Expression and localization of thrombomodulin in preneoplastic bronchial lesions and in lung cancer

Virchows Archiv

Volumn 430, Issue 3, 1997, Pages 209-212

  Tolnay, Edina ^a,b   Wiethege, Thorsten ^b   Müller, Klaus Michael ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Epithelial differentiation; Keratinisation; Lung cancer; Preneoplasia; Squamous cell carcinoma; Thrombomodulin

Indexed keywords

ANTICOAGULANT PROTEIN; GLYCOPROTEIN; THROMBOMODULIN;

ARTICLE; BRONCHUS CANCER; BRONCHUS MUCOSA; CELL DIFFERENTIATION; DYSPLASIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; BRONCHIAL DISEASES; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; PRECANCEROUS CONDITIONS; STAINING AND LABELING; THROMBOMODULIN; TISSUE DISTRIBUTION;

EID: 0030969332     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01324803     Document Type: Article

References (23)

1. Boffa MC, Karnochkine M, Berard M (1991) Plasma thrombomodulin as a marker for endothelium damage. Nouv Rev Fr Hematol 33: 529-530
2. Collins CL, Ordonez NG, Schafer R, Cook CD, Xie SS, Granger J, Hsu P-L, Fink L, Hsu S-M (1992) Thrombomodulin-expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am J Pathol 141: 827-833
3. Conway KM, Nowakowski B, Stiner-Mosonyi M (1992) Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation. Blood 80: 1254-1263
4. Cordell JL, Falini B, Erber WN (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP) complexes. J Histochem Cytochem 32: 219-229
5. Dittman WA, Majerus PW (1990) Structure and function of thrombomodulin: a natural anticoagulant. Blood 75: 329-336
6. Esmon CT, Owen WG (1981) Identification of an endothelial cell cofactor for thrombin-catalyzed activation for protein C. Proc Natl Acad Sci USA 78: 2249-2252
7. Gazdar AF, Linnoila RI, Kurita Y, Oie HK, Mulshine JL, Clark JC, Whitsett JA (1990) Peripherial airway cell differentiation in human lung cancer cell lines. Cancer Res 50: 5481-5487
8. Imada S, Yamaguchi H, Nagumo M, Katayanagi S, Iwasaki H, Imada M (1990) Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays. Dev Biol 140: 113-122
9. Lager DJ, Callaghan EJ, Worth SF, Raife TJ, Lentz RL (1995) Cellular localisation of thrombomodulin in human epithelium and squamous malignancies. Am J Path 146: 933-943
10. Lindahl AK, Boffa M-C, Abildgaard U (1993) Increased plasma thrombomodulin in cancer patients. Thromb Haemost 69: 112-114
11. Maruyama I, Bell CE, Majerus PW (1985) Thrombomodulin is found im endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 101:363-371
12. McCahren SS, Diggs J, Weinberg JB, Dittman WA (1991) Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 78: 3128-3132
13. Nierodzik ML, Plotkin A, Kajumo F, Karpatkin S (1991) Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. J Clin Invest 87: 229-236
14. Ogura M, Ito T, Maruyama I, Takamatsu J, Yamamoto S, Ogawa K, Nagura H, Saito H (1990) Localisation and biosynthesis of functional thrombomodulin in human megakaryocytes and a human megakaryoblastic cell lines (MEG-01). Thromb Haemost 64: 297-301
15. Ornstein DL, Zacharski LR, Menedi VA, Kisiel W, Kudryk B, Hunt, J, Rousseau S, Stump DC (1991) Coexisting macrophage-associated fibrin formation and tumor cell urokinase in squamous cell and adenocarcinoma of the lung tissues. Cancer 68: 1061-1067
16. Petersen TE (1988) The amino-terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins. FEBS Lett 231: 51-53
17. Raife TJ, Lager DJ, Madison KC, Piette WW, Howard EJ, Sturm MT, Chen Y, Lentz SR (1994) Thrombomodulin expression by human keratinocytes. J Clin Invest 93: 1846-1851
18. Suehiro T, Shimada M, Matsumata T, Taketomi A, Yamamoto K, Sugimachi K (1995) Thrombomodulin inhibits intrahepatic spread in human hepatocellular carcinoma. Hepatology 21: 1285-1290
19. Suzuki K, Nishioka J, Hayashi T, Kosaka Y (1988) Functionally active thrombomodulin is present in human platelets. J Biochem (Tokyo) 104: 628-632
20. Takano S, Kimura S, Ohdama S, Aoki N (1990) Plasma thrombomodulin in health and disease. Blood 76: 2024-2029
21. Tezuka Y, Yonezawa S, Maruyama I, Matsushita Y, Shimizu T, Obama H, Sagara M, Shirao K, Kusano C, Natsugoe S, Yoshinaka H, Masamichi B, Fukumoto T, Aikou T, Sato E (1995) Expression of thrombomodulin in esophageal squamous cell carcinoma and its relationship to lymph node metastasis. Cancer Res 55: 4196-4200
22. Yonezawa S, Maruyama I, Sakae K, Igata A, Majerus PW, Sato E (1987) Thrombomodulin as a marker for vascular tumors. Am J Clin Pathol 88: 405-411
23. World Health Organization (1981) International histological classification of tumors. Number 1. Histological typing of lung tumors, 2nd edn. WHO, Geneva