메뉴 건너뛰기




Volumn 4, Issue 3, 1997, Pages 252-257

Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10

Author keywords

Gene therapy; IL 1Ra; Interleukin 10; Interleukin 6; sTNF receptor

Indexed keywords

BETA GALACTOSIDASE; IMMUNOMODULATING AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 0030969720     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300387     Document Type: Article
Times cited : (26)

References (34)
  • 1
    • 0028973392 scopus 로고
    • Nomenclature and biologic significance of cytokines involved in inflammation and the host immune response
    • Liles WC, Van Voorhis WC. Nomenclature and biologic significance of cytokines involved in inflammation and the host immune response. J Infect Dis 1995; 172: 1573-1580.
    • (1995) J Infect Dis , vol.172 , pp. 1573-1580
    • Liles, W.C.1    Van Voorhis, W.C.2
  • 2
    • 0028058021 scopus 로고
    • Cytokine elevation in critically ill infants with sepsis and necrotizing enterocolitis
    • Harris MC et al. Cytokine elevation in critically ill infants with sepsis and necrotizing enterocolitis. J Pediatr 1994; 124: 105-111.
    • (1994) J Pediatr , vol.124 , pp. 105-111
    • Harris, M.C.1
  • 3
    • 0026578355 scopus 로고
    • Correlation of plasma cytokine elevations with mortality rate in children with sepsis
    • Sullivan, JS et al. Correlation of plasma cytokine elevations with mortality rate in children with sepsis. J Pediatr 1992; 120: 510-515.
    • (1992) J Pediatr , vol.120 , pp. 510-515
    • Sullivan, J.S.1
  • 4
    • 0027731546 scopus 로고
    • Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
    • Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119: 771-778.
    • (1993) Ann Intern Med , vol.119 , pp. 771-778
    • Casey, L.C.1    Balk, R.A.2    Bone, R.C.3
  • 5
    • 0026575846 scopus 로고
    • Cytokine serum level during severe sepsis in human IL-6 as a marker of severity
    • Damas PD et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1992; 215: 356-362.
    • (1992) Ann Surg , vol.215 , pp. 356-362
    • Damas, P.D.1
  • 6
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1
  • 7
    • 0027408695 scopus 로고
    • Interleukin 10 protects mice from lethal endotoxemia
    • Howard M, Muchamuel T, Andrade S, Menon S. Interleukin 10 protects mice from lethal endotoxemia. J Exp Med 1993 177: 1205-1208.
    • (1993) J Exp Med , vol.177 , pp. 1205-1208
    • Howard, M.1    Muchamuel, T.2    Andrade, S.3    Menon, S.4
  • 8
    • 0027478367 scopus 로고
    • Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
    • Gerard C et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177: 547-550.
    • (1993) J Exp Med , vol.177 , pp. 547-550
    • Gerard, C.1
  • 9
    • 0028299069 scopus 로고
    • Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
    • Willems FA et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007-1009.
    • (1994) Eur J Immunol , vol.24 , pp. 1007-1009
    • Willems, F.A.1
  • 10
    • 0029086123 scopus 로고
    • Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
    • Buelens CF et al. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25: 2668-2672.
    • (1995) Eur J Immunol , vol.25 , pp. 2668-2672
    • Buelens, C.F.1
  • 11
    • 0029100824 scopus 로고
    • Viral interleukin-10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors
    • Suzuki T et al. Viral interleukin-10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J Exp Med 1995; 182: 477-486.
    • (1995) J Exp Med , vol.182 , pp. 477-486
    • Suzuki, T.1
  • 12
    • 0028878703 scopus 로고
    • Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock
    • Gomez-Jimenez JMC et al. Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock. J Infect Dis 1995; 171: 472-475.
    • (1995) J Infect Dis , vol.171 , pp. 472-475
    • Gomez-Jimenez, J.M.C.1
  • 13
    • 0028826247 scopus 로고
    • Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
    • Marchant A et al. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol 1995; 15: 266-273.
    • (1995) J Clin Immunol , vol.15 , pp. 266-273
    • Marchant, A.1
  • 14
    • 0010434379 scopus 로고    scopus 로고
    • The IL-10 response in pediatric sepsis and organ failure
    • Doughty L. The IL-10 response in pediatric sepsis and organ failure. Crit Care Med 1996; 24: A32.
    • (1996) Crit Care Med , vol.24
    • Doughty, L.1
  • 15
    • 0026056197 scopus 로고
    • Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro
    • Dinarello CA, Thompson RC. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 1991; 12: 404-410.
    • (1991) Immunol Today , vol.12 , pp. 404-410
    • Dinarello, C.A.1    Thompson, R.C.2
  • 16
    • 0027384648 scopus 로고
    • LPS-induced sTNF-receptor release in vivo in a murine model
    • Bemelmans MHA, Gouma DJ, Buurman WA. LPS-induced sTNF-receptor release in vivo in a murine model. J Immunol 1993; 151: 5554-5562.
    • (1993) J Immunol , vol.151 , pp. 5554-5562
    • Bemelmans, M.H.A.1    Gouma, D.J.2    Buurman, W.A.3
  • 17
    • 0027198002 scopus 로고
    • Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
    • Mohler KM et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J Immunol 1993, 151: 1548-1561.
    • (1993) J Immunol , vol.151 , pp. 1548-1561
    • Mohler, K.M.1
  • 18
    • 0025713953 scopus 로고
    • Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
    • Hannum CH et al. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 1991; 343: 336-340.
    • (1991) Nature , vol.343 , pp. 336-340
    • Hannum, C.H.1
  • 19
    • 0025943512 scopus 로고
    • Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality
    • Lesslauer WH et al. Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur J Immunol 1991; 21: 2883-2886.
    • (1991) Eur J Immunol , vol.21 , pp. 2883-2886
    • Lesslauer, W.H.1
  • 20
    • 0025787950 scopus 로고
    • Inhibition by interleukin 1 receptor antagonist of in vivo activities of interleukin 1 in mice
    • Mengozzi M, Bertini R, Sironi M, Ghezzi P. Inhibition by interleukin 1 receptor antagonist of in vivo activities of interleukin 1 in mice. Lymphokine Cytokine Res 1991; 10: 405-407.
    • (1991) Lymphokine Cytokine Res , vol.10 , pp. 405-407
    • Mengozzi, M.1    Bertini, R.2    Sironi, M.3    Ghezzi, P.4
  • 21
    • 0025904893 scopus 로고
    • A recombinant human receptor antoagonist to interleukin 1 improves survival after lethal endotoxemia in mice
    • Alexander RH et al. A recombinant human receptor antoagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J Exp Med 1991; 173: 1029-1032.
    • (1991) J Exp Med , vol.173 , pp. 1029-1032
    • Alexander, R.H.1
  • 22
    • 0022411888 scopus 로고
    • Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effects of endotoxin
    • Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effects of endotoxin. Science 1985; 229. 869-871.
    • (1985) Science , vol.229 , pp. 869-871
    • Beutler, B.1    Milsark, I.W.2    Cerami, A.C.3
  • 23
    • 0023491364 scopus 로고
    • Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
    • Tracey KJ et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987; 330: 662-664.
    • (1987) Nature , vol.330 , pp. 662-664
    • Tracey, K.J.1
  • 24
    • 0024822793 scopus 로고
    • Antibodies to cachectin/TNF reduce interleukin-1 and interleukin-6 appearance during lethal bacteremia
    • Fong Y et al. Antibodies to cachectin/TNF reduce interleukin-1 and interleukin-6 appearance during lethal bacteremia. J Exp Med 1989; 170: 1627-1633.
    • (1989) J Exp Med , vol.170 , pp. 1627-1633
    • Fong, Y.1
  • 25
    • 0028786539 scopus 로고
    • Lipopolysaccharide-induced interleukin-10 in mice: Role of endogenous tumor necrosis factor-alpha
    • Barsig JS et al. Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-alpha. Eur J Immunol 1995; 25: 2888-2893.
    • (1995) Eur J Immunol , vol.25 , pp. 2888-2893
    • Barsig, J.S.1
  • 26
    • 0028178254 scopus 로고
    • Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia
    • Marchant A et al. Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia. Eur J Immunol 1994; 24: 1167-1171.
    • (1994) Eur J Immunol , vol.24 , pp. 1167-1171
    • Marchant, A.1
  • 27
    • 0028243036 scopus 로고
    • Prospects for treating arthritis by gene therapy
    • Evans CH, Robbins PD. Prospects for treating arthritis by gene therapy (editorial). J Rheum 1994; 21: 779-782.
    • (1994) J Rheum , vol.21 , pp. 779-782
    • Evans, C.H.1    Robbins, P.D.2
  • 28
    • 0028390749 scopus 로고
    • The interleukin-1 receptor antagonist and its delivery by gene transfer
    • Evans CH, Robbins PD. The interleukin-1 receptor antagonist and its delivery by gene transfer (review). Receptor 1994; 4: 9-15.
    • (1994) Receptor , vol.4 , pp. 9-15
    • Evans, C.H.1    Robbins, P.D.2
  • 29
    • 0027435633 scopus 로고
    • Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
    • Bandara G et al. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764-10768.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10764-10768
    • Bandara, G.1
  • 30
    • 0026644221 scopus 로고
    • Gene transfer to synoviocytes: Prospects for gene treatment of arthritis
    • Bandara G et al. Gene transfer to synoviocytes: prospects for gene treatment of arthritis (review). DNA Cell Biol 1992; 11: 227-231.
    • (1992) DNA Cell Biol , vol.11 , pp. 227-231
    • Bandara, G.1
  • 31
    • 0028066146 scopus 로고
    • Suppression of intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium
    • Hung GL et al. Suppression of intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Therapy 1993; 1: 64-69.
    • (1993) Gene Therapy , vol.1 , pp. 64-69
    • Hung, G.L.1
  • 32
    • 0028850009 scopus 로고
    • Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA
    • Boggs SS et al. Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA. Gene Therapy 1995; 2: 632-638.
    • (1995) Gene Therapy , vol.2 , pp. 632-638
    • Boggs, S.S.1
  • 33
    • 0029559755 scopus 로고
    • Inhibition of transfer of collagen induced arthritis into SCID mice by gene transfer of spleen cells with retroviruses expressing soluble human tumor necrosis factor receptor
    • Chernajovsky Y et al. Inhibition of transfer of collagen induced arthritis into SCID mice by gene transfer of spleen cells with retroviruses expressing soluble human tumor necrosis factor receptor. Gene Therapy 1995; 2: 731-735.
    • (1995) Gene Therapy , vol.2 , pp. 731-735
    • Chernajovsky, Y.1
  • 34
    • 0018183380 scopus 로고
    • Increased lethality after endotoxin in old or leukemic AKR mice
    • Boggs SS, Schwartz GN. Increased lethality after endotoxin in old or leukemic AKR mice. Proc Soc Exp Biol Med 1978, 157: 424-429.
    • (1978) Proc Soc Exp Biol Med , vol.157 , pp. 424-429
    • Boggs, S.S.1    Schwartz, G.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.