Human lymphotoxin mutein lacks hypotensive activity but has higher in vivo antitumor activity than lymphotoxin or tumor necrosis factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 7, 1997, Pages 3324-3329

  Taniyama, Mitsue ^a   Morita, Toshimi ^a   Yamagishi, Yasuhiro ^a   Kato, Akihisa ^a   Bando, Chinami ^a   Okawa, Noriyuki ^a   Kaji, Akira ^b  

^a TSUMURA AND CO   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LYMPHOTOXIN; MUTEIN 2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; GENE DELETION; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MAXIMUM PERMISSIBLE DOSE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXIN ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; HYPOTENSION; LYMPHOTOXIN-ALPHA; MALE; MICE; MICE, NUDE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0030967655     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.7.3324     Document Type: Article

References (54)

1. Van Ostade, X., Tavernier, J. & Fiers, W. (1994) Protein Eng. 7, 5-22.
2. Creasey, A. A., Doyle, L. V., Reynolds, M. T., Jung, T., Lin, L. S. & Vitt, C. R. (1987) Cancer Res. 47, 145-149.
3. Soma, G., Kitahara, N., Tsuji, Y., Kato, M., Oshima, H., Gatanaga, T., Inagawa, H., Noguchi, K., Tanabe, Y. & Mizuno, D. (1987) Biochem. Biophys. Res. Commun. 148, 629-635.
4. Nakamura, S., Kato, A., Masegi, T., Fukuoka, M., Kitai, K., Ogawa, H., Ichikawa, Y., Maeda, M., Watanabe, N., Kohgo, Y. & Niitsu, Y. (1991) Int. J. Cancer 48, 744-748.
5. Miyata, K., Kato, M., Shikama, H., Nishimura, K., Sakae, N., Kawagoe, K., Nishikawa, T., Kuroda, K., Yamaguchi, K., Aoyama, Y., Mitsuishi, Y. & Yamada, N. (1992) Clin. Exp. Metastasis 10, 267-272.
6. Seow, H.-F., Goh, C. R., Krishnan, L. & Porter, A. G. (1989) Bio/Technology 7, 363-368.
7. Aggarwal, B. B., Henzel, W. J., Moffat, B., Kohr, W. J. & Harkins, R. N. (1985) J. Biol. Chem. 260, 2334-2344.
8. Gray, P. W., Aggarwal, B. B., Benton, C. V., Bringman, T. S., Henzel, W. J., Jarrett, J. A., Leung, D. W., Moffat, B., Ng, P., Svedersky, L. P., Palladino, M. A. & Nedwin, G. E. (1984) Nature (London) 312, 721-724.
9. Saks, S. & Rosenblum, M. (1991) in Tumor Necrosis Factors: Structure, Function, and Mechanism of Action (Marcel Dekker, New York), pp. 567-587.
10. Spriggs, D. R. & Yates, S. W. (1992) in Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine (Raven, New York), pp. 383-406.
11. Turner, C. R., Esser, K. M., Wheeldon, E. B., Slivjak, M. & Smith, E. F., III (1989) Circ. Shock 28, 369-384.
12. Nakatsuji, K., Ku, Y., Fujitani, B. & Ito, T. (1990) Arzneim.-forsch./Drug Res. 40, 218-225.
13. Weinberg, J. R., Wright, D. J. M. & Guz, A. (1988) Clin. Science (London) 75, 251-255.
14. Takahashi, K., Ando, K., Ono, A., Shimosawa, T., Ogata, E. & Fujita, T. (1992) Life Sci. 50, 1437-1444.
15. Maniatis, T., Fritsch, E. F. & Sambrook, J. (1989) in Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
16. Mosmann, T. (1983) J. Immunological Methods 65, 55-63.
17. Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N. & Williamson, B. (1975) Proc. Natl. Acad. Sci. USA 72, 3666-3670.
18. Talmadge, J. E., Key, M. E. & Hart, I. R. (1981) Cancer Res. 41, 1271-1280.
19. Goldin, A., Venditti, J. M., MacDonald, J. S., Muggia, F. M., Henney, J.E. & Devita, V. T., Jr. (1981) Eur. J. Cancer 17, 129-142.
20. Foley, G. E., Drolet, B. P., McCarthy, R. E., Goulet, K. A., Dokos, J. M. & Filler, D. A. (1960) Cancer Res. 20, 930-939.
21. Corbett, T. H., Griswold, D. P., Jr., Roberts, B. J., Peckham, J. C. & Schabel, F. M., Jr. (1977) Cancer 40, 2660-2680.
22. Puck, T. T., Marcus, P. I. & Cieciura, S. J. (1956) J. Exp. Med. 103, 273-284.
23. Eagle, H. (1955) Proc. Soc. Exp. Biol. Med. 89, 362-364.
24. Chou, T.-C. (1976) J. Theor. Biol. 59, 253-276.
25. Shimizu, M., Uchiya, N., Inoue, A. & Udaka, K. (1985) The Clinical Report 19, 7-8.
26. Matsuyama, N., Okawa, N., Tsukii, Y., Endo, T. & Kaji, A. (1992) FEBS Lett. 302, 141-144.
27. Ito, R., Matsumoto, H., Uchida, K., Kubo, T., Tsukii, Y., Endo, T. & Kaji, A. (1991) Biochim. Biophys. Acta. 1096, 245-252.
28. Morishige, H., Ohkuma, T. & Kaji, A. (1993) Biochim. Biophys. Acta. 1151, 59-68.
29. Kreil, E. A., Greene, E., Fitzgibbon, C., Robinson, D. R. & Zapol, W. M. (1989) Circ. Res. 65, 502-514.
30. Ulich, T. R., del Castillo, J., Keys, M. & Granger, G. A. (1987) Am. J. Pathol. 128, 5-12.
31. Ishitsuka, H., Miwa, M., Takemoto, K., Fukuoka, K., Itoga, A. & Maruyama, H. B. (1980) Gann 71, 112-123.
32. Fletcher, J. R., Collins, J. N., Graves, E. D., Luterman, A., Williams, M. D., Izenberg, S. D. & Rodning, C. B. (1993) Ann. Surg. 217, 668-675.
33. Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., III, Zentella, A., Albert, J. D., Shires, G. T. & Cerami, A. (1986) Science 234, 470-474.
34. Locksley, R. M., Heinzel, F. P., Shepard, H. M., Agosti, J., Eessalu, T. E., Aggarwal, B. B. & Harlan, J. M. (1987) J. Immunol. 139, 1891-1895.
35. Seregina, T. M., Mekshenkov, M. I., Turetskaya, R. L. & Nedospasov, S. A. (1989) Mol. Immunol. 26, 339-342.
36. Buck, C., Digel, W., Schoniger, W., Stefanic, M., Raghavachar, A., Heimpel, H. & Porzsolt, F. (1990) Leukemia 4, 431-434.
37. De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P. R., Fick, A., Mariathasan, S., Smith, S. C., Carlson, R., Shornick, L. P., Strauss, J.-S., Russell, J. H., Karr, R. & Chaplin, D. D. (1994) Science 264, 703-707.
38. Hohmann, H.-P., Remy, R., Poschl, B. & van Loon, A. P. G. M. (1990) J. Biol. Chem. 265, 15183-15188.
39. Schoenfeld, H.-J., Poeschil, B., Frey, J. R., Loetscher, H., Hunziker, W., Lustig, A. & Zulauf, M. (1991) J. Biol. Chem. 266, 3863-3869.
40. Schall, T. J., Lewis, M., Koller, K. J., Lee, A., Rice, G. C., Wong, G. H. W., Gatanaga, T., Granger, G. A., Lentz, R., Raab, H., Kohr, W. J. & Goeddel, D. V. (1990) Cell 61, 361-370.
41. Aggarwal, B. B., Eessalu, T. E. & Hass, P. E. (1985) Nature (London) 318, 665-667.
42. Browning, J. L., Ngam-ek, A., Lawton, P., DeMatinis, J., Tizard, R., Chow, E. P., Hession, C., O'Brine-Greco, B., Foley. S. F. & Ware, C. F. (1993) Cell 72, 847-856.
43. Crowe, P. D., VanArsdale, T. L., Walter, B. N., Ware, C. F., Hession, C., Ehrenfels, B., Browning, J. L., Din, W. S., Goodwin, R. G. & Smith, C. A. (1994) Science 264, 707-710.
44. Browning, J. L., Dougas, I., Ngam-ek, A., Bourdon, P. R., Ehrenfels, B. N., Miatkowski, K., Zafari, M., Yampaglia, A. M., Lawton, P., Meier, W., Benjamin, C. P. & Hession, C. (1995) J. Immunol. 154, 33-46.
45. Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B. & Goeddel, D. V. (1984) Nature (London) 312, 724-729.
46. Banner, D. W., D'Arcy, A., Janes, W., Gentz, R., Schoenfeld, H.-J., Broger, C., Loetscher, H. & Lesslauer, W. (1993) Cell 73, 431-445.
47. Wakabayashi, T., Asada, M., Nagasu, T., Iijima, A., Hasegawa, Y., Shikata, Y. & Kitoh, K. (1990) J. Biol. Chem. 265, 7604-7609.
48. Kolls, J., Peppel, K., Silva, M. & Beutler, B. (1994) Proc. Natl. Acad. Sci. USA 91, 215-219.
49. Sherry, B. A., Gelin, J., Fong, Y., Marano, M., Wei, H., Cerami, A., Lowry, S. F., Lundholm, K. G. & Moldawer, L. L. (1989) FASEB J. 3, 1956-1962.
50. Havell, E. A. (1989) J. Immunol. 143, 2894-2899.
51. Lieberman, A. P., Pitha, P. M., Shin, H. S. & Shin, M. L. (1989) Proc. Natl. Acad. Sci. USA 86, 6348-6352.
52. Rothstein, J. L. & Schreiber, H. (1988) Proc. Natl. Acad. Sci. USA 85, 607-611.
53. Wong, G. H. W. & Goeddel, D. V. (1986) Nature (London) 323, 819-822.
54. Asher, A., Mule, J. J., Reichert, C. M., Shiloni, E. & Rosenberg, S. A. (1987) J. Immunol. 138., 963-974.