메뉴 건너뛰기




Volumn 99, Issue 8, 1997, Pages 1958-1965

Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene

Author keywords

apolipoproteins; enhancer; high density lipoprotein; intestine; mutation; transcription factor

Indexed keywords

APOLIPOPROTEIN A1;

EID: 0030964911     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119363     Document Type: Article
Times cited : (25)

References (55)
  • 4
    • 0029115956 scopus 로고
    • Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4
    • Ginsburg, G.S., J. Ozer, and S.K. Karathanasis. 1995. Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. J. Clin. Invest. 96:528-538.
    • (1995) J. Clin. Invest. , vol.96 , pp. 528-538
    • Ginsburg, G.S.1    Ozer, J.2    Karathanasis, S.K.3
  • 5
    • 0026025868 scopus 로고
    • Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells
    • Widom, R.L., J.A.A. Ladias, S. Kouidou, and S.K. Karathanasis. 1991. Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells. Mol. Cell. Biol. 11:677-687.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 677-687
    • Widom, R.L.1    Ladias, J.A.A.2    Kouidou, S.3    Karathanasis, S.K.4
  • 6
    • 0023867608 scopus 로고
    • Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types
    • Sastry, K.N., U. Seedorf, and S.K. Karathanasis. 1988. Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types. Mol. Cell. Biol. 8:605-614.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 605-614
    • Sastry, K.N.1    Seedorf, U.2    Karathanasis, S.K.3
  • 7
    • 0027480041 scopus 로고
    • Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoC-III gene
    • Walsh, A., N. Azrolan, K. Wang, A. Marcigliano, A. O'Connell, and J.L. Breslow. 1993. Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoC-III gene. J. Lipid Res. 34:617-623.
    • (1993) J. Lipid Res. , vol.34 , pp. 617-623
    • Walsh, A.1    Azrolan, N.2    Wang, K.3    Marcigliano, A.4    O'Connell, A.5    Breslow, J.L.6
  • 8
    • 0021926221 scopus 로고
    • Apolipoprotein A-I synthesis in rat small intestine: Regulation by dietary triglyceride and biliary lipid
    • Davidson, N.O., and R.M. Glickman. 1985. Apolipoprotein A-I synthesis in rat small intestine: regulation by dietary triglyceride and biliary lipid. J. Lipid Res. 26:368-379.
    • (1985) J. Lipid Res. , vol.26 , pp. 368-379
    • Davidson, N.O.1    Glickman, R.M.2
  • 9
    • 0023204497 scopus 로고
    • Apolipoprotein A-IV synthesis in rat intestine: Regulation by dietary triglyceride
    • Apfelbaum, T.F., N.O. Davidson, and R.M. Glickman. 1987. Apolipoprotein A-IV synthesis in rat intestine: regulation by dietary triglyceride. Am. J. Physiol. 252:G662-G666.
    • (1987) Am. J. Physiol. , vol.252
    • Apfelbaum, T.F.1    Davidson, N.O.2    Glickman, R.M.3
  • 10
    • 0022461979 scopus 로고
    • Apolipoprotein B synthesis in rat small intestine: Regulation by dietary triglyceride and biliary lipid
    • Davidson, N.O., M.E. Kollmer, and R.M. Glickman. 1986. Apolipoprotein B synthesis in rat small intestine: regulation by dietary triglyceride and biliary lipid. J. Lipid Res. 27:30-39.
    • (1986) J. Lipid Res. , vol.27 , pp. 30-39
    • Davidson, N.O.1    Kollmer, M.E.2    Glickman, R.M.3
  • 11
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin, J.M., A.E. Przybyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.E.2    MacDonald, R.J.3    Rutter, W.J.4
  • 13
    • 0025309751 scopus 로고
    • Promoter elements and factors required for hepatic and intestinal transcription of the human apoCIII gene
    • Ogami, K., M. Hadzopoulou-Cladaras, C. Cladaras, and V.I. Zannis. 1990. Promoter elements and factors required for hepatic and intestinal transcription of the human apoCIII gene. J. Biol. Chem. 265:9808-9815.
    • (1990) J. Biol. Chem. , vol.265 , pp. 9808-9815
    • Ogami, K.1    Hadzopoulou-Cladaras, M.2    Cladaras, C.3    Zannis, V.I.4
  • 15
    • 0023649835 scopus 로고
    • CAT constructions with multiple unique restriction sites for functional analysis of eukaryotic promoter and regulatory elements
    • Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for functional analysis of eukaryotic promoter and regulatory elements. Nucleic Acids Res. 15:5490.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 5490
    • Luckow, B.1    Schutz, G.2
  • 16
    • 0022377642 scopus 로고
    • Cell-specific expression of the rat insulin gene: Evidence for role of two distinct 5′ flanking elements
    • Edlund, T., M.D. Walker, P.J. Barr, and W.J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science (Wash. DC). 230:912-916.
    • (1985) Science (Wash. DC) , vol.230 , pp. 912-916
    • Edlund, T.1    Walker, M.D.2    Barr, P.J.3    Rutter, W.J.4
  • 18
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F.L., and A.J. Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Eb, A.J.2
  • 19
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 21
    • 0027223301 scopus 로고
    • An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphisms
    • Dammerman, M., L.A. Sandkuijl, J.L. Halaas, W. Chung, and J.L. Breslow. 1993. An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphisms. Proc. Natl. Acad. Sci. USA. 90:4562-4566.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4562-4566
    • Dammerman, M.1    Sandkuijl, L.A.2    Halaas, J.L.3    Chung, W.4    Breslow, J.L.5
  • 23
    • 0018291160 scopus 로고
    • Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat
    • Wu, A.L., and H.G. Windmueller. 1979. Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J. Biol. Chem. 254: 7316-7322.
    • (1979) J. Biol. Chem. , vol.254 , pp. 7316-7322
    • Wu, A.L.1    Windmueller, H.G.2
  • 24
    • 0015799823 scopus 로고
    • Biosynthesis of lymph and plasma lipoprotein apoproteins by isolated perfused rat liver and intestine
    • Windmueller, H.G., P.N. Herbert, and R.I. Levy. 1973. Biosynthesis of lymph and plasma lipoprotein apoproteins by isolated perfused rat liver and intestine. J. Lipid Res. 14:215-223.
    • (1973) J. Lipid Res. , vol.14 , pp. 215-223
    • Windmueller, H.G.1    Herbert, P.N.2    Levy, R.I.3
  • 25
    • 0019491978 scopus 로고
    • Biosynthesis of plasma apolipoproteins by rat small intestine without dietary or biliary fat
    • Windmueller, H.G., and A.L. Wu. 1981. Biosynthesis of plasma apolipoproteins by rat small intestine without dietary or biliary fat. J. Biol. Chem. 256: 3012-3016.
    • (1981) J. Biol. Chem. , vol.256 , pp. 3012-3016
    • Windmueller, H.G.1    Wu, A.L.2
  • 26
    • 0022556155 scopus 로고
    • High-density lipoprotein formation by the intestine
    • Glickman, R.M., and A.M. Magun. 1986. High-density lipoprotein formation by the intestine. Methods Enzymol. 129:519-536.
    • (1986) Methods Enzymol. , vol.129 , pp. 519-536
    • Glickman, R.M.1    Magun, A.M.2
  • 27
    • 0026057848 scopus 로고
    • Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses
    • Rubin, E.M., B.Y. Ishida, S.M. Clift, and R.M. Krauss. 1991. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses. Proc. Natl. Acad. Sci. USA. 88:434-438.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 434-438
    • Rubin, E.M.1    Ishida, B.Y.2    Clift, S.M.3    Krauss, R.M.4
  • 28
    • 0024592946 scopus 로고
    • High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3
    • Walsh, A., Y. Ito, and J.L. Breslow. 1989. High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J. Biol. Chem. 264:6488-6494.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6488-6494
    • Walsh, A.1    Ito, Y.2    Breslow, J.L.3
  • 29
    • 0028931330 scopus 로고
    • Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription
    • Kilbourne, E.J., R. Widom, D.C. Harnish, S. Malik, and S.K. Karathanasis. 1995. Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription. J. Biol. Chem. 270:7004-7010.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7004-7010
    • Kilbourne, E.J.1    Widom, R.2    Harnish, D.C.3    Malik, S.4    Karathanasis, S.K.5
  • 30
    • 0025875141 scopus 로고
    • A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways
    • Rottman, J.N., R.L. Widom, D. Nadal-Ginard, V. Mahdavi, and S.K. Karathanasis. 1991. A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways. Mol. Cell. Biol. 11:3814-3820.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3814-3820
    • Rottman, J.N.1    Widom, R.L.2    Nadal-Ginard, D.3    Mahdavi, V.4    Karathanasis, S.K.5
  • 31
    • 0028061943 scopus 로고
    • Activation of apolipoprotein AI gene transcription by the liver-enriched factor HNF-3
    • Harnish, D.C., S. Malik, and S.K. Karathanasis. 1994. Activation of apolipoprotein AI gene transcription by the liver-enriched factor HNF-3. J. Biol. Chem. 269:28220-28226.
    • (1994) J. Biol. Chem. , vol.269 , pp. 28220-28226
    • Harnish, D.C.1    Malik, S.2    Karathanasis, S.K.3
  • 32
    • 0027278675 scopus 로고
    • Increased expression of apolipoprotein genes accompanies differentiation in the intestinal cell line Caco-2
    • Reisher, S.R., T.E. Hughes, J.M. Ordovas, E.J. Schaefer, and S.I. Feinstein. 1993. Increased expression of apolipoprotein genes accompanies differentiation in the intestinal cell line Caco-2. Proc. Natl. Acad. Sci. USA. 90:5757-5761.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5757-5761
    • Reisher, S.R.1    Hughes, T.E.2    Ordovas, J.M.3    Schaefer, E.J.4    Feinstein, S.I.5
  • 33
    • 0029149963 scopus 로고
    • Characterization of an enhancer element in the human apolipoprotein C-III gene that regulates human apolipoprotein A-I gene expression in the intestinal epithelium
    • Bisaha, J.G., T.C. Simon, J.I. Gordon, and J.L. Breslow. 1995. Characterization of an enhancer element in the human apolipoprotein C-III gene that regulates human apolipoprotein A-I gene expression in the intestinal epithelium. J. Biol. Chem. 270:19979-19988.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19979-19988
    • Bisaha, J.G.1    Simon, T.C.2    Gordon, J.I.3    Breslow, J.L.4
  • 34
    • 0023926909 scopus 로고
    • Apolipoprotein (apo) AI production and mRNA abundance explain plasma apoAI and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia
    • Sorci-Thomas, M., M.M. Prack, N. Dashti, F. Johnson, L.L. Rudel, and D.L. Williams. 1988. Apolipoprotein (apo) AI production and mRNA abundance explain plasma apoAI and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia. J. Biol. Chem. 263:5183-5189.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5183-5189
    • Sorci-Thomas, M.1    Prack, M.M.2    Dashti, N.3    Johnson, F.4    Rudel, L.L.5    Williams, D.L.6
  • 35
    • 0025950961 scopus 로고
    • Transcriptional regulation of the apolipoprotein AI gene
    • Sorci-Thomas, M., and M.W. Kearns. 1991. Transcriptional regulation of the apolipoprotein AI gene. J. Biol. Chem. 266:18045-18050.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18045-18050
    • Sorci-Thomas, M.1    Kearns, M.W.2
  • 36
    • 0024425420 scopus 로고
    • Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein AI gene: Relationships to plasma concentration of high density lipoproteins
    • Sorci-Thomas, M., M.M. Prack, N. Dashti, F. Johnson, L.L. Rudel, and D.L. Williams. 1989. Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein AI gene: relationships to plasma concentration of high density lipoproteins. J. Lipid Res. 30:1397-1403.
    • (1989) J. Lipid Res. , vol.30 , pp. 1397-1403
    • Sorci-Thomas, M.1    Prack, M.M.2    Dashti, N.3    Johnson, F.4    Rudel, L.L.5    Williams, D.L.6
  • 37
    • 0342280576 scopus 로고
    • Biphasic effects of estrogen on apolipoprotein synthesis in human hepatoma cells: Mechanisms of antagonism by testosterone
    • Tam, S.P., T.K. Archer, and R.G. Deeley. 1986. Biphasic effects of estrogen on apolipoprotein synthesis in human hepatoma cells: mechanisms of antagonism by testosterone. Proc. Natl. Acad. Sci. USA. 83:3111-3115.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3111-3115
    • Tam, S.P.1    Archer, T.K.2    Deeley, R.G.3
  • 38
    • 0008138455 scopus 로고
    • Expression of rat apolipoprotein A-IV and A-I genes: MRNA induction during development and in response to glucocorticoids and insulin
    • Elshourbagy, N.A., M.S. Boguski, W.S. Liao, L.S. Jefferson, J.I. Gordon, and J.M. Taylor. 1985. Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin. Proc. Natl. Acad. Sci. USA. 82:8242-8246.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 8242-8246
    • Elshourbagy, N.A.1    Boguski, M.S.2    Liao, W.S.3    Jefferson, L.S.4    Gordon, J.I.5    Taylor, J.M.6
  • 39
    • 0026638776 scopus 로고
    • Polymorphism in the human apolipoprotein A-I gene promoter region
    • Smith, J.D., E.A. Brinton, and J.L. Breslow. 1992. Polymorphism in the human apolipoprotein A-I gene promoter region. J. Clin. Invest. 89:1796-1800.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1796-1800
    • Smith, J.D.1    Brinton, E.A.2    Breslow, J.L.3
  • 40
    • 0027255977 scopus 로고
    • Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (apo) AI
    • Hayek, T., Y. Ito, N. Azrolan, R.B. Verdery, K. Aalto-Setala, A. Walsh. and J.L. Breslow. 1993. Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (apo) AI. J. Clin. Invest. 91:1665-1671.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1665-1671
    • Hayek, T.1    Ito, Y.2    Azrolan, N.3    Verdery, R.B.4    Aalto-Setala, K.5    Walsh, A.6    Breslow, J.L.7
  • 41
    • 0024992665 scopus 로고
    • Transcriptional and post-transcriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states
    • Panduro, A., Y.C. Lin-Lee, L. Chanand, and D. A. Shafritz. 1990. Transcriptional and post-transcriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. Biochemistry. 29:8430-8435.
    • (1990) Biochemistry , vol.29 , pp. 8430-8435
    • Panduro, A.1    Lin-Lee, Y.C.2    Chanand, L.3    Shafritz, D.A.4
  • 42
    • 0026660195 scopus 로고
    • Apolipoprotein AI expression and high density lipoprotein distribution in transgenic mice during development
    • Golder-Novoselsky, E., T.M. Forte, A.V. Nichols, and E.M. Rubin. 1992. Apolipoprotein AI expression and high density lipoprotein distribution in transgenic mice during development. J. Biol. Chem. 267:20787-20790.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20787-20790
    • Golder-Novoselsky, E.1    Forte, T.M.2    Nichols, A.V.3    Rubin, E.M.4
  • 44
    • 0028881810 scopus 로고
    • Common genetic variation in the promoter of the human apoCIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia
    • Li, W.W., M.M. Dammerman, J.D. Smith, S. Metzger, J.L. Breslow, and T. Leff. 1995. Common genetic variation in the promoter of the human apoCIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J. Clin. Invest. 96:2601-2605.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2601-2605
    • Li, W.W.1    Dammerman, M.M.2    Smith, J.D.3    Metzger, S.4    Breslow, J.L.5    Leff, T.6
  • 45
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven, G.M. 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 46
    • 0025030698 scopus 로고
    • Hypertriglyceridemia as a result of human apoCIII gene expression in transgenic mice
    • Ito, Y., N. Azrolan, A. O'Connell, A. Walsh, and J.L. Breslow. 1990. Hypertriglyceridemia as a result of human apoCIII gene expression in transgenic mice. Science (Wash. DC). 249:790-793.
    • (1990) Science (Wash. DC) , vol.249 , pp. 790-793
    • Ito, Y.1    Azrolan, N.2    O'Connell, A.3    Walsh, A.4    Breslow, J.L.5
  • 47
    • 0027948983 scopus 로고
    • A single-base substitution in the proximal Sp1 site of the human low density lipoprotein receptor promoter as a cause of heterozygous familial hypercholesterolemia
    • Koivisto, U.M., J.J. Palvimo, O.A. Jaennem, and K. Kontula. 1994. A single-base substitution in the proximal Sp1 site of the human low density lipoprotein receptor promoter as a cause of heterozygous familial hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 91:10526-10530.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10526-10530
    • Koivisto, U.M.1    Palvimo, J.J.2    Jaennem, O.A.3    Kontula, K.4
  • 48
    • 0029045344 scopus 로고
    • A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity
    • Yang, W., D.N. Nevin, R. Peng, J.D. Brunzell, and S.R. Deeb. 1995. A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity. Proc. Natl. Acad. Sci. USA. 92:4462-4466.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4462-4466
    • Yang, W.1    Nevin, D.N.2    Peng, R.3    Brunzell, J.D.4    Deeb, S.R.5
  • 49
    • 0028901713 scopus 로고
    • Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction
    • Eriksson, P., B. Kallin, P.M. van't hooft, P. Bavenholm, and A. Hamsten. 1995. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proc. Natl. Acad. Sci. USA. 92:1851-1855.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1851-1855
    • Eriksson, P.1    Kallin, B.2    Van't Hooft, P.M.3    Bavenholm, P.4    Hamsten, A.5
  • 50
    • 0029147735 scopus 로고
    • Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1
    • Beaty, J.S., K.A. West, and G.T. Nepom. 1995. Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol. Cell. Biol. 15:4771-4782.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4771-4782
    • Beaty, J.S.1    West, K.A.2    Nepom, G.T.3
  • 51
    • 0027972914 scopus 로고
    • Differential transcriptional activities of HLA-DR genes in the various haplotypes
    • Louis, P., R. Vincent, P. Cavadore, J. Clot, and J.F. Eliaou. 1994. Differential transcriptional activities of HLA-DR genes in the various haplotypes. J. Immunol. 153:5059-5067.
    • (1994) J. Immunol. , vol.153 , pp. 5059-5067
    • Louis, P.1    Vincent, R.2    Cavadore, P.3    Clot, J.4    Eliaou, J.F.5
  • 53
    • 0028177922 scopus 로고
    • The -158 (C→T) promoter mutation is responsible for the increased transcription of the 3′ gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin
    • Efremov, D.G., A.J. Dimovoski, and T.H.J. Huisman. 1994. The -158 (C→T) promoter mutation is responsible for the increased transcription of the 3′ gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin. Blood. 83:3350-3355.
    • (1994) Blood , vol.83 , pp. 3350-3355
    • Efremov, D.G.1    Dimovoski, A.J.2    Huisman, T.H.J.3
  • 54
    • 0025286228 scopus 로고
    • Distribution of a C/EBP binding site in the factor IX promoter is associated with haemophilia B
    • Crossley, M., and G.G. Brownlee. 1990. Distribution of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Nature (Lond.). 345:444-446.
    • (1990) Nature (Lond.) , vol.345 , pp. 444-446
    • Crossley, M.1    Brownlee, G.G.2
  • 55
    • 0029022349 scopus 로고
    • Three novel sequence variations in the 5′ upstream region of the cystic fibrosis transmembrane conductance regulator (CFTR) gene: Two polymorphisms and one putative molecular defect
    • Bienvenu, T., V. Lacronique, M. Raymondjean, C. Cazeneuve, D. Hubert, J.C. Kaplan, and C. Beldjord. 1995. Three novel sequence variations in the 5′ upstream region of the cystic fibrosis transmembrane conductance regulator (CFTR) gene: two polymorphisms and one putative molecular defect. Hum. Genet. 95:698-702.
    • (1995) Hum. Genet. , vol.95 , pp. 698-702
    • Bienvenu, T.1    Lacronique, V.2    Raymondjean, M.3    Cazeneuve, C.4    Hubert, D.5    Kaplan, J.C.6    Beldjord, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.