Acute effects of celiprolol on muscle blood flow and insulin sensitivity: Studies using [15O]-water, [18F]-fluorodeoxyglucose and positron emission tomography

European Journal of Clinical Pharmacology

Volumn 52, Issue 1, 1997, Pages 19-26

  Malminiemi, K ^a,b   Laine, H ^c   Knuuti, M J ^d   Ruotsalainen, U ^d   Oikonen, V ^d   Haaparanta, M ^e   Nuutila, P ^c  

^a Oy Leiras Finland Ab   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TURKU PET CENTRE   (Finland)

^e ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

celiprolol; euglycaemic clamp; fluorodeoxyglucose; insulin sensitivity; muscle blood flow; positron emission tomography

Indexed keywords

CELIPROLOL; FLUORODEOXYGLUCOSE F 18; PLACEBO; WATER O 15;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; GLUCOSE TRANSPORT; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MUSCLE BLOOD FLOW; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VASCULAR RESISTANCE;

ADRENERGIC BETA-ANTAGONISTS; ADULT; CELIPROLOL; CROSS-OVER STUDIES; DEOXYGLUCOSE; DOUBLE-BLIND METHOD; DRUG EVALUATION; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OXYGEN RADIOISOTOPES; RECEPTORS, ADRENERGIC, BETA-1; REGIONAL BLOOD FLOW; TOMOGRAPHY, EMISSION-COMPUTED; VASODILATOR AGENTS; WATER;

EID: 0030966655     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050243     Document Type: Article

References (44)

1. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico Ma, Oleggini M, Gradiadei L, Brandi L, Bevilacqua (1987) Insulin resistance in essential hypertension. N Engl J Med 317: 350-357
2. Yki-Järvinen H, Consoli A, Nurjhan N, Young AA. Gerich JE (1989) Mechanism for underestimation of isotopically determined glucose disposal. Diabetes 38: 744-751
3. Nuutila P, Knuuti J, Ruotsalainen U, Koivisto VA, Eronen E, Teräs M, Bergman J, Haaparanta M, Voipio-Pulkki L-M, Viikari J, Rönnemaa T, Wegelius U, Yki-Järvinen H (1993) Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes. Am J Physiol 264: E756-762
4. Baron AD (1994) Hemodynamic actions of insulin. Am J Physiol 267: E187-202
5. Raitakari M, Knuuti MJ, Ruotsalainen U, Laine H, Mäkelä P, Teräs M, Sipilä H, Niskanen T, Raitakari OT, Härkönen Ä, Wegelius U, Yki-Järvinen H, Nuutila P (1995) Insulin increases blood volume in human skeletal muscle. Studies using 15-O carbon monoxide and positron emission tomography. Am J Physiol 269: E1000-1005
6. Laakso M, Edelman SV, Brechtel G, Baron AD (1990) Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 85: 1844-1852
7. Pollare T, Lithell H, Selinus I, Berne C (1988) Application of prazosin is associated with an increase in insulin sensitivity in obese patients with hypertension. Diabetologia 31: 415-420
8. Milne RJ, Buckley MMT (1991) Celiprolol - An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in cardiovascular disease. Drugs 41: 941-969
9. Dhein S, Titzer S, Wallstein M, Muller A, Gerwin R, Panzner B, Klaus W (1992) Celiprolol exerts microvascular dilatation by activation of beta-2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 346: 27-31
10. Tung LH, Jackman G, Campbell B, Louis S, lakovidis D, Louis WJ (1993) Partial agonist activity of celiprolol. J Cardiovasc Pharmacol 21: 484-488
11. Pittner H (1983) Pharmacodynamic effects of celiprolol, a cardioselective beta-receptor blocker. Arzneim Forsch 33: 13-25
12. Bonelli J, Magometchnigg D, Hitzenberger G, Kaik G (1978) Haemodynamic characterisation of a new beta-receptor blocking agent, celiprolol, at rest and during ergometer exercise, compared with propranolol. Wien Klin Wschr 90: 350-354
13. Trimarco B, Lembo G, De Luca N, Ricciardelli B, Rosiello G, Volpe M, Orofino G, Condorelli M (1987) Effects of celiprolol on systemic and forearm circulation in hypertensive patients. A double-blind cross-over study versus metoprolol. J Clin Pharmacol 27: 593-600
14. Bohlen LM, de Courten M, Hafezi F, Shaw S, Riesen W, Weidmann P (1994) Insulin sensitivity and atrial natriuretic factor during beta-receptor modulation with celiprolol in normal subjects. Cardiovasc Pharmacol 23: 877-883
15. Kritz H, Najemnik C, Irsigler K (1983) Beta-receptor blockade and diabetes mellitus: effect of celiprolol on blood sugar level and insulin in type I and type II diabetes. Arzneim Forsch 33: 72-76
16. Fogari R, Lazzari P, Zoppi A, Tettamanti F, Malamani G, Boari L (1990) The effects of celiprolol in the short-term treatment of hypertensive patients with type 2 diabetes. Curr Ther Res 47: 879-888
17. Malminiemi K, Lahtela J, Huupponen R (1995) Effects of celiprolol on insulin sensitivity and glucose tolerance in dyslipidemic hypertension. Int J Clin Pharmacol Ther 32: 156-163
18. Depairon M, Depresseux J-C, Petermans J, Zicot M (1991) Assessment of flow and oxygen delivery to the lower extremity in arterial insuffiency: a PET-scan study comparison with other methods. Angiology 42: 788-795
19. Nuutila P, Koivisto VA, Knuuti J, Ruotsalainen U, Teräs M, Haaparanta M, Bergman J, Solin O, Voipio-Pulkki L-M, Wegelius U, Yki-Järvinen H (1992) The glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 89: 1767-1774
20. 2O and positron emission tomography. J Nucl Med 38
21. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237: E214-223
22. Koivisto VA, Yki-Järvinen H, Puhakainen I, Virkamäki A, Kolaczynski J, DeFronzo R (1990) No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man. Diabetologia 33: 168-173
23. Malminiemi K (1995) Association between serum lipids, glucose tolerance and insulin sensitivity during 12 months of celiprolol treatment. Cardiovasc Drugs Ther 9: 295-304
24. Crouzel C, Clark J, Brihaye C, Långström B, Lemaire C, Meyer G, Nebeling B, Stone-Elander S (1993) Radiochemistry automation for PET. In: Stöcklin G, Pike V (eds) Radiopharmaceuticals for positron emission tomography. Kluwer Academic publishers, Dordrecht, pp 54-56
25. 18F]-fluoro-2-deoxy-D-glucose usine aminopolyether supported nucleophilic substitution. J Nucl Med 27: 235-238
26. Spinks TJ, Jones T, Gilardi MC, Heatrec JD (1988) Physical performance of the latest generation of commercial positron scanner. IEEE Trans Nucl Sci 35: 721-725
27. Sipilä H, Heselius S-J, Saarni H, Ahlfors T (1985) A compact low-voltage ionization chamber for monitoring positron- and photon-emitters in flowing gases. In: Nuclear instruments and methods in physics research. Nucl Instr Meth Phys Res A238: 542-545
28. Kety S (1951) The theory and application of the exchange of inert gas at the lungs and tissue. Pharmacol Rev 3: 1-24
29. 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab 6: 536-545
30. 18F)fluoro-2-deoxy-D-glucose studies. J Nucl Med 32: 733-738
31. Patlak CS, Blasberg RG (1985) Graphic evaluation of blood-to-brain transfer constants from multiple-time uptake data generalizations. J Cereb Blood Flow Metabol 5: 584-590
32. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron A (1994) Insulin-mediated skeletal muscle vasodilatation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94: 1172-1179
33. Creager MA, Liang C-S, Coffman JD (1985) Beta-adrenergic mediated vasodilator response to insulin in the human forearm. J Pharmacol Exp Ther 235: 709-714
34. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL (1991) Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans. J Clin Invest 87: 2246-2252
35. Pittner H (1985) Intrinsic sympathomimetic action and its special features as demonstrated by the beta-1-receptor blocker celiprolol. Wien Klin Wochenschr 162 (Suppl): 1-21
36. Jamerson KA, Smith SD, Amerena JV, Grant E, Julius S (1994) Vasoconstriction with norepinephrine causes less forearm insulin resistance than a reflex sympathetic vasocontriction. Hypertension 23: 1006-1011
37. Connolly CC, Steiner KE, Stevenson RW, et al (1991) Regulation of glucose metabolism by norepinephrine in conscious dogs. Am J Physiol 261: E764-772
38. Webber J, Macdonald IA (1993) Metabolic actions of catecholamines in man. Baillieres Clin Endocrin Metab 7: 393-413
39. Nuutila P, Knuuti MJ, Heinonen O, Ruotsalainen U, Teräs M, Yki-Järvinen H, Haaparanta M, Bergman J, VoipioPulkki L-M, Wegelius U, Koivisto VA (1994) Opposite alterations in insulin stimulated glucose uptake in heart and skeletal muscle after physical training. J Clin Invest 93: 2267-2274
40. Nuutila P, Mäki M, Laine H, Knuuti MJ, Ruotsalainen U, Teräs M, Luotolahti M, Bergman J, Solin O, Voipio-Pulkki L-M, Koivisto V, Yki-Järvinen H (1996) Insulin action on heart and skeletal muscle glucose uptake in essential hypertension. J Clin Invest (in press)
41. Busst CM, Bush A (1989) Comparison of the cardiovascular and pulmonary effects of oral celiprolol, propranolol and placebo in normal volunteers. Br J Clin Pharmacol 27: 405-410
42. Hartmann C, Frolich M, Krauss D. Spahn-Langguth H, Knauf H, Mutschler E (1990) Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function. Eur J Clin Pharmacol 39: 573-576
43. Kuo SM, Whitby BR, Artursson P, Ziemniak JA (1994) The contribution of intestinal secretion to the dose-dependent absorption of celiprolol. Pharm Res 11: 648-653
44. Lamontagne D, Pohl U, Busse R (1992) Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res 70: 123-130