Determination of human NAT2 acetylator genotype by oligonucleotide ligation assay

BioTechniques

Volumn 22, Issue 4, 1997, Pages 682-690

  Bigler, Jeannette ^a   Chen, Chu ^a   Potter, John D ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINE; ARYLAMINE ACETYLTRANSFERASE; GENE PRODUCT; OLIGONUCLEOTIDE;

ACCURACY; ACETYLATION; ALLELE; ARTICLE; BLADDER CARCINOMA; COLON CARCINOMA; DNA DETERMINATION; GENOTYPE; HUMAN; HUMAN CELL; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ROBOTICS;

EID: 0030963431     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/97224st03     Document Type: Article

References (20)

1. Bell, D.A., J.A. Taylor, M.A. Butler, E.A. Stephens, J. Wiest, L.H. Brubaker, F.F. Kadlubar and G.W. Lucier. 1993. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow acetylator allele common in African-Americans. Carcinogenesis 14:1689-1692.
2. Blum, M., A. Demierre, D.M. Grant, M. Heim and U.A. Meyer. 1991. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc. Natl. Acad. Sci. USA 88:5237-5241.
3. Blum, M., D.M. Grant, W. McBride, M. Heim and U.A. Meyer. 1990. Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell Biol. 9:193-203.
4. Cascorbi, I., N. Drakoulis, J. Brockmöller, A. Maurer, K. Sperling and I. Roots. 1995. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated caucasian individuals: correlation with phenotypic activity. Am. J. Hum. Genet. 57:581-592.
5. Deguchi, T., M. Mashimo and T. Suzuki. 1990. Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver. J. Biol. Chem. 265:12757-12760.
6. Delahunty, C.M., W. Ankener, S. Brainerd, D.A. Nickerson and I.T. Mononen. 1995. Finnish-type aspartylglucosaminuria detected by oligonucleotide ligation assay. Clin. Chem. 41:59-61.
7. Doll, M.A., A.J. Fretland, A.C. Deitz and D.W. Hein. 1995. Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification. Anal. Biochem. 231:413-420.
8. Evans, D.A.P. 1992. N-Acetyltransferase, p. 95-178. In W. Kalow (Ed.), Pharmacogenetics of Drug Metabolism. Pergamon, New York.
9. Grant, D.M., M. Blum, A. Demierre and U.A. Meyer. 1989. Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation. Nucleic Acids Res. 17:3978
10. Hickman, D., A. Risch, J.P. Camilleri and E. Sim. 1992. Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants. Pharmacogenetics 2:217-226.
11. Lin, H.J., C.-Y. Han, B.K. Lin and S. Hardy. 1993. Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology. Am. J. Hum. Genet. 52:827-834.
12. Lin, H.J., C.-Y. Han, B.K. Lin and S. Hardy. 1994. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics 4:125-134.
13. Miller, S.A., D.D. Dykes and H.F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
14. Nickerson, D.A., R. Kaiser, S. Lappin, J. Stewart, L. Hood and U. Landegren. 1990. Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc. Natl. Acad. Sci. USA 87:8923-8927.
15. Ohsako, S. and T. Deguchi. 1990. Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver. J. Biol. Chem. 265:4630-4634.
16. Roots, I., N. Drakoulis and J. Brockmöller. 1992. Polymorphic enzymes and cancer risk: concepts, methodology and data review, p. 815-841. In W. Kalow (Ed.), Pharmacogenetics of Drug Metabolism. Pergamon, New York.
17. Rothman, N., R.B. Hayes, W. Bi, N. Caporaso, F. Broly, R.L. Woosley, S. Yin, P. Feng, X. You and U.A. Meyer. 1993. Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males. Pharmacogenetics 3:250-255.
18. Spurr, N.K., A.C. Gough, F.I. Chinegwundoh and C.A.D. Smith. 1995. Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk. Clin. Chem. 41:1864-1869.
19. Vatsis, K.P., K.J. Martell and W.W. Weber. 1991. Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc. Natl. Acad. Sci. USA 88:6333-6337.
20. Vatsis, K.P., W.W. Weber, D.A. Bell, J.M. Dupret, D.A. Evans, D.M. Grant, D.W. Hein, H.J. Lin et al. 1995. Nomenclature for N-acetyltransferases. Pharmacogenetics 5:1-17.