Effects of excess glucose on mammalian post-implantation embryos

International Journal of Developmental Biology

Volumn 41, Issue 2, 1997, Pages 299-306

  Ellington, Stephanie K L ^a  

^a PHYSIOLOGICAL LABORATORY   (United Kingdom)

Author keywords

embryo culture; glucose transporters; hyperglycemia; maternal diabetes; organogenesis

Indexed keywords

ARTICLE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOPATHY; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; MATERNAL DIABETES MELLITUS; NIDATION; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; CULTURE MEDIA; CULTURE TECHNIQUES; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DISEASES; GESTATIONAL AGE; GLUCOSE; MICE; PREGNANCY; PREGNANCY IN DIABETICS; RATS;

EID: 0030971035     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. AKAZAWA, M., AKAZAWA, S., HASHIMOTO, M , AKASHI, M., YAWAZAKI, H., TAHARA, D , YAMAMOTO, H., YAMAGUCHI, Y , NAKANISHI,T. and NAGATAKI, S (1989) Effects of brief exposure to insulin-induced hypoglycemic serum during organogenesis in rat embryo culture Diabetes 38. 1573-1578
2. BAKER, L., PIDDINGTON, R., GOLDMAN, A , EGLER, J. and MOEHRING J (1990) Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos. Diabetologia 33: 593-596.
3. BECERRA, J E , KHOURY, M J., CORDERO, J F and ERICKSON, J D. (1990) Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study. Pediatrics 85: 1 -9
4. BUCHANAN, T.A., DENNO, K M., SIPOS, G.F. and SADLER, T.W. (1994). Diabetic teratogenesis. In vitro evidence for a multifactorial etiology with little contribution from glucose per se Diabetes 43: 656-660.
5. CHRISTIE, G.A. (1966) Implantation of the rat embryo glycogen and alkaline phosphatases. J Reprod Fertii 12: 279-294.
6. CHRISTIE, G.A. (1967). Implantation of the rat embryo, further histochemical observations on carbohydrate, RNA, and lipid metabolic pathways. J Reprod. Fertii 13. 281-296
7. COCKROFT, D.L. (1984) Abnormalities induced in cultured rat embryos by hyperglycaemia Br. J Exp Pathol 65 625-636
8. COCKROFT, D L. (1990). Dissection and culture of postimplantation embryos. In Postimplantation Mammalian Embryos:A Practical Approach(Eds. A.J. Copp and D L. Cockroft) IRL Press, Oxford-New York-Tokyo, pp 15-40
9. COCKROFT, D L. and COPPOLA, P T. (1977). Teratogenic effects of excess glucose on head-fold rat embryos in culture Teratology 16: 141-146.
10. ELLINGTON, SKL (1987a). Development of rat embryos cultured in glucose-deficient media Diabetes 36: 1372-78.
11. ELLINGTON, SKL (1987b) In vitro analysis of glucose metabolism and embryonic growth in postimplantation rat embryos. Development 100: 431-439.
12. ERIKSSON, U.J (1984). Congenital malformations in diabetic animal models - a review. Diabetes Res. 1: 57-66
13. ERIKSSON, U.J. (1988). Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats. Teratology 37: 365-374
14. ERIKSSON,U J and BORG, L.A.H (1988).VII.3 Does hyperglycemia in vitro cause maldevelopment of embryos by deranging their DNA metabolism? In Frontiers in Diabetes Research Lessons from Animal Diabetes (Eds E Shafrir and A.E Renold). John Libbey and Co Ltd., London, pp 418-422.
15. ERIKSSON, U.J and BORG, L A.H (1991). Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro. Diabetologia 34: 325-331.
16. ERIKSSON, U J , NAESER, P. and BROLIN, S E (1986) Increased accumulation of sorbitol in offspring of manifest diabetic rats Diabetes 35: 1356-1363
17. FINN,C.A (1977). The implantation reaction In The Biology of the Uterus (Ed R M. Wynn) Plenum Press, New York-London, pp 245-308
18. FREEMAN, S.J , BECK, F. and LLOYD, J.B (1981) The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro J. Embryol Exp Morphol 66: 223-234.
19. FREEMAN, S.J., BRENT, R.L and LLOYD, J.B. (1982). The effect of teratogenic antiserum on yolk-sac function in rat embryos cultured in vitro. J. Embryol. Exp. Morphol. 77: 63-74.
20. FREINKEL, N. (1980). Of pregnancy and progeny Banting Lecture 1980. Diabetes 29. 1023-1035
21. FRElNKEL, N. (1988). Diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models. Horm. Metab. Res. 20: 463-475.
22. FREINKEL, N , COCKROFT, D.L., LEWIS, N.J., GORMAN, L., AKAZAWA, S., PHILLIPS, L.S. and SHAMBAUGH III, G.E. (1986) The 1986 McCollum award lecture. Fuel-mediated teratogenesis during early organogenesis: the effects of increased concentrations of glucose, ketones, or somatomedin inhibitor during rat embryo culture. Am J. Clin. Nutr. 44: 986-995.
23. FREINKEL, N., LEWIS, N.J., AKAZAWA, S., ROTH, S I. and GORMAN, L (1984). Letter to the Editor: Honeybee syndrome, glycolysis and birth defects. N. Engl J. Med. 310:1536
24. FULOP, M., ROSENBLATT, A., KREITZER, S.M and GERSTEN HABER, B. (1975). Hypersomolar nature of diabetic coma. Diabetes 24: 594-599.
25. GOLDMAN, A.S., BAKER, L., PIDDINGTON, R., MARX, B., HEROLD, R. and EGLER, J. (1985). Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proc Natl. Acad. Sci. USA 82: 8227-8231.
26. +-ATPase regulation involved in pathogenesis of diabetic neuropathy? Diabetes 37: 688-693.
27. HOD, M., STAR, S., PASSONNEAU, J.V., UNTERMAN, T G. and FREINKEL, N (1986) Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis. Biochem. Biophys. Res. Commun. 140: 974-980.
28. HOGAN, A., HEYNER, S., CHARRON, M J., COPELAND, N.G , GILBERT, D J., JENKINS, N A., THORENS, B and SCHULTZ, G.A. (1991). Glucose transporter gene expression in early mouse embryos. Development 113: 363-372.
29. KOSZALKA, T.R , ANDREW, C L , LLOYD, J.B and BRENT, R.L. (1988). Carriermediated uptake of hexoses by the rat visceral yolk sac. Placenta 9. 547-558
30. MILLS, J L. (1982). Malformations in infants of diabetic mothers Teratology 25. 385-394.
31. MUECKLER, M (1994). Facilitative glucose transporters. Eur. J. Biochem. 219: 713-725.
32. NEW, D.A T (1973). Studies on mammalian fetuses in vitro during the period of organogenesis. In The Mammalian Fetus in Vitro (Ed C R. Austin) Chapman and Hall, London, pp. 15-66.
33. NEW, DAT (1978) Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev. 53: 81 -122.
34. NEW, D A T and BRENT, R L. (1972). Effect of yolk-sac antibody on rat embryos grown in culture. J. Embryol. Exp. Morphol. 27: 543-553
35. OLGEMOLLER, B., SCHWAABE, S , SCHLEICHER, E.D. and GERTIBZ, K.D. (1993) Up-regulation of myo-inositol transport compensates for competitive inhibition by glucose. An explanation for the inositol paradox? Diabetes 42: 1119-1125.
36. PADYKULA, H.A , DAREN, J.J. and WILSON, T.M. (1966). Development of structure and function in the mammalian yolk sac. I. Developmental morphology and vitamin B12 uptake of the rat yolk sac. Dev. Biol. 13: 311 -348.
37. PAYNE, G S. and DEUCHAR, E M. (1972). An in vitro study of functions of the embryonic membranes in the rat. J. Embryol Exp. Morphol 27. 533-542.
38. PINTER, E., REECE, E.A., LERANTH, C.Z., GARCIA-SEGURA, M , HOBBINS, J.C., MAHONEY, M.J. and NAFTOLIN, F. (1986a). Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy. Am. J. Obstet. Gynecol. 155: 691-702.
39. PINTER, E., REECE, A.E., LERANTH, C.Z., SANYAL, M.K., HOBBINS, J.C., MAHONEY, M.J. and NAFTOLIN, F. (1986b). Yolk sac failure in embryopathy due to hyperglycemia: ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions. Teratology 33: 73-84.
40. RASHBASS, P. and ELLINGTON, S K L. (1988). Development of rat embryos cultured in serum prepared from rats with streptozotocin-induced diabetes. Teratology 37: 51 -61.
41. REECE, A.E., PINTER, E., LERANTH, C.L., GARCIA-SEGURA, M., SANYAL, M.Y., HOBBINS, J.C , MAHONEY, M.J. and NAFTOLIN, F. (1985). Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemic conditions. Teratology 32: 363-373.
42. SADLER, T.W (1980). Effects of maternal diabetes on early embryogenesis: II. hyperglycemia-induced exencephaly. Teratology 21: 349-356.
43. SADLER, T.W., HUNTER III, E.S., BALKAN, W. and HORTON, W.E. (1988). Effects of maternal diabetes on embryogenesis. Am. J. Perinatal. 5. 319-326.
44. SHEPARD, T.H. and PARK, H.W. (1994). Neural plate microvillus lengthening in rat embryos grown in various concentrations of glucose and further studies of the mechanism Teratology 50: 340-347.
45. SHEPARD, T.H., FANTEL, A.G., MIRKES, P.E , GREENAWAY, J.C., FAUSTMANWATTS, E., CAMPBELL, M. and JUCHAU, M.R. (1983). Teratology testing: 1. Development and status of short-term prescreens 11. Biotransformation of teratogens as studied in whole embryo culture. In Developmental Pharmacology (Eds S MacLeod, A B. Okey and S. Spielberg). Alan R Liss, New York, pp. 147-164.
46. SHEPARD, T.H , PARK, H W. and PASCOE-MASON, J. (1993). Glucose causes lengthening of the microvilli of the neural plate of the rat embryo and produces a helical pattern on their surface. Teratology 48: 65-74.
47. SMITH, D E. and GRIDLEY, T. (1992) Differential screening of a PCR-generated mouse embryo cDNA library. glucose transporters are differentially expressed in early post implantation mouse embryos Development 116: 555-561.
48. SNELL, G D. and STEVENS, L.C. (1966). Early embryology. In The Biology of the Laboratory Mouse, 2nd ed. (Ed E.L. Green). McGraw-Hill, New York-Toronto-Sydney-London, pp. 205-245.
49. TAKAO, Y., AKAZAWA, S. MATSUMOTO, K., TAKINO, H., AKAZAWA, M., TROCINO, R.A., MAEDA, Y., OKUNO, S., KAWASAKI, E., UOTANI, S., YOKOTA, A. and NAGATAKI, S. (1993) Glucose transporter gene expression in rat conceptus during high glucose culture. Diabetologia 36: 696-706.
50. TANIMURA,T A and SHEPARD, T H. (1970) Glucose metabolism by rat embryos in vitro Proc Soc Exp Biol. Med. 135: 51-53.
51. THEILER, K. (1972). The House Mouse Development and Normal Stages from Fertilization to 4 Weeks of Age. Springer-Verlag, Berlin-Heidelberg-New York.
52. TOMLINSON, D.R., CARRINGTON, A.L., DIEMEL, L T., ETTLINGER, C.B., SMITH, W.J. and FERNYHOUGH, P. (1993). Limitations of the polyol hypothesis in the pathobiology of experimental diabetic neuropathy Diabetic Med 10 (Suppl 2): 275-305.
53. WILSON, J G (1977) Current status of teratology - general principles and mechanisms derived from animal studies In Handbook of Teratology (Eds. J.G. Wilson and F.C. Fraser). Plenum Press, New York-London, pp. 47-74.
54. WINEGRAD, A.J. (1987). Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes? Diabetes 36. 396-406.
55. ZUSMAN, I. and ORNOY, A. (1984). Scanning electron microscopic studies of the visceral yolk sac entoderm in early somite rat embryos from streptozotocin diabetic rats and from rats fed a high sucrose diet, in vivo studies. J. Embryol. Exp Morphol. 82 (Suppl.): 79 (Abstr.)