Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies

Protein Science

Volumn 6, Issue 5, 1997, Pages 971-982

  Iversen, L F ^a   Brzozowski, M ^c   Hastrup, S ^b   Hubbard, R ^c   Kastrup, J S ^a   Larsen, I K ^a   Naerum L ^b   Norskov Lauridsen L ^b   Rasmussen, P B ^b   Thim, L ^b   Wiberg, F C ^b   Lundgren, K ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

AMP; AMP analogues; drug design; fructose 1,6 bisphosphatase; IC50; X ray crystallography

Indexed keywords

FRUCTOSE BISPHOSPHATASE;

ALLOSTERISM; ARTICLE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME INHIBITION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 0030970807     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060503     Document Type: Article

References (24)

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