Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy

American Journal of Kidney Diseases

Volumn 29, Issue 6, 1997, Pages 912-918

  Pedagogos, Eugenia ^a   Hewitson, Timothy ^a   Fraser, Ian ^a   Nicholls, Kathy ^a   Becker, Gavin ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Arteriolar sclerosis; Collagen; Diabetes; Interstitium; Myofibroblast

Indexed keywords

ADULT; AGED; ARTERIOLOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; DIABETIC NEPHROPATHY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY BIOPSY; KIDNEY ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MYOFIBROBLAST; PATHOGENESIS;

EID: 0030969043     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(97)90466-2     Document Type: Article

References (38)

1. Fine LG, Norman JT: Renal growth responses to acute and chronic injury: Routes to therapeutic intervention. J Am Soc Nephrol 3:206-224, 1992 (suppl 1)
2. Horlyck A, Gunderson HJG, Osterby R: The cortical distribution pattern of diabetic glomerulopathy. Diabetologia 29:146-150, 1986
3. Bader R, Bader H, Grund KE, Markensen-Haen S, Christ H, Bohle A: Structure and function of the kidney in diabetic glomerulosclerosis: Correlations between morphologic and functional parameters. Pathol Res Pract 167:204-216, 1980
4. Harris HD, Steffes MW, Bilous RW, Sutherland DER, Mauer SM: Global glomerular sclerosis and glomerular arteriolar hyalinosis in insulin dependent diabetes. Kidney Int 40:107-114, 1991
5. Mechanisms of progression, the role of vascular injury/ sclerosis, in EI Nahas AM, Mallick NP, Anderson S (eds): Prevention of Progressive Chronic Renal Failure, vol 1. Oxford, United Kingdom, Oxford University, 1993, pp 98-116
6. Bohle A, Gise HV, MacKensen-Haen S, Stark-Jakob B: The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Klin Wochenschr 59:1043-1051, 1981
7. Gabbiani G, Ryan GB, Majno G: Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549-550, 1971
8. Sappino A, Schürch W, Gabbiani G: Differentiation repertoire of flbroblastic cells: Expression of cytoskeletal proteins as a marker of phenotypic modulations. Lab Invest 63:144-161, 1990
9. Hewitson TD, Becker GJ: Interstitial myofibroblasts in IgA glomerulonephritis. Am J Nephrol 15:111-117, 1995
10. Vangelista A, Frasca GM, Severi B, Bonomini V: The role of myofibroblasts in renal interstitial fibrosis and their relationship with fibronectin and type IV collagen. Contrib Nephrol 70:135-141, 1989
11. Alpers CE, Hudkins KL, Floege J, Johnson RJ: Human renal cortical interstitial cells with some features of smooth muscle cells participate in tublointerstitial and crescentic glomerular injury. J Am Soc Nephrol 5:201-210, 1996
12. Diamond JR, Van Goor H, Ding G, Engelmyer: Myofibroblasts in experimental hydronephrosis. Am J Pathol 146:121-129, 1995
13. Hsu SM, Raine L, Fanger H: Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981
14. Skalli O, Rporaz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G: A monoclonal antibody against α-smooth muscle actin: A new probe for smooth muscle differentiation. J Cell Biol 103:2787-2796, 1986
15. Sehested M, Hou-Jensen K: F8 related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch (Pathol Anat) 391:217-225, 1981
16. Baak J, Oort J: Practical morphometry, in Baak J, Oort J (eds): A Manual of Morphometry in Diagnostic Pathology. Berlin, Germany, Springer, 1983
17. McWhinnie DL, Thompson JF, Taylor HM, Chapman JR, Bolton EM, Carter NP, Wood RFM, Morris PJ: Morphometric analysis of cellular infiltration assessed by monoclonal antibody labelling in sequential renal allograft biopsies. Transplantation 42:352-358, 1986
18. Frøkjaer Thomsen O, Andersen A, Christiansen JS, Deckert T: Renal changes in long term type 1 insulin-dependent diabetic patients with and without clinical nephropathy: A light microscopic, morphometric study of autopsy material. Diabetologia 26:361-365, 1984
19. Mauer S, Stelles M, Elles E, Sutherland D, Brown D, Goetz F: Structural functional relationships in diabetic nephropathy. J Clin Invest 74:1143-1155, 1984
20. Lane PH, Steffes MW, Fioretto P, Mauer SM: Renal interstitial expansion in insulin dependent diabetes mellitus. Kidney Int 43:661-669, 1993
21. Risdon RA, Sloper JC, de Wardener HE: Relationship between renal function and histological changes found in renal biopsy specimens from patients with persistent glomerular nephritis. Lancet 1:363-366, 1968
22. Bell ET: Renal vascular disease in diabetes mellitus. Diabetes 2:376-389, 1953
23. Coodate F, Daouds AS, Florentin R, Lee KT, Gittelsohn A: Chemicoanatomic studies of arteriolosclerosis and thrombosis in diabetes. Exp Mol Pathol 1:353-363, 1962
24. Garcia MJ, McNamara PM, Gordon T, Kannel WB: Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes 23:105-111, 1974
25. Sato T, Yopshinaga K: Sclerosis of the renal artery and hyalinization of the renal glomeruli in diabetics. Tohoku J Exp Med 153:327-330, 1978
26. Fine LG, Norman JT: Renal growth responses to acute and chronic injury: Routes to therapeutic intervention. J Am Soc Nephrol 3:206-211, 1992 (suppl 1)
27. El Nahas AM: Pathways to renal fibrosis. Exp Nephrol 3:71-75, 1995
28. Ong ACM, Jowett TP, Firth JD, Burton S, Kitamura M, Fine LG: Human tubular-derived endothelin in paracrine regulation of renal interstitial fibroblast function. Exp Nephrol 2:1345, 1994
29. Hewitson TD, Darby IA, Bisucci T, Jones CL, Becker GJ: Evolution of interstitial fibrosis in experimental renal infection and scarring. J Am Soc Nephrol 7:1756, 1996
30. Kovacs EJ: Fibrogenic cytokines: The role of immune mediators in the development of scar tissue. Immunol Today 12:17-23, 1991
31. Stiles CD, Capone GT, Scher CD, Antoniades HN, Van Wyke JJ, Pledger WJ: Dual control of cell growth by somatomedins and PDGF. Proc Natl Acad Sci 76:1279-1283, 1979
32. Tang WW, Hill DC, Tarpely JE, Van GY, Qi M: PDGF-B is associated with myofibroblast formation in α-GBM Ab tubulointerstitial nephritis: Exogenous PDGF-BB induced tubulointerstitial fibrosis. J Am Soc Nephrol 6:913, 1995
33. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103-111, 1993
34. Hewitson TD, Wu HL, Becker GJ: Interstitial myofibroblasts in experimental renal infection and scarring. Am J Nephrol 15:411-417, 1995
35. Sharma AK, Mauer SM, Kim V, Michael AF: Interstitial fibrosis in obstructive nephropathy. Kidney Int 44:774-788, 1993
36. Wiggins R, Goyal M, Merritt S, Killen PD: Vascular adventitial cell expression of collagen I messenger ribonucleic acid in anti-glomerular basement membrane antibody induced crescentic nephritis in the rabbit: A cellular source for interstitial collagen synthesis in inflammatory renal disease. Lab Invest 68:557-565, 1993
37. Edelman ER, Nugent MA, Smith LT, Karnovsky MJ: Basic fibroblast growth factor enhances the coupling of intimai hyperplasia and proliferation of vasa vasorum in injured rat arteries. J Clin Invest 89:465-473, 1992
38. Goumenos D, Brown CB, Shortland J, El Nahas AM: Myofibroblasts, prediction of progression of IgA nephropathy. Nephrol Dial Transplant 9:1418-1425, 1994