Expression of CD44V2 in transitional cell carcinoma of the urinary bladder and in urine

Urological Research

Volumn 25, Issue 3, 1997, Pages 187-192

  Muller M ^a   Heicappell, R ^a   Habermann, F ^a   Kaufmann, M ^b   Steiner, U ^a   Miller, K ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alternative splicing; Bladder cancer; CD44V2; Diagnostic marker; Immunohistochemistry; Urothelium

Indexed keywords

HERMES ANTIGEN;

ARTICLE; BLADDER CARCINOMA; CLINICAL ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA; URINALYSIS;

ANTIBODY SPECIFICITY; ANTIGENS, CD44; CARCINOMA, TRANSITIONAL CELL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; TUMOR MARKERS, BIOLOGICAL; URETERAL NEOPLASMS; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 0030965983     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00941981     Document Type: Article

References (23)

1. Abbasi AM, Chester KA, Talbot IC, Macpherson AS. Boxer G, Forbes A, Malcolm ADB, Begent RHJ (1993) CD44 is associated with proliferation in normal and neoplastic human colorectal epithelial cells. Eur J Cancer 29A:1995
2. Borgya A, Woodman A, Sugiyama M, Donié F, Kopetzki E, Matsumara Y, Tarin D (1995) Isolation and characterisation of antibodies which specially recognise the peptide encoded by exon 7 (v2) of the human CD 44 gene. Clin Mol Pathology 48:241
3. Can̈nistra SA, Abu-Jawdeh G, Niloff J, Strobel T. Swanson L, Anderesen J, Ottensmeier C (1995) CD44 variant expression is a common feature of epithelial ovarian cancer: lack of association with standard prognostic factors. J Clin Oncol 13:1912
4. East JA, Hart IR (1993) CD44 and its role in tumour progression and metastasis. Eur J Cancer 29A:1921
5. Flanagan BF, Dalchau R, Allen AK, Daar AS, Fabre JW (1989) Chemical composition and tissue distribution of the human CD44w44 glycoprotein. Immunology 67:167
6. Fox SB, Fawcett J, Jackson DG, Collins I, Gatter KC, Harris AL, Gearing A, Simmons DL (1994) Normal human tissues, in addition to some tumors, express multiple different isoforms. Cancer Res 54:4539
7. Friedrichs K, Franke F, Lisboa BW, Kügler G, Gille I, Terpe HJ, Hölzel F, Maass H, Gunthert U (1995) CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res 55:5424
8. Günthert U, Hofmann M, Rudy W, Reber S, Zöller M, Haußmann I, Matzku S, Wenzel A, Ponta H, Herlich P (1991) A new variant glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13
9. Guo YJ, Liu G, Wang X, Jin D, Wu M, Ma J, Sy MS (1994) Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer. Cancer Res 54:422
10. Heider KH, Dämmrich J, Skroch-Angel P, Müller-Hermelink HK, Vollmers HP, Herrlich P, Ponta H (1993) Differential expression of CD44 splice variants in intestinal and diffuse-type human gastric carcinomas and normal gastric mucosa. Cancer Res 53:4197
11. Hong RL, Pu YS, Hsieh TS, Chu JS, Lee WJ (1995) Expressions of E-cadherin and exon V6-containing isoforms of CD44 and their prognostic values in human transitional cell carcinoma. J Urol 153:2025
12. Jackson DG, Screaton GR, Bell MV, Bell JI (1993) CD44 and cancer. Lancet 341:252
13. Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P (1995) CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet 345:615
14. Li H, Hamou MF, de Tribolet N, Jaufeerally R, Hofmann M, Diserens AC, van Meir EG (1993) Variant CD44 adhesion molecules are expressed in human brain metastasis but not in glioblastomas. Cancer Res 53:5345
15. Matsumara Y, Tarin D (1992) Significance of CD44 gene products for cancer diagnosis and disease evaluation. Lancet 340:1053
16. Matsumara Y, Hanburry D, Smith J, Tarin D (1994) Non invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells. BMJ 308:619
17. Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin N Am 3:13
18. Penno MB, August JT, Baylin SB, Mabry M, Linnoila RI, Lee VS, Croteau D, Yang XL, Rosada C (1994) Expression of CD44 in human lung tumors. Cancer Res 54:138
19. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI (1992) Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci 89:12160
20. Southgate J, Trejdosiewicz LK, Smith B, Selby PJ (1995) Patterns of splice variant CD44 expressions by normal human urothelium in situ and in vitro and by bladder carcinoma cell lines. Int J Cancer 62:449
21. Tarin D, Matsumara Y (1994) Recent advances in the study of tumour invasion and metastasis. J Clin Pathol 47:385
22. Tarin D, Matsumara Y (1993) Deranged activity of the CD44 gene and other loci as biomarkers for progressions to metastatic malignancy. J Cell Biochem 17:173
23. Wielanga VJM, Heider KH, Offerhaus GJA, Adolf GR, van den Berg FM, Ponta H, Herrlich P, Pals ST (1993) Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res 53:4754