Patterns of meiotic variability of the (CAG)(n) repeat in the Huntington disease gene

Genetic Counseling

Volumn 8, Issue 2, 1997, Pages 77-81

  Lucotte, G ^a,c   Gerard N ^a   Aouizerate A ^a   Loirat, F ^b   Hazout, S ^b  

^a REIMS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL MAISON BLANCHE   (France)

Author keywords

CAG repeat; Huntington's disease (HD); Meiotic instability

Indexed keywords

ARTICLE; FRANCE; HUMAN; HUNTINGTON CHOREA; MAJOR CLINICAL STUDY; MEIOSIS; PARENT; PROGENY; TRINUCLEOTIDE REPEAT;

ADULT; DNA; FEMALE; GENETIC MARKERS; GENETIC SCREENING; HUMANS; HUNTINGTON DISEASE; MALE; MEIOSIS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; TRINUCLEOTIDE REPEATS; VARIATION (GENETICS);

EID: 0030968169     PISSN: 10158146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. ANDREW S.E., GOLDBERG Y.P., KREMER B., TELENIUS H., THEILMANN J., ADAM S., STARR E., SQUITIERI F., LIN B., KALCHMAN M.A., GRAHAM R.K. and HAYDEN M.R. : The relationship between trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet., 1993, 5, 398-403.
2. DUYAO M., AMBROSE C., MYERS R., NOVOLLETO A., PERSICHETTI F., FRONTALI M., FOLSTEIN S., ROSS C., FRANZ M., ABBOTT M., GRAY J., CONNALY P., YOUNG A., PENNEY J., HOLLINGSWORTH Z., SHOULSON I., LAZZARINI A., FALEK A., KOROSHETZ W., SAX D., BIRD E., VONSATELL J., BONILLA E., ALVIR J., BICKHAM CONDE J., CHA J.H., DURE L., GOMEZ F., RAMOS M., SANCHEZ-RAMOS J., SNODGRASS S., DE YOUNG M., WEXLER N., MOSCOWITZ C., PENCHASZADEH G., MAC FARLANE H., ANDERSON M., JENKINS B., SRINIDHI J., BARNES G. GUSELLA J. and MAC DONALD M. : Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet., 1993, 5, 387-392.
3. KREMER B., GOLDBERG P., ANDREW S.A., THEILMAN J., TELENIUS H., ZEISLER J., SQUITIERI F., LIN B., BASSETS A., ALMQVIST E., BIRD T.D. and HAYDEN M.R. : A worldwide study of the Huntington's disease mutation. New Engl . J. of Med., 1994, 330, 1401-1406.
4. KREMER B., ALMQVIST E., THEILMANN J., SPENCE N., TELENIUS H., GOLDBERG Y.P. and HAYDEN M.R. : Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington's disease chromosomes. Am. J. Hum. Genet., 1995, 57, 343-350.
5. LEGIUS E., CUPPENS H., DIERICK H., VAN ZANDT K., DOM R., FRYNS J.P., EVERS-KIEBOOMS G., DECRUYE-NAERE M., DEMYTTENAERE K., MARYNEN P. and CASSIMAN J.J. : Limited expansion of the (CAG)n repeat of the Huntington gene : a premutation? Eur. J. Hum. Genet., 1994, 1, 44-50.
6. LUCOTTE G., AOUIZERATE A., LOREILLE O., GERARD N., TURPIN J.C. and THE FRENCH HD RESEARCH GROUP : Trinucleotide repeat elongation in the huntingtin gene in Huntington's disease patients from 85 French families. Gen. Couns., 1994, 5, 321-328.
7. n repeat, in Huntington's disease. Hum. Genet., 1995, 95, 231-232.
8. NØRREMØLLE A., SØRENSEN S.A., FENGER K. and HASHOLT L. : Correlation between magnitude of CAG repeat length alterations and length of the paternal repeat in paternally inherited Huntington's disease. Clin. Genet, 1995, 47, 113-117.
9. NOVELLETO A., PERSICHETTI F., SABBADINI G., MANDICH P., BELLONE E., AJMAR F., PERGOLA M., DEL SENNO L., MACDONALD M., GUSELLA J.F. and FRONTALI M. : Analysis of the trinucleotide repeat expansion in Italian families affected with Huntington's disease. Hum. Mol. Genet., 1994, 3, 93-98.
10. n repeats causing Huntington's disease. Hum. Mol. Genet., 1993, 2, 637.
11. SNELL R.G., MACMILLAN J.C., CHEADLE J.P., FENTON I., LAZAROU L.P., DAVIES P., MACDONALD M., GUSELLA J., HARPER PS. and SHAW D.J. : Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nature Genet., 1993, 5, 393-397.
12. n repeat length is the sex of the affected parent. Hum. Mol. Genet., 1993, 2, 1535-1540.
13. THE HUNTINGTON'S DISEASE COLLABORATIVE GROUP : A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 1993, 72, 971-983.
14. TROTTIER Y., BIANCALANA V. and MANDEL J.L. : Instability of CAG repeats in Huntington's disease : relation to parental transmission and age of onset. J. Med. Genet., 1994, 31, 377-382.
15. n repeat in Huntington's disease gene. Hum. Mol. Genet., 1993, 2, 2063-2067.