Plasma levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers

Biological Psychiatry

Volumn 41, Issue 6, 1997, Pages 756-757

  Lawlor, Brian A ^a   Radcliffe, Jeanne ^b   Martinez, Rick ^b   Sunderland, Trey ^b   Murphy, Dennis L ^b  

^a ST JAMES S HOSPITAL   (Ireland)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

blood levels; human; MCPP; tradozone

Indexed keywords

TRAZODONE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; SEROTONIN AGONISTS; TRAZODONE;

EID: 0030965895     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00521-5     Document Type: Article

References (6)

1. Baran B, Maj J, Rogoz Z, et al (1979): On the central antiserotonin action of trazodone. Pol J Pharmacol 31:25-33.
2. Benjamin J, Greenberg J, Murphy DL (in press): Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects. Psychopharmacology.
3. Lawlor BA, Newhouse PA, Sunderland T, et al (1991): Effects of nighttime administration of the serotonin agonist, m-CPP on sleep architecture and behavior in healthy volunteers. Biol Psychiatry 29:281-286.
4. Maj J, Palider W, Rawlow (1979): Trazodone, a central serotonin antagonist and agonist. J Neural Transm Gen Sect 44:237-248.
5. Murphy DL, Mueller EA, Hill JL, et al (1989): Comparative anxiogenic, neuroendocrine and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers. Psychopharmacology 98:275-282.
6. Sansone M, Melzacka M, Hano J, et al (1983): Reversal of depressant action of trazodone on avoidance behavior by its metabolite m-chlorophenylpiperazine. J Pharm Pharmacol 35:189-190.