Behavioral effects of alprazolam in humans

Behavioural Pharmacology

Volumn 8, Issue 1, 1997, Pages 47-57

  Kelly, T H ^a   Foltin, R W ^b   Serpick, E ^c   Fischman, M W ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Columbia University ^*  (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Alprazolam; Humans; Learning; Performance; Subjective effects

Indexed keywords

ALPRAZOLAM;

ADULT; ARTICLE; BEHAVIOR; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MOOD; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RECOGNITION; RISK; SINGLE BLIND PROCEDURE; TASK PERFORMANCE; TIME PERCEPTION; VOLUNTEER;

EID: 0030964296     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199702000-00005     Document Type: Article

References (49)

1. Abernethy DR, Greenblatt DJ, Divoll M and Shader RI (1983) Pharmacokinetics of alprazolam. Journal of Clinical Psychiatry, 44, 45-47.
2. Allen D, Curran HV and Lader M (1991) The effects of repeated doses of clomipramine and alprazolam on physiological, psychomotor and cognitive functions in normal subjects. European Journal of Clinical Pharmacology, 40, 355-362.
3. Aranko K (1985) Task-dependent development of cross-tolerance to psychomotor effects of lorazepam in man. Acta Pharmacologia et Toxicologia, 56, 373-381.
4. Aranko K, Mattila MJ, Bordignon D (1985) Psychomotor effects of alprazolam and diazepam during acute and subacute treatment, and during the follow-up phase. Acta Pharmacologia et Toxicologia, 53, 364-372.
5. Bickel WK, Hughes JR and Higgins ST (1990) Human behavioral pharmacology of benzodiazepines: Effects on repeated acquisition and performance of response chains. Drug Development Research, 20, 53-65.
6. Bickel WK, Higgins ST and Hughes JR (1991) The effects of diazepam and trizolam on repeated acquisition and performance of response sequences with an observing response. Journal of the Experimental Analysis of Behavior, 56, 217-237.
7. Blom MW, Bartel PR, de Sommers K, Van der Meyden CH and Becker PJ (1990) The effects of alprazolam, quazepam and diazepam on saccadic eye movements, parameters of psychomotor function and the EEG. Fundamental Clinical Pharmacology, 4, 653-661.
8. Breier A, Davis OR and Buchanan RW (1991) Alprazolam attenuates metabolic stress-induced neuroendocrine and behavioral effects in humans. Psychopharmacology, 104, 479-484.
9. Busto U and Sellers EM (1991) Pharmacologic aspects of benzodiazepine tolerance and dependence. Journal of Substance Abuse Treatment, 8, 29-33.
10. Danjou P, Warot D, Hergueta T, Lacomblez L, Bouhours P and Puech AJ (1992) Comparative study of the psychomotor and antistress effects of ritanserin, alprazolam and diazepam in healthy subjects: Some trait anxiety-independent responses. International Clinical Psychopharmacology, 7, 73-79.
11. Ellinwood Jr EH, Heatherly DG, Nikaido AM, Bjornsson TD and Kilts C (1985) Comparative pharmacokinetics and pharmacodynamics of lorazepam, alprazolam and diazepam. Psychopharmacology, 86, 392-399.
12. Ellinwood EH, Nikaido AM and Heatherly DG (1987) Comparative pharmacodynamics of benzodiazepines. Clinical Pharmacology in Psychiatry, 3, 77-82.
13. Evans SM, Troisi JRI and Griffiths RR (1994) Tandospirone and alprazolam: Comparison of behavioral effects and abuse liability in humans. Journal of Pharmacology and Experimental Therapeutics, 271, 683-694.
14. Evans SM, Foltin RW, Levin FR and Fischman MW (1995) Behavioral and subjective effects of DN-2327 (pazinaclone) and alprazolam in normal volunteers. Behavioural Pharmacology, 6, 176-186.
15. Fawcett JA and Kravitz HM (1982) Alprazolam: pharmacokinetics, clinical efficacy, and mechanism of action. Pharmacotherapy, 2, 243-254.
16. Fischman MW (1977) The abuse potential of psychotropic drugs in man. In: Predicting Dependence Liability of Stimulant and Depressant Drugs (Eds T Thompson and KR Unna), pp. 261-284. University Park Press, Baltimore.
17. Fischman MW (1978) Cocaine and amphetamine effects on repeated acquisition in humans. Federation Proceedings, 37, 618.
18. Fleishaker JC, Garzone PD, Chambers JH, Sirocco K and Weingartner H (1995) Comparison of the spectrum of cognitive effects of alprazolam and adinazolam after single doses in healthy subjects. Psychopharmacology, 120, 169-176.
19. Frei A, Mollenkopf W and Gaertner HJ (1988) Sedative action of alprazolam and diazepam as measured by EWL and two different flicker fusion methods. Psychopharmacology, 96s, 355.
20. Greenblatt DJ, Divol M and Shader RI (1983) Automated gas chromatographic determination of plasma alprazolam concentrations. Journal of Clinical Psychopharmacology, 3, 366-368.
21. Greenblatt DJ, Harmatz JS, Dorsey C and Shader RI (1988) Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. Clinical Pharmacology and Therapeutics, 44, 326-334.
22. Hart RP, Colenda CC and Hamer RM (1991) Effects of buspirone and alprazolam on the cognitive performance of normal elderly subjects. American Journal of Psychiatry, 148, 73-77.
23. Higgins ST, Bickel WK, O'Leary DK and Yingling J (1987) Acute effects of ethanol and diazepam on the acquisition and performance of response sequences in humans. Journal of Pharmacology and Experimental Therapeutics, 243, 1-8.
24. Hindmarch I (1983) Measuring the side-effects of psychoactive drugs: A pharmacodynamic profile of alprazolam. Alcohol and Alcoholism, 18, 361-367.
25. Kelly TH, Foltin RW, Rose AJ, Fischman MW and Brady JV (1990) Smoked marijuana effects on tobacco cigarette smoking behavior. Journal of Pharmacology and Experimental Therapeutics, 252, 934-944.
26. Kelly TH, Foltin RW and Fischman MW (1991) The effects of repeated amphetamine exposure on multiple measures of human behavior. Pharmacology, Biochemistry and Behavior, 38, 417-426.
27. Kelly TH, Foltin RW, King L and Fischman MW (1992) Behavioral response to diazepam in a residential laboratory. Biological Psychiatry, 31, 808-822.
28. Kelly TH, Foltin RW and Fischman MW (1993) Effects of smoked marijuana on heart rate, drug ratings and task performance by humans. Behavioural Pharmacology, 4, 167-178.
29. Kroboth PD, Smith RB and Erb RJ (1988) Tolerance to alprazolam after intravenous bolus and continuous infusion: Psychomotor and EEG effects. Clinical Pharmacology and Therapeutics, 43, 270-277.
30. Lasher TA, Fleishaker JC, Steenwyk RC and Antal EJ (1991) Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine. Psychopharmacology, 104, 323-327.
31. Linnoila M, Stapleton JM, Lister R, Moss H, Lane E, Granger A and Eckardt MJ (1990) Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers. European Journal of Clinical Pharmacology, 39, 21-28.
32. Lucki I, Kerr LA, Fridman RB, Schweizer E and Rickeis K (1990) Behavioral effects of alprazolam in chronic therapeutic users. In: Problems of Drug Dependence, 1989, NIDA Research Monograph Series 95 (Ed LS Harris), p. 464. U.S. Government Printing Office, Washington D.C.
33. McLeod DR, Griffiths RR, Bigelow GE and Yingling J (1982) An automated version of the Digit Symbol Substitution Test (DSST). Behavior Research Methods and Instrumentation, 14, 463-466.
34. Mumford GK, Evans SM, Fleishaker JC and Griffiths RR (1995a) Alprazolam absorption kinetics affects abuse liability. Clinical Pharmacology and Therapeutics, 57, 356-365.
35. Mumford GK, Rush CR and Griffiths RR (1995b) Abecarnil and alprazolam in humans: Behavioral, subjective and reinforcing effects. Journal of Pharmacology and Experimental Therapeutics, 272, 570-580.
36. Mumford GK, Rush CR and Griffiths RR (1995c) Alprazolam and DN-2327 (Pazinaclone) in humans: Psychomotor, memory, subjective, and reinforcing effects. Experimental and Clinical Psychopharmacology, 3, 39-48.
37. Pharmacy Times (1994) Top 200 drugs of 1993. April, 18-32.
38. Pharmacy Times (1996) Top 200 drugs of 1995. April, 28-36.
39. Physicians' Desk Reference (1996). Medical Economics Company at Montvale, NJ.
40. Roache JD and Griffiths RR (1985) Comparison of triazolam and pentobarbital: Performance impairment, subjective effects and abuse liability. Journal of Pharmacology and Experimental Therapeutics, 234, 120-133.
41. Roache JD and Griffiths RR (1987) Lorazepam and meprobamate dose effects in humans: Behavioral effects and abuse liability. Journal of Pharmacology and Experimental Therapeutics, 243, 978-988.
42. Seidel WF, Cohen SA, Wilson L and Dement WC (1985) Effects of alprazolam and diazepam on the daytime sleepiness of non-anxious subjects. Psychopharmacology, 87, 194-197.
43. Sellers EM, Circaulo DA, DuPont RL, Griffiths RR, Kosten TR, Romach MK and Woody GE (1993) Alprazolam and benzodiazepine dependence. Journal of Clinical Psychiatry, 54 (10S), 64-74.
44. Smith RB and Kroboth PD (1987) Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects. Psychopharmacology, 93, 105-112.
45. Smith RB, Kroboth PD, Vanderlugt JT, Phillips JP and Juhl RP (1984) Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration. Psychopharmacology, 84, 452-456.
46. Sternberg S (1966) High-speed scanning in human memory. Science, 153, 652-654.
47. Wettstein JG (1990) Unusual behavioral profile of alprazolam in squirrel monkeys. Journal of Pharmacology and Experimental Therapeutics, 253, 1070-1076.
48. Ward A, Kelly TH, Foltin RW and Fischman MW (1997) Effects of d-amphetamine on task performance and social behavior of humans in a residential laboratory. Experimental and Clinical Psychophannacology, 5, 130-136.
49. Winer BJ (1971) Statistical Principles in Experimental Design (2nd edn), McGraw-Hill, New York.