CD8+ cytotoxic T lymphocytes of a cynomolgus macaque infected with simian immunodeficiency virus (SIV) mac32H-J5 recognize a nine amino acid epitope in SIV Gag p26

Journal of General Virology

Volumn 78, Issue 4, 1997, Pages 821-824

  Geretti, Anna Maria ^a,b   Hulskotte, Ellen G J ^a   Dings, Marlinda E M ^a   Van Baalen, Carel A ^a   Van Amerongen, Geert ^c   Osterhaus, Albert D M E ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAG PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SYNTHETIC PEPTIDE; VIRUS ANTIGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LYMPHOCYTE SUBPOPULATION; MACACA; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION; VIRUS IMMUNITY; VIRUS INFECTION;

EID: 0030963529     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-4-821     Document Type: Article

References (15)

1. Brander, C., Pichler, W. J. & Corradin, G. (1995). Identification of HIV protein-derived cytotoxic T lymphocytes (CTL) epitopes for their possible use as synthetic vaccine. Clinical and Experimental Immunology 101, 107-113.
2. Chen, Z, W., Shen, L., Miller, M. D., Ghim, S. H., Hughes, A. L. & Letvin, N. L. (1992). Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. Journal of Immunology 149, 4060-4066.
3. Desrosiers, R. (1990). The simian immunodeficiency viruses. Annual Review of Immunology 8, 557-578.
4. Franco, A., Ferrari, C., Sette, A. & Chisari, F. V. (1995). Viral mutations, TCR antagonism and escape from the immune response. Current Opinion in Immunology 7, 524-531.
5. + T lymphocytes following anti-Fab detachment from immunomagnetic beads. Journal of Immunological Methods 161, 129-133.
6. Geretti, A. M., Dings, M. E. M., van Els, C. A. C. M., van Baalen, C. A., Wijnholds, F. J., Borleffs, J. C. C. & Osterhaus, A. D. M. E. (1996). HIV-1 and EBV specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV-1 infected persons. Journal of Infectious Diseases 174, 34-45.
7. Hulskotte, E. G. J., Geretti, A. M., Siebelink, K. H., van Amerongen, G., Cranage, M. P., Rud, E. W., Norley, S. G., de Vries, P. & Osterhaus, A. D. M. E. (1995). Vaccine-induced virus-neutralizing antibodies and cytotoxic T cells do not protect macaques from experimental infection with simian immunodeficiency virus SIVmac 32H (J5). Journal of Virology 69, 6289-6296.
8. Letvin, N. L., Reimann, K. A., Yasutomi, Y., Ringler, D. J. & Yamamoto, Y. (1994). The SIVmac specific cytotoxic T lymphocyte response in the acutely infected rhesus monkey. Current Topics in Microbiology and Immunology 188, 175-184.
9. + T cell responses to simian immunodeficiency virus. Current Topics in Microbiology and Immunology 188, 161-173.
10. Myers, G., Wain-Hobson, S., Henderson, L. E., Korber, B., Jeang, K. & Pavlakis, G. N. (1994). Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic and Amino Acid Sequences. Los Alamos National Laboratory Data Base, Los Alamos, N. Mex., USA.
11. Rud, E. W., Cranage, M., Yon, J., Quirk, J., Ogilvie, L., Cook, N., Webster, S., Dennis, M. & Clarke, B. (1994). Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. Journal of General Virology 75, 529-543.
12. Van Baalen, C. A., Klein, M. R., Huisman, R. C., Dings, M. E. M., Kerkhof Garde, S. R., Geretti, A. M., Gruters, R., Van Els, C. A. C. M., Miedema, F. & Osterhaus, A. D. M. E. (1996). Fine specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1. Journal of General Virology 77, 1659-1665.
13. Van de Griend, R. J., van Krimpen, B. A., Bol. S. J., Thompson, A. & Bolhuis, R. L. (1984). Rapid expansion of human cytotoxic T cell clones: growth promotion by heat-labile serum component and by various types of feeder cells. Journal of Immunological Methods 66, 285-298.
14. Watkins, D. I. (1994). MHC of nonhuman primates. Current Topics in Microbiology and Immunology 188, 145-159.
15. Yasutomi, Y., Koenig, S., Woods, R. M., Madsen, J., Wassef, N. M., Alving, C. R., Klein, H. J., Nolan, T. E., Boots, L. J., Kessler, J. A., Emini, E. A., Conley, A. J. & Letvin, N. L. (1995). A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against cell-free simian immunodeficiency virus challenge. Journal of Virology 69, 2279-2284.