A high-yield synthesis of deoxy-2-fluoroinosine and its incorporation into oligonucleotides

Tetrahedron Letters

Volumn 38, Issue 17, 1997, Pages 2989-2992

  Adib, Abdennaji ^a   Potier, Pierre F ^a   Doronina, Svetlana ^a   Huc, Ivan ^a   Behr, Jean Paul ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINE DERIVATIVE; NUCLEOSIDE DERIVATIVE; ORGANOFLUORINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0030970262     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00540-6     Document Type: Article

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26. Oligonucleotide synthesis was carried out on a Biosearch 8600 DNA Synthesizer on a 1 μmol scale. The standard protocol was modified by increasing the coupling time to 45 sec.
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