Ebselen (DR3305) ameliorates delayed cerebral vasospasm in a canine two- hemorrhage model

Neurological Research

Volumn 19, Issue 5, 1997, Pages 563-565

  Watanabe, Takashi ^a   Nishiyama, Makoto ^a   Hori, Tomokatsu ^a   Asano, Takao ^b   Shimizu, Takao ^c   Masayasu, Hiroyuki ^d  

^a TOTTORI UNIVERSITY   (Japan)

^b Department of Neurology   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d DAIICHI SANKYO CO   (Japan)

Author keywords

Arachidonate; Delayed vasospasm; Ebselen; Glutathione peroxidase; Lipoxygenase; SAH

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; DR 3305; EBSELEN; GLUTATHIONE PEROXIDASE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANGIOGRAPHY; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CONTROLLED STUDY; DOG; DRUG EFFECT; NONHUMAN; ORAL DRUG ADMINISTRATION; SUBARACHNOID HEMORRHAGE;

EID: 0030963636     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1997.11740859     Document Type: Article

References (9)

1. Asano T, Tanishima T, Sasaki T, et al. Possible participation of free radical reaction initiated by clot lysis in the pathogenesis of vasospasm after subarachnoid hemorrhage. In: Wilkins RH, ed. Cerebral Arterial Spasm. Baltimore: Williamsand Wilkins, 1981:pp. 190-201
2. Watanabe T, Asano T, Shimizu T, et al. Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm. J Neurochem 1988; 50: 1145-1150
3. Watanabe T, Asano T, Shimizu T. Arachidonic acid lipoxygenase products participate in the pathogenesis of delayed cerebral ischemia. In: Bazan NG, Braquet P, Ginsberg MD, eds. Neurochemical Correlates of Cerebral Ischemia, New York and London: Plenum Press, 1992: pp. 139-159
4. Müller A, Cadenas E, Graf P, et al. A novel biologically active seleno-organic compound-1, glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ-51 (Ebselen). Biochem Pharmaco 1984; 33: 3235-3239
5. Lowry OH, Rosebrough NJ, Farr AJ, et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275
6. Watanabe T, Sasaki T, Asano T, et al. Change in glutathione peroxidase and lipid peroxides in cerebrospinal fluid and serum after subarachnoid hemorrhage - with special reference to the occurrence of cerebral vasospasm. Neuro Med Chir 1988; 28: 645-649
7. 4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer. Prostaglandins 1986; 31: 1029-1048
8. Shimizu T, Watanabe T, Asano T, et al. Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoid hemorrhage. J Neurochem 1988; 51:1126-1131
9. Yokota M, Tani E, Maeda Y, et al. Effect of 5-lipoxygenase inhibitor on experimental delayed cerebral vasospasm. Stroke 1987; 18: 512-518