Insulin-Like Growth Factor-I and Its Binding Protein-3 in Serum: Are They Good Screening Properties for the Diagnosis of Growth Hormone Deficiency?

Clinical Chemistry and Laboratory Medicine

Volumn 35, Issue 5, 1997, Pages 379-386

  Koch, Andreas ^a   Dörr, Helmut Günther ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ARTICLE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; NEUROSECRETION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHORT STATURE;

ADOLESCENT; BODY HEIGHT; CHILD; CHILD, PRESCHOOL; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; NEUROSECRETORY SYSTEMS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; VARIATION (GENETICS);

EID: 0030969179     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm.1997.35.5.379     Document Type: Article

References (48)

1. Blum WF. Insulin-like growth factors and their binding proteins. In: Ranke MB, editor. Functional endocrinologic diagnostics in children and adolescents. Mannheim: J&J Verlag, 1993: 102-117.
2. Tassoni P, Cacciari E, Cau M, Colli C, Tosi M, Zucchini S, et al. Variability of growth hormone response to pharmacological and sleep tests performed twice in short children. J Clin Endocrinol Metab 1990: 71: 230-234.
3. Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor-I and its structural homology with proinsulin. J Biol Chem 1978: 253: 2769-76.
4. Furlanetto RW, Underwood LE, Van Wyk JJ, D'Ercole AJ. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977: 60: 648-657.
5. Zapf J, Kiefer M, Merryweather J, Masiarz F, Bauer D, Born W, et al. Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. J Biol Chem 1990: 265: 4892-8.
6. Roberts CT, Brown AL, Graham DE, Seelig S, Berry S, Gabbay KH, et al. Growth hormone regulates the abundance of insulin-like growth factor-I RNA in adult rat liver. J Biol Chem 1986: 261: 10025-8.
7. Schwander JC, Hauri C, Hapf J, Froesch ER. Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology 1983: 113: 297-305.
8. Emler CA, Schalch DS. Nutritionally-induced changes in hepatic insulin-like growth factor-I (IGF-I) gene expression in rats. Endocrinology 1987: 120: 832-834.
9. Hintz RL, Suskind R, Amatayakul K, Thanangkul O, Olson R. Plasma somatomedin and growth hormone values in children with protein-calorie malnutrition. J Pediatr 1978: 92: 153-156.
10. Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocrine Reviews 1994: 16: 80-101.
11. Rosenfeld RG, Wilson DM, Lee PDK, Hintz RL. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr 1986: 109: 428-433.
12. Dean HJ, Kellet JG, Bala RM, Guyda HJ, Bhaumick B, Posner BI, et al. The effect of growth hormone treatment on somatomedin levels in growth hormone-deficient children. J Clin Endocrinol Metab 1982: 55: 1167-73.
13. Bacter RC, Cowell CT. Diurnal rhythm of growth hormoneindependent binding protein for the insulin-like growth factors in human plasma. J Clin Endocrinol Metab 1987: 65: 432-440.
14. Guier HP, Zapf J, Schmid C, Froesch ER. Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol Copenh 1989: 121: 753-758.
15. Baxter RC, Marin JL. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling. Proc Natl Acad Sei USA 1989: 86: 6898-902.
16. Martin JL, Baxter RC. Insulin-like growth factor binding protein from human plasma: purification and characterization. J Biol Chem 1987: 261: 8754-60.
17. Blum WF, Albertson-Wikland K, Rosberg S, Ranke MB. Serum levels of insulin-like growth factor (IGF) and IGF-binding protein 3 (IGFBP-3) reflect spontaneous growth hormone secretion. J Clin Endocrinol Metab 1993: 76: 1610-6.
18. Albiston AL, Herington AC. Tissue distribution and regulation of the insulin-like growth factor (IGFP)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: comparison with the IGF-I mRNA expression. Endocrinology 1992: 130: 497-502.
19. Ranke MB, Blum WF, Frisch H. The acid-stable subunit of insulin-like growth factor binding protein (IGFBP-3) in disorders of growth. In: Drop SLS, Hintz RL, editors. Insulin-like growth factor binding proteins. Amsterdam: Excerpta Medica, 1989: 103-113.
20. Blum WF, Ranke MB, Kietzmann K, Tönshoff B, Mehls O. Growth hormone resistance and inhibition of somatomedin activity by excess of the insulin-like growth factor binding protein in uremia. Pediatr Nephrol 1991: 5: 539-544.
21. Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. J Clin Invest 1986: 78: 1504-12.
22. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein and its use for diagnosis of the GH deficiency. J Clin Endocrinol Metab 1990: 70: 1292-8.
23. Jorgensen JOL, Blum WF, Moller N, Ranke MB, Christiansen JS. Circadian patterns of the serum insulin-like growth factors (IGF) II and IGF binding protein 3 in growth hormone deficient patients and age- and sex-matched normal subjects. Acat Endocrinol Copenh 1990: 123: 257-262.
24. Zapf J, Walter H, Froesch ER. Radioummunological determination of insulin-like growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 1981: 68: 1321-30.
25. Minuto JP, Underwood LE, Grimaldi P, Furlanetto RW, Van Wyk JJ, Giordano G. Decreased serum somatomedin C concentration during sleep: temporal relationship to the nocturnal surges of growth hormone and prolactin. J Clin Endocrinol Metab 1981: 52: 399-403.
26. Prader A, Largo RH, Molinari L, Issler C. Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development. Helv Paediatr Acta 1989: 52 Suppl: 1-125.
27. Hauffa BP. Klinische und laboranalytische Meβwerte. In: Stolecke H, editor. Endokrinologie des Kindes- und Jugendalters. Berlin: Springer-Verlag, 1992: 784-787.
28. Merriam GR, Wächter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol 1982: 243: 310-318.
29. D'Ercole AJ, Underwood LE, Van-Wyk JJ. Serum somatomedin-C in hypopituitarism and in other disorders of growth. J Pediatr 1977: 90: 375-381.
30. Ranke MB, Blum WF, Bierich JR. Clinical relevance of serum measurements of insulin-like growth factors and somatomedin binding proteins. Acta Pediatr Scand 1988: 347 Suppl: 114-126.
31. Zapf J, Rinderknecht E, Humbel RE, Froesch ER. Nonsupressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implications. Metab ClinExp 1978: 27: 1803-23.
32. Copeland KC, Underwood LE, Van Wyk JJ. Induction of immunoreactive somatomedin-C in human serum by growth hormone: dose response relationships and effect on Chromatographie profiles. J Clin Endocrinol Metab 1980: 50: 690-697.
33. Rosenfeld RG, Kemp SF, Hintz RL. Constancy of somatomedin response to growth hormon treatment of hypopituitary dwarfism and lack of correlation with growth rate. J Clin Endocrinol Metab 1981: 53: 611-617.
34. Kao PC, Metheny AP, Lang CA. Insulin-like growth factor-I comparisons in healthy twin children. J Clin Endocrinol Metab 1994: 78: 310-312.
35. Blum WF. Die Bedeutung von IGF-I, IGF-II und IGFBP-3 für die Diagnostik des Wachstumshormonmangels. In: Ranke MB, Stolecke H, editors. Diagnostik des Wachstumshormonmangels. Ankum: Verlag Dokument und Bild, 1994: 197-233.
36. Cianfarani S, Boemi S, Spagnoli A, Cappa M, Argiro G, Vaccaro F, et al. Is IGF binding protein-3 assessment helpful for the diagnosis of growth hormone deficiency? Clin Endocrinol 1995: 43: 43-47.
37. Adan L, Souberbielle JC, Brauner R. Diagnostic markers of permanent idiopathic growth hormone deficiency. J Clin Endocrinol Metab 1994: 78: 353-358.
38. Smith WJ, Nam TJ, Underwood LE, Bubsy WH, Celnicker A, Clemmons DR. Use of insulin-like growth factor binding protein 2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab 1993: 77: 1264-99.
39. Binoux M, Gourmelen M, Girard F. Serum levels of insulinlike growth factor (IGF) and IGF-binding protein in constitutionally short children and adolescents. Acta Endocrinol Copenh 1986: 113: 145-152.
40. Cacciari E, Cicognani A, Pirazzoli P, Tassoni P, Salardi S, Capelli M, et al. Differences in somatomedin-C between shortnormal subjects and those of normal height. J Pediatr 1985: 106: 891-894.
41. Rudman D, Kutner MH, Chawla RK. The short child with subnormal plasma somatomedin C. Pediatr Res 1985: 19: 975-980.
42. Cacciari EC, Tassoni P, Cicognani A, Pirazzoli P, Salardi Balsamo, SA, et al. Value and limits of pharmacological and physiological tests to diagnose growth hormone (GH) deficiency and predict therapy response: first and second retesting during replacement therapy of patients defined as GH deficient. J Clin Endocrinol Metab 1994: 79: 1663-9.
43. Martha PM Jr, Gorman KM, Blizzard RM, Rogol AD, Veldhuis JD. Endogenous growth hormone secretion and clearance rates in normal boys as determined by deconvolution analysis: relationship to age, pubertal status, and body mass. J Clin Endocrinol Metab 1992: 74: 336-344.
44. Rocchiccioli P, Pienkowski C, Tauber MT, Uboldi F, Enjaume C. Association of pharmacological test and study of 24-hour growth hormone secretion in the investigation of growth retardation in children: analysis of 257 cases. Horm Res 1991: 35: 70-75.
45. Kaplan SL, Abrams CAL, Bell JJ, Conte FA, Grumbach MM. Growth and growth hormone. I. Changes in serum level of growth hormone following hypoglycemia in 134 children with growth retardation. Pediatr Res 1968: 2: 43-63.
46. Rosenfeld RG, Albertson-Wikland K, Cassorla F, Frasier SD, Hasegawa Y, Hintz RL, et al. The diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab 1995: 80: 1532-40.
47. Donaldson DL, Hollowell JG, Pan F, Gifford RA, Moore WV. Growth hormone secretory profiles: variation on consecutive nights. J Pediatr 1989: 115: 51-56.
48. Donaldson DL, Pan F, Hollowell JG, Stevenson JL, Gifford RA, Moore WV. Reliability of stimulated and spontaneous growth hormone (GH) levels for identifying the child with low GH secretion. J Clin Endocrinol Metab 1991: 72: 647-652.