Picogram determination of a novel dopamine D4 receptor antagonist in human plasma and urine by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry

Journal of Chromatography B: Biomedical Applications

Volumn 691, Issue 1, 1997, Pages 77-85

  Chavez Eng, C M ^a   Constanzer, M L ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dopamine D4 receptor antagonists

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; DOPAMINE RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIQUID LIQUID EXTRACTION; MASS SPECTROMETER; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TECHNIQUE;

ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; MICROCHEMISTRY; PYRIDINES; PYRROLES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SENSITIVITY AND SPECIFICITY;

EID: 0030963579     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00395-7     Document Type: Article

References (19)

1. A. Carlsson, Fund. Am. J. Psych., 135 (1978) 164-173.
2. D.E. Casey, Psychopharmacology, 99 (1989) S47-S53.
3. J. Kane, G. Honigfeld, J. Singer and H. Meltzer, Arch. Gen. Psych., 45 (1988) 785-796.
4. P. Seeman, H.-C. Guan and H. Van Tol, Nature, 365 (1993) 441-445.
5. H. Van Tol, J. Bunzow, H.-C. Guan, R. Sunahara, P. Seeman, H. Niznik and O. Civelli, Nature, 350 (1991) 610-619.
6. H. Van Toi, C. Wu, H.-C. Guan, K. Ohara, J. Bunzow, O. Civelli, J. Kennedy, P. Seeman, H. Niznik and V. Jovanovic, Nature, 358 (1992) 149-152.
7. P. Seeman, Neuropsychopharmacology, 7 (1992) 261-284.
8. J.J. Kulagowski, H.B. Broughton, N.R. Curtis, P.D. Leeson, I.M. Mawer, M.P. Ridgill, R. Baker, F. Emms, S.B. Freedman, R. Marwood, S. Patel and C.I. Ragan, J. Med. Chem., submitted for publication.
9. M.L. Constanzer, C.M. Chavez and B.K. Matuszewski, J. Chromatogr. B, 658 (1994) 281-287.
10. M. Constanzer, C. Chavez and B. Matuszewski, J. Chromatogr. B, 666 (1995) 117-126.
11. C.M. Chavez, M.L. Constanzer and B.K. Matuszewski, J. Pharm. Biomed. Anal., 13 (1995) 1179-1184.
12. J. Zagrobelny, C. Chavez, M. Constanzer and B.K. Matuszewski, J. Pharm. Biomed. Anal., 13 (1995) 1215-1223.
13. J.D. Gilbert, T.F. Greber, J.D. Ellis, A. Barrish, T.V. Olah, C. Fernandez-Metzler, A.S. Yuan and C.J. Burke, J. Pharm. Biomed. Anal., 13 (1995) 937-950.
14. J.D. Gilbert, E.L. Hand, A.S. Yuan, T.V. Olah and T.R. Covey, Biol. Mass. Spectrom., 21 (1992) 63-68.
15. J.D. Gilbert, T.V. Olah, A. Barrish and T.F. Greber, Biol. Mass Spectrom., 21 (1992) 341-346.
16. K. Matsuura, M. Kuwano and H. Takashina, J. Chromatogr., 621 (1993) 173-180.
17. M. Kai, C. Takano, H. Nohta and Y. Ohkura, J. Chromatogr., 621 (1993) 181-187.
18. M.H. Allen and B.I. Shushan, LC-GC Mag., 11 (1993) 112-126.
19. J.D.-Y. Dru, M.L. Constanzer and B.K. Matuszewski, unpublished results.