pain 46 1991 315 326
72. T. Sugimoto G.J. Bennett K.C. Kajander Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of a chronic constriction injury, transection, and strychnine Pain 42 1990 205 213
73. D.L. Tanelian M.B. Maclver Analgesic concentrations of lidocaine suppress tonic A-delta and C-fiber discharges produced by acute injury Anesthesiology 74 1991 934 936
74. + channels in spinal cord astrocytes following activation of protein kinase C J Neurosci 13 1993 4889 4897
75. H. Thoenen Neurotrophins and neuronal plasticity Science 270 1995 593 598
76. A.J. Todd A.C. Sullivan Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat J Comp Neurol 296 1990 496 505
77. T.R. Tolle J.M. Castro-Lopes A. Coimbra Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation [published erratum appears in Neurosci Lett 114:239, 1990] Neurosci Lett 111 1990 46 51
78. L.K. Wahren E. Torebjörk Quantitative sensory tests in patients with neuralgia 11 to 25 years after injury Pain 48 1992 237 244
79. S.G. Waxman J.D. Kocsis J.A. Black Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy J Neurophysiol 72 1994 466 470
80. S. Weir-Mitchell G.R. Moorhouse W.W. Keen Gunshot Wounds and Other Injuries of Nerves 1864 JB Lippincott Philadelphia
81. W.F. White A.H. Heller Glycine receptor alteration in the mutant mouse spastic Nature 298 1982 655 657
82. C.J. Woolf P. Shortland R.E. Coggeshall Peripheral nerve injury triggers central sprouting of myelinated afferents Nature 355 1992 75 78
83. 2+ channels and the abnormal electrical activity of demyelinated nerve] Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 14 1992 59 62
84. Y.K. Xie W.H. Xiao H.Q. Li The relationship between new ion channels and ectopic discharges from a region of nerve injury Sci China B 36 1993 68 74
85. T. Yaksh Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists Pain 37 1989 111 123
86. T.L. Yaksh The spinal actions of opioids A. Herz Handbook of Experimental Pharmacology 1993 Springer-Verlag Berlin 53 90
87. T.L. Yaksh The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the postinjury pain state Curr Opin Neurol Neurosurg 6 1993 250 256
88. T.L. Yaksh A.B. Malmberg Spinal actions of NSAIDS in blocking spinally mediated hyperalgesia: The role of cyclooxygenase products Agents Actions 41 suppl 1993 89 100
89. T.L. Yaksh J.W. Pogrel Y.W. Lee Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoreceptor agonists J Pharmacol Exp Ther 272 1995 207 214
90. T. Yamamoto T.L. Yaksh Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction Pain 55 1993 227 233
91. K. Yashpal G.M. Pitcher A. Parent Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C J Neurosci 15 1995 3263 3272