Improved reactivity of hepatitis C virus core protein epitopes in a conformational antigen-presenting system

Clinical and Diagnostic Laboratory Immunology

Volumn 4, Issue 2, 1997, Pages 117-121

  Buratti, E ^a   Di Michele, M ^a   Song, P ^a   Monti Bragadin, C ^a   Scodeller, E A ^a   Baralle, F E ^a,b   Tisminetzky, S G ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SYNTHETIC PEPTIDE;

ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 0030969274     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.4.2.117-121.1997     Document Type: Article

References (33)

1. Blum, P., M. Velugan, N. Lin, and A. Matin. 1992. DnaK-mediated alterations in human growth hormone protein inclusion bodies. Bio/Technology 10:301-304.
2. Buratti, E., S. G. Tisminetzky, E. S. Scodeller, and F. E. Baralle. 1996. Conformational display of two neutralizing epitopes of HIV-1 gp41 on the Flock House virus capsid protein. J. Immunol. Methods 197:7-18.
3. Cerino, A., P. Boender, N. La Monica, C. Rosa, W. Habets, and M. U. Mondelli. 1993. A human monoclonal antibody specific for the N-terminus of the hepatitis C virus nucleocapsid protein. J. Immunol. 151:7005-7015.
4. Chien, D. Y., Q.-L. Choo, A. Tabrizi, C. Kuo, J. McFarland, K. Berger, C. Lee, J. R. Shuster, T. Nguyen, D. L. Moyer, M. Tong, S. Furuta, M. Omata, G. Tegtmeier, H. Alter, E. Schiff, L. Jeffers, M. Houghton, and G. Kuo. 1992. Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease. Proc. Natl. Acad. Sci. USA 89:10011-10015.
5. Ching, W.-M., C. Wychowski, M. J. Beach, H. Wang, C. L. Davies, M. Carl, D. W. Bradley, H. J. Alter, F. M. Feinstone, and W.-K. Shih. 1992. Interaction of immune sera with synthetic peptides corresponding to the structural protein region of hepatitis C virus. Proc. Natl. Acad. Sci. USA 89:3190-3194.
6. Choo, Q.-L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B hepatitis genome. Science 244:359-362.
7. Choo, Q.-L., K. H. Richman, J. H. Han, K. Berger, C. Lee, C. Dong, C. Gallegos, D. Coit, A. Medina-Selby, P. J. Barr, A. J. Weiner, D. W. Bradley, G. Kuo, and M. Houghton. 1991. Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA 88:2451-2455.
8. Claeys, H., A. Volkaerts, H. De Beenhouwer, and C. Vermylen. 1992. Association of HCV carrier state with the occurrence of HCV-core antibodies. J. Med. Virol. 36:259-264.
9. Ferroni, P., G. Mascolo, M. Zaninetti, D. Colzani, F. Pregliasco, M. Pirisi, F. Barbone, and V. Gasparini. 1993. Identification of four epitopes in hepatitis C virus core protein. J. Clin. Microbiol. 31:1586-1591.
10. Goeser, T., H. M. Muller, J. Ye, E. Pfaff, and M. Theilmann. 1994. Characterization of antigenic determinants in the core antigen of the hepatitis C virus. Virology 205:462-469.
11. Houghton, M., A. Weiner, G. Kuo, and Q.-L. Choo. 1991. Molecular biology of hepatitis C viruses: implications for diagnosis, development, and control of viral disease. Hepatology 14:381-388.
12. Katayama, T., T. Mazda, S. Kikuchi, S. Harada, Y. Matsuura, J. Chiba, H. Ohba, I. Saito, and T. Miyamura. 1992. Improved serodiagnosis of non-A, non-B hepatitis by an assay detecting antibody to hepatitis C virus core antigen. Hepatology 15:391-394.
13. Kato, N., M. Hijikata, Y. Ootsuyama, M. Nagakawa, S. Ohkoshi, T. Sugimura, and K. Shimotohno. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A non-B hepatitis. Proc. Natl. Acad. Sci. USA 87:9524-9528.
14. Khanna, A., and R. Ray. 1995. Hepatitis C virus core protein: synthesis, affinity purification and immunoreactivity with infected human sera. Gene 153:185-189.
15. Kuo, G., Q.-L. Choo, H. J. Alter, G. L. Gitnik, A. G. Redeker, R. H. Purcell, T. Miyamura, J. L. Dienstag, M. J. Alter, C. E. Stevens, G. E. Tegtmeier, F. Bonino, M. Colombo, W. S. Lee, C. Kuo, K. Berger, J. R. Shuster, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. An assay for circulating antibodies to a major etiologic virus of human non-A non-B hepatitis. Science 244:362-364.
16. Miyamura, T., I. Saito, T. Katayama, S. Kikuchi, A. Tateda, M. Houghton, Q.-L. Choo, and G. Kuo. 1990. Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for post-transfusional hepatitis. Proc. Natl. Acad. Sci. USA 87:983-987.
17. Mohammed, K., and A. Esen. 1989. A blocking agent and a blocking step are not needed in ELISA, immunostaining dot-blots and Western blots. J. Immunol. Methods 117:141-145.
18. Moore, J. P. 1993. The reactivities of HIV-1+ human sera with solid-phase V3 loop peptides can be poor predictors of their reactivities with V3 loops on native gp120 molecules. AIDS Res. Hum. Retroviruses 9:209-217.
19. Moore, J. P., Y. Cao, A. J. Conley, R. Wyatt, J. Robinson, M. K. Gorny, S. Zolla-Pazner, D. D. Ho, and R. A. Koup. 1994. Studies with monoclonal antibodies to the V3 region of HIV-1 gp-120 reveal limitations to the utility of solid-phase peptide binding assays. J. Acquired Immunodefic. Syndr. 7:332-339.
20. Nagayama, R., K. Miyake, F. Tsuda, and H. Okamoto. 1994. IgM antibody to a hepatitis C virus core peptide (CP14) for monitoring activity of liver disease in patients with acute or chronic hepatitis C. J. Med. Virol. 42:311-317.
21. Nasoff, M. S., S. L. Zebedee, G. Inchauspe', and A. M. Prince. 1991. Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proc. Natl. Acad. Sci. USA 88:5462-5466.
22. Nishizono, A., M. Hiraga, K. Mifune, H. Terao, T. Fujioka, M. Nasu, T. Goto, J. Misumi, M. Moriyama, and Y. Arakawa. 1993. Correlation of serum antibody titres against hepatitis C virus core protein with clinical features by Western blot (immunoblot) analysis using a recombinant vaccinia virus expressing system. J. Clin. Microbiol. 31:1173-1178.
23. Ohkoshi, S., M. Watanabe, K. Kuwana, H. Tawaraya, T. Kamimura, and H. Asakura. 1993. Clinical evaluation of the antibody against core protein of hepatitis C virus. Gastroenterol. Jpn. 28:80-83.
24. Saito, M., A. Hasegawa, T. Kashiwakuma, M. Kohara, M. Sugi, K. Miki, T. Yamamoto, H. Mod, Y. Ohta, E. Tanaka, K. Kiyosawa, S. Furuta, M. Wakashima, S. Tanaka, and H. Hattori. 1992. Performance of an enzyme linked immunosorbent assay system for antibodies to hepatitis C virus with two new antigens (c11/c7). Clin. Chem. 38:2434-2439.
25. Sallberg, M., P. Pumpen, Z. X. Zhang, P. Lundholm, I. Gusars, U. Ruden, B. Wahren, and L. O. Magnious. 1994. Locations of antibody binding sites within conserved regions of the hepatitis C virus core protein. J. Med. Virol. 43:62-68.
26. Schutten, M., J. P. M. Langedijk, A. C. Andeweg, R. C. Huisman, R. H. Meloen, and A. D. M. E. Osterhaus. 1995. Characterization of V3 domain specific neutralizing human mAb that preferentially recognizes non-syncytiurn-inducing HIV-1 strains. J. Gen. Virol. 76:1665-1673.
27. Scodeller, E. A., S. G. Tisminetzky, F. Porro, M. Schiappacassi, A. De Rossi, L. Chiecco-Bianchi, and F. E. Baralle. 1995. A new epitope presenting system displays a HIV-1 V3 loop sequence and induces neutralizing antibodies. Vaccine 13:1233-1240.
28. Siemoneit, K., M. da Silva Cardoso, A. Wopl, S. Epple, H. Wintersinger, K. Koerner, and B. Kubanek. 1994. Isotype-specific immune response to a single hepatitis C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR. Ann. Hematol. 69:129-133.
29. Takamizawa, A., C. Mori, I. Fuke, S. Manabe, S. Murakami, J. Fujita, E. Onishi, T. Andoh, I. Yoshida, and H. Oyakama. 1991. Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 65:1105-1113.
30. Tanaka, E., K. Kiyosawa, Y. Nakatsuji, Y. Inoue, T. Miyamura, J. Chiba, and S. Furuta. 1993. Clinical significance of antibodies to non-structural and core proteins of hepatitis C virus in posttransfusion hepatitis patients during long-term follow-up. J. Med. Virol. 39:318-324.
31. Tisminetzky, S. G., E. A. Scodeller, P. Evangelisti, Y. Chen, M. Schiappacassi, F. Porro, F. Bizik, T. Zacchi, G. Lunazzi, S. Miertus, and F. E. Baralle. 1994. Immunoreactivity of chimeric proteins carrying the HIV-1 epitope IGPGRAF. Correlation between predicted conformation and antigenicity. FEBS Lett. 353:1-4.
32. Waumans, L., H. Claeys, H. Verhaert, W. Mertens, and C. Vermylen. 1992. Hepatitis C virus confirmation in blood donor screening. Vox Sang. 927:1-5.
33. Yeh, C. T, C. M. Han, S. Y. Lo, J. H. Ou, K. D. Fan, I. S. Sheen, C. M. Chu, and Y. F. Liaw. 1994. Early determination of anti-HCc antibody in acute hepatitis C virus (HCV) by Western blot (immunoblot) using a recombinant HCV core protein fragment. J. Clin. Microbiol. 32:2235-2241.