Sodium-lithium countertransport, sodium-hydrogen exchange and membrane microviscosity in patients with hyperlipidaemia

Clinical Science

Volumn 92, Issue 3, 1997, Pages 237-246

  Macleod, M J ^a,e   Lee, W K ^a   Devlin, A M ^a   Caslake, M ^b   Anderson, N H ^d   Packard, C J ^b   Dominiczak, M H ^c   Reid, J L ^a   Dominiczak, A F ^a  

^a WESTERN INFIRMARY   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

^c GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e Polwarth Building ^*  (United Kingdom)

Author keywords

Familial hypercholesterolaemia; Hypertriglyceridaemia; Membrane microviscosity; Sodium hydrogen exchange; Sodium lithium countertransport

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; GLUCOSE; INSULIN; LIPID; LITHIUM; PROTON; SODIUM ION;

ARTICLE; BLOOD PRESSURE; BODY MASS; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; ION TRANSPORT; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEMBRANE STRUCTURE; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SODIUM TRANSPORT; VISCOSITY;

EID: 0030969685     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0920237     Document Type: Article

References (53)

1. Godsland IF, Stevenson JC. Insulin resistance: syndrome or tendency? Lancet 1995; 346: 100-3.
2. Reaven GM. The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism 1992; 41: 16-19.
3. Barker DJP, Hales CN, Fall CHD, Osmond C, Clark PMS. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993; 36: 62-7.
4. Phipps K, Barker DJP, Hales CN, Osmond C, Clark PMS. Fetal growth and impaired glucose tolerance in men and women. Diabetologia 1993; 36: 225-8.
5. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science (Washington DC) 1986; 232: 34-47.
6. Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolaemia: mutational analysis of a membrane protein. Ann Rev Genet 1990; 24: 133-70.
7. Galvan A, Santoro D, Natali A, et al. Insulin sensitivity in familial hypercholesterolaemia. Metabolism 1993; 42: 1359-64.
8. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension 1993; 21: 607-17.
9. Canessa M. Red cell sodium-lithium countertransport and cardiovascular risk factors in essential hypertension. Trends Cardiovasc Med 1995; 5: 102-8.
10. + exchange decreases the affinity of sodium sites. Kidney Int 1994; 46: 365-75.
11. Rutherford P. Sodium-lithium countertransport activity is not affected by short-term insulin exposure in vivo or in a physiologic medium in vitro. Metabolism 1993; 42: 1087-9.
12. Carr P, Taub NA, Watts GF, Poston L. Human lymphocyte sodium-hydrogen exchange: the influence of lipids, membrane fluidity, and insulin. Hypertension 1993; 21: 344-52.
13. Canessa M, Adragna N, Solomon HS, Connolly TM, Tosteson DC. Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N Engl J Med 1980; 302: 772-6.
14. Hardman TC, Dubrey SW, Soni S, Lant AF. Relation of sodium-lithium countertransport activity to markers of cardiovascular risk in normotensive subjects. J Hum Hypertens 1995; 9: 589-96.
15. Carr S, Thomas TH, Laker MF, Wilkinson R. Elevated sodium-lithium countertransport: a familial marker of hyperlipidaemia and hypertension? J Hypertens 1990; 8: 139-46.
16. Hasstedt SJ, Wu LL, Ash KO, Kuido H. Williams RR. Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for a major locus inheritance. Am J Hum Genet 1988; 43: 14-22.
17. Turner S, Michels VV. Sodium-lithium countertransport and hypertension in Rochester, Minnesota. Hypertension 1991; 18: 183-90.
18. Hasstedt SJ, Hunt SC, Wu LW, Williams RR. Evidence for multiple genes determining sodium transport. Genet Epidemiol 1994; 11: 553-68.
19. Winocour PH, Thomas TH, Brown L, Wilkinson R. Serum triglyceride and insulin levels are associated with erythrocyte sodium-lithium countertransport activity in normoglycaemic individuals. Clin Chim Acta 1992; 208: 193-203.
20. Corrocher R, Steinmayr M, Ruzznente O, et al. Elevation of red cell Na-Li CT in hyperlipidaemias. Life Sci 1985; 36: 649-55.
21. Hunt S, Williams R, Smith JB, Ash KO. Association of three red blood cell cation transport systems with plasma lipids in Utah subjects. Hypertension 1986; 8: 30-6.
22. Haiem S, Moreau T, Hannaert P, et al. Erythrocyte cation transport systems and plasma lipids in a general male population. J Hypertens 1990; 8: 891-6.
23. Winocour PH, Thomas TH, Brown L, Laker MF, Wilkinson R, Alberti KGGM. Serum triglyceride and insulin levels are associated with erythrocyte sodium-lithium countertransport activity in normoglycaemic individuals. Clin Chim Acta 1992; 208: 193-203.
24. Pinkney J, Denver AE, Foyle WJ, Foster C, Yudkin JS. Insulin resistance and not hyperinsulinaemia determines erythrocyte Na/Li countertransport in non-insulin dependent diabetes mellitus. J Hum Hypertens 1995; 9: 685-6.
25. Doria A, Fioretto P, Avogaro A, et al. Insulin-resistance is associated with high sodium-lithium countertransport in essential hypertension. Am J Physiol 1991; 261: E684-91.
26. Canessa M, Morgan K, Goldszer R, Moore TJ, Spalvins A. Kinetic abnormalities of the red blood cell sodium-proton exchange in hypertensive patients. Hypertension 1991; 17: 340-8.
27. Canessa M, Falkner B, Hulman S. Red blood cell sodium-proton exchange in hypertensive blacks with insulin-resistant glucose disposal. Hypertension 1993; 22: 204-13.
28. Lifton RP, Hunt SC, Williams RR, Pouyssegur J, Lalouel JM. Exclusion of the Na/H antiporter as a candidate gene in human essential hypertension. Hypertension 1991; 17:8-14.
29. Le Quan-Sang KH, Mazeaud M, Astarie C, Duranthon V, Driss F, Devynck MA. Plasma lipids and platelet membrane fluidity in essential hypertension. Thromb Haemostasis 1993; 69: 70-6.
30. Dowd A, Thomas TH, Wilkinson R. Increased human erythrocyte sodium-lithium countertransport in hyperlipidaemic patients may indicate increased membrane lipid fluidity. Eur J Clin Invest 1993; 23: 102-7.
31. Carr SJ, Sikand S, Moore D, Norman RI. Altered membrane microviscosity in essential hypertension: relationship with family history of hypertension and sodium-lithium countertransport activity. J Hypertens 1995; 13: 139-46.
32. Lipid Research Clinics Program. Manual of laboratory operations I: lipid and lipoprotein analysis. Bethesda, MD, U.S.A.: National Institutes of Health, 1975: 75, US Dept of Health, Education and Welfare publication NIH 75-628.
33. Menzel HJ, Utermann O. Apolipoprotein E phenotyping from serum Western blotting. Electrophoresis 1986; 7: 492-5.
34. Rutherford PA, Thomas TH, Carr SJ, Tayfor R, Wilkinson R. Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type I diabetes. Clin Sci 1992; 82: 291-9.
35. Boyum A. A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. Scand J Clin Lab Invest 1968; 21 (Suppl.): 51-76.
36. Roos A, Boron WF. Intracellular pH. Physiol Rev 1981; 61: 296-434.
37. McLaren Y, Kreutz R, Lindpaintner K, et al. Membrane microviscosity does not correlate with blood pressure: a cosegregation study. J Hypertens 1993; 11: 25-30.
38. Bland JM, Altman DG. The use of transformation when comparing two means. Br Med J 1996; 312: 1153.
39. Cumming AM, Robertson AR. Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin Genet 1984; 25: 310-13.
40. Thomas TH, Rutherford PA, West IC, Wilkinson R. Sulphydryl group control of sodium-lithium countertransport kinetics: a membrane protein control abnormality in essential hypertension. Eur J Clin Invest 1995; 25: 235-40.
41. Rutherford PA, Thomas TH, Laker MF, Wilkinson R. Plasma lipids affect maximum velocity not sodium affinity of human sodium-lithium countertransport: distinction from essential hypertension. Eur J Clin Invest 1992; 22: 719-24.
42. Engelmann B, Duhm J, Schonthier UM, Streich S. Relations of sodium-lithium countertransport kinetics to plasma and red cell membrane phospholipids in hyperlipidemia. Atherosclerosis 1993; 99: 151-63.
43. Strazzullo P, Cappuccio FP, Trevisan M, et al. The relationship of erythrocyte sodium-lithium countertransport to blood pressure and metabolic abnormalities in a sample of untreated middle-aged male workers. J Hypertens 1993; 11: 815-22.
44. Mangili R, Zerbini G, Barlassina C, Cusi D, Pozza G. Sodium-lithium countertransport and triglycerides in diabetic nephropathy. Kidney Int 1993; 44: 127-33.
45. Canessa M, Zerbini G, Barlassina C, Cusi D, Pozza G. Sodium activation kinetics of red blood cell Na/Li countertransport in diabetes: methodology and controversy. J Am Soc Nephrol 1992; 3: S41-9.
46. Levy R. Lithium-sodium countertransport and lithium leak in erythrocytes are differentially affected by membrane enrichment with cholesteryl hemisuccinate. Biochim Biophys Acta 1986; 854: 325-8.
47. Carr S, Thomas TH, Laker MF, Wilkinson R. Lipid lowering therapy leads to a reduction in sodium-lithium countertransport activity. Atherosclerosis 1991; 87: 103-8.
48. Poli De Figueiredo CE, Ng LL, Davis JE, Luzio-Cazana FJ, Ellory JC, Hendry BM. Modulation of Na/H antiporter activity in human lymphoblasts by altered membrane cholesterol. Am J Physiol 1991; 261: C1138-42.
49. Le Quan-Sang KH, Montenay-Garestier T, Devynck MA. Alterations of platelet membrane microviscosity in essential hypertension. Clin Sci 1991; 80: 205-11.
50. Muriana F, Garcia-Donas MA, Villar J, Ruiz-Gutierrez V. Distribution of erythrocyte membrane cholesterol in human essential hypertension. J Hypertens 1994; 12: 1383-6.
51. Zaidi KF, Yudkin JS. Characteristics of the sodium/hydrogen exchange in non-insulin-dependent diabetic patients with microalbuminuria and hypertension. Clin Sci 1996; 90: 13-19.
52. Rutherford PA, Thomas TH, Wilkinson R. Sodium-lithium countertransport and sodium exchange - are they mediated by the same transporter. Lithium 1994; 5: 1-10.
53. Delva P, Pastori C, Degan M, et al. Erythrocyte Na-H exchanger kinetics and Na-Li countertransport activity in essential hypertensive patients. Eur J Clin Invest 1996; 26: 64-70.