Rapid elimination of mouse/human chimeric monoclonal antibodies in nude mice

Cancer Immunology Immunotherapy

Volumn 44, Issue 2, 1997, Pages 103-111

  Van Gog, Frank B ^a   Brakenhoff, Ruud H ^a   Snow, Gordon B ^a   Van Dongen, Guus A M S ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

biodistribution; chimeric antibodies; squamous cell carcinoma; tumour targeting; tumour bearing nude mice

Indexed keywords

CANCER ANTIBODY; CHIMERIC ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOGLOBULIN G; IODINE RADIOISOTOPES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECOMBINANT FUSION PROTEINS; TISSUE DISTRIBUTION;

EID: 0030969059     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050362     Document Type: Article

References (22)

1. Brakenhoff RH, Van Gog FB, Looney JE, Van Walsum M, Snow GB, Van Dongen GAMS (1995) Construction and characterization of the chimeric monoclonal antibody E48 for therapy of head and neck cancer. Cancer Immunol Immunother 40:351
2. 2 fragment and whole IgG2a in human glioma xenografts. Cancer Res 48:5701
3. 99mTc-labelled monoclonal antibody E48 IgG or F(ab′)2. J Nucl Med 35:775
4. De Bree R, Roos JC, Quak JJ, Den Hollander W, Snow GB, Van Dongen GAMS (1994) Clinical screening of monoclonal antibodies 323/A3, cSF-25, and K928 for suitability of targeting tumors in the upper-aerodigestive and respiratory tract. Nucl Med Commun 15:613
5. 99mTc-labeled monoclonal antibody U36 and its biodistribution in patients with head and neck cancer. Clin Cancer Res 1:591
6. Eccles SA, Purvies HP, Styles JM, Hobbs SM, Dean CJ (1989) Pharmacokinetic studies of radiolabelled rat monoclonal antibody recognising syngeneic sarcoma antigens. Cancer Immunol Immunother 30:5
7. Göttlinger HG, Funke I, Johnson JP, Gokel JM, Riethmüller G (1986) The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies. Int J Cancer 38:47
8. Haisma HJ, Hilgers J, Zurawski VR (1986) Iodination of monoclonal antibodies for diagnosis and therapy using a convenient one vial method. J Nucl Med 27:1890
9. Khazaeli MB, Conry R, LoBuglio AF (1994) Human immune response to monoclonal antibodies. J Immunother 15:42
10. Kobayashi H, Sakahara H, Saga T, Hosono M, Shirato M, Kanda H, Ishibashi K, Watanabe T, Endo K, Ishiwata I, Konishi J (1993) A human/mouse chimeric monoclonal antibody against CA125 for radioimmunoimaging of ovarian cancer. Cancer Immunol Immunother 37:143
11. Koprowski H, Steplewski Z, Mitchell K, Herlyn M, Herlyn D, Fuhrer P (1979) Colorectal carcinoma antigens detected by hybridoma antibodies. Somat Cell Genet 5:957
12. Mink JG, Radl J, Van den Berg P, Haaijman JJ, Van Zwieten MJ, Benner R (1980) Serum immunoglobulins in nude mice and their heterozygous littermates during ageing. Immunology 40:539
13. Miotti S, Canevari S, MJnard D, Mezzanzanica D, Porro G, Pupa SM, Regazzoni M, Tagliabue E, Colnaghi MI (1987) Characterisation of human ovarian carcinoma associated antigens defined by novel monoclonal antibodies with tumor restricted specificity. Int J Cancer 39:297
14. Quak JJ, Van Dongen GAMS, Balm AJM, Brakkee JPG, Scheper RJ, Snow GB, Meijer CJLM (1990) A 22-kDa surface antigen detected by monoclonal antibody E48 is exclusively expressed in stratified squamous and transitional epithelia. Am J Pathol 136:191
15. Quak JJ, Schrijvers AHGJ, Brakkee JGP, Davis HD, Scheper RJ, Balm AJM, Meijer CJLM, Snow GB, Van Dongen GAMS (1992) Expression and characterization of two differentiation antigens in stratified squamous epithelia and carcinomas. Int J Cancer 50:507
16. Rogers GT, Pedley RB, Boden J, Harwood PJ, Bagshawe KD (1986) Effect of dose escalation of a monoclonal anti-CEA IgG on tumour localisation and tissue distribution in nude mice xenografted with human colon carcinoma. Cancer Immunol Immunother 23:107
17. Schrijvers AHGJ, Quak JJ, Uyterlinde AM, Van Walsum M, Meijer CJLM, Snow GB, Van Dongen GAMS (1993) mAb U36, a novel monoclonal antibody successful in immunotargeting of squamous cell carcinoma of the head and neck. Cancer Res 53:3524
18. Sharkey RM, Natale A, Goldenberg DM, Mattes MJ (1991) Rapid blood clearance of immunoglobulin G2a and immunoglobulin G2b in nude mice. Cancer Res 51:3102
19. Stein R, Goldenberg DM, Mattes MJ (1991) Normal tissue reactivity of four anti-tumor monoclonal antibodies of clinical interest. Int J Cancer 47:163
20. Steplewski Z, Sun LK, Shearman CW, Ghrayeb J, Donnadona P, Koprowski H (1991) Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity. Proc Natl Acad Sci USA 85:4852
21. Takahashi H, Wilson B, Ozturk M, Motte P, Straus W, Isselbacher KJ, Wands JR (1988) In vivo localization of human colon adenocarcinoma by monoclonal antibody binding to highly expressed cell surface antigen. Cancer Res 48:1460
22. Wessels BW (1990) Current status of animal radioimmunotherapy. Cancer Res 50:970s