The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: Prolongation of the nucleation time

European Journal of Clinical Investigation

Volumn 27, Issue 5, 1997, Pages 387-391

  Gustafsson, U ^a   Wang, F H ^b   Axelson, M ^b   Kallner, A ^b   Sahlin, S ^a   Einarsson, K ^b  

^a DANDERYD HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ascorbic acid; bile acids and salts; cholelithiasis

Indexed keywords

ASCORBIC ACID; BILE ACID; CHOLESTEROL; CHOLIC ACID; DEOXYCHOLIC ACID; LATHOSTEROL; LITHOCHOLIC ACID; PHOSPHOLIPID; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; BILE ACID SYNTHESIS; CHOLECYSTECTOMY; CHOLESTEROL METABOLISM; CHOLESTEROL STONE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HUMAN; LIPID BLOOD LEVEL; LIPID COMPOSITION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REAL TIME ECHOGRAPHY; SUPPLEMENTATION; VITAMIN BLOOD LEVEL;

EID: 0030964209     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.1240670.x     Document Type: Article

References (34)

1. Holzbach RT, Marsh M, Olszewski M, Holan K. Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest 1973;52:1467-79.
2. Lamont JT, Carey MC. Cholesterol gallstone formation. 2. Pathobiology and pathomechanics. Prog Liver Dis 1992;10:165-91.
3. Holan KR, Holzbach RT, Hermann RE, Cooperman AM, Claffey WJ. Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology 1979;77:611-7.
4. Greene YJ, Harwood HJ, Jr., Stacpoole PW. Ascorbic acid regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in guinea pig liver. Biochim Biophys Acta 1985;834:134-8.
5. Ginter E. Cholesterol: vitamin C controls its transformation to bile acids. Science 1973;179:702-4.
6. Harris WS, Kottke BA, Subbiah MT. Bile acid metabolism in ascorbic acid-deficient guinea pigs. Am J Clin Nutr 1979;32: 1837-41.
7. Holloway DE, Rivers JM. Influence of chronic ascorbic acid deficiency and excessive ascorbic acid intake on bile acid metabolism and bile composition in the guinea pig. J Nutr 1981;111: 412-24.
8. Ginter E, Nemec R, Cerven J, Mikus L. Quantification of lowered cholesterol oxidation in guinea pigs with latent vitamin C deficiency. Lipids 1973;8:135-41.
9. Ginter E, Mikus L. Reduction of gallstone formation by ascorbic acid in hamsters. Experientia 1977;33:716-7.
10. Hemilä H. Vitamin C and plasma cholesterol. Crit Rev Food Sci Nutr 1992;32:33-57.
11. Simon JA. Ascorbic acid and cholesterol gallstones. Med Hypotheses 1993;40:81-4.
12. Pedersen L. Biliary lipids during vitamin C feeding in healthy persons. Scand J Gastroenterol 1975;10:311-4.
13. Duane WC, Hutton SW. Lack of effect of experimental ascorbic acid deficiency on bile acid metabolism, sterol balance, and biliary lipid composition in man. J Lipid Res 1983;24:1186-95.
14. Björkhem I, Miettinen T, Reihner E, Ewerth S, Angelin B, Einarsson K. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res 1987;28:1137-43.
15. Lund E, Sisfontes L, Reihner E, Björkhem I. Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand J Clin Lab Invest 1989;49:165-71.
16. Axelson M, Aly A, Sjövall J. Levels of 7 alpha-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man. FEBS Lett 1988;239:324-8.
17. Axelson M, Björkhem I, Reihner E, Einarsson K. The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man. FEBS Lett 1991;284: 216-8.
18. Trotman BW, Ostrow JD, Soloway RD. Pigment vs. cholesterol cholelithiasis: comparison of stone and bile composition. Am J Dig Dis 1974;19:585-90.
19. Whiting MJ, Down RH, Watts JMcK. Biliary crystals and granules, the cholesterol saturation index, and the prediction of gallstone type. Surg Gastroenterol 1982;1:17-21.
20. Vuilleumier J, Keck E. Fluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. J Micronutr Anal 1989;5:25-34.
21. Roda A, Festi D, Sama C et al. Enzymatic determination of cholesterol in bile. Clin Chim Acta 1975;64:337-41.
22. Rouser G, Sidney F, Akira Y. Two dimensional thin layer chromatography separation of polar lipids and determination of phospholipids by phosphorous analysis of spots. Lipids 1970;5: 494-6.
23. Fausa O, Skålhegg BA, Fausa O. Quantitative determination of bile acids and their conjugates using thin-layer chromatography and a purified 3alpha-hydroxysteroid dehydrogenase. Treatment of Crohn's disease and the sequelae of small intestinal resection. Scand J Gastroenterol 1974;9:249-54.
24. Carey MC. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978;19:945-55.
25. Angelin B, Einarsson K, Leijd B. Biliary lipid composition during treatment with different hypolipidaemic drugs. Eur J Clin Invest 1979;9:185-90.
26. Sahlin S, Ahlberg J, Angelin B, Reihner E, Einarsson K. Nucleation time of gall bladder bile in gall stone patients: influence of bile acid treatment. Gut 1991;32:1554-7.
27. Kallner A. Serum bile acids in man during vitamin C supplementation and restriction. Acta Med Scand 1977;202:283-7.
28. Peterson VE, Crapo PA, Weininger J, Ginsberg H, Olefsky J. Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements. Am J Clin Nutr 1975;28:584-7.
29. Ginter E. Chenodeoxycholic acid, gallstones and vitamin C: letter. N Engl J Med 1976;295:1260-1.
30. Dobson HM, Muir MM, Hume R. The effect of ascorbic acid on the seasonal variations in serum cholesterol levels. Scot Med J 1984; 29:176-82.
31. Björkhem I, Kallner A. Hepatic 7alpha-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs. J Lipid Res 1976;17:360-5.
32. Ginter E. Vitamin-C deficiency and gallstone formation. Lancet 1971;2:1198-9.
33. Bergman F, Curstedt T, Eriksson H, van der Linden W, Sjövall J. Gallstone formation in guinea pigs under different dietary conditions. Effect of vitamin C on bile acid pattern. Med Biol 1981; 59:92-8.
34. Tazuma S, Sasaki H, Mizuno S et al. Effect of ursodeoxycholic acid administration on nucleation time in human gallbladder bile. Gastroenterology 1989;97:173-8.