Dual inhibition of human leukocyte elastase and lipid peroxidation: In vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1906-1918

  Portevin, Bernard ^a   Lonchampt, Michel ^a   Canet, Emmanuel ^a   De Nanteuil, Guillaume ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[[[4 CHLORO 3 [[[[(4 HYDROXY 3,5 DI TERT BUTYLPHENYL) THIO]ACETYL]AMINO]SULFONYL]PHENYL]CARBONYL]AMINO] SULFONYL]BENZOYLVALYLPERHYDROINDOLE 2 CARBOXYLVALINE TRIFLUOROMETHYL KETONE; ELASTASE INHIBITOR; LEUKOCYTE ELASTASE; N [4 [(4 CHLOROPHENYLSULFONYL)AMINOCARBONYL]BENZOYL]VALYLPROLYLVALYL TRIFLUOROMETHYL KETONE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; EMPHYSEMA; ENZYME INHIBITION; LIPID PEROXIDATION; MALE; NONHUMAN; SYRIAN HAMSTER;

ANIMALS; ANTIOXIDANTS; CRICETINAE; ENZYME INHIBITORS; HEMORRHAGE; HUMANS; LEUKOCYTE ELASTASE; LIPID PEROXIDATION; LUNG DISEASES; MALE; MESOCRICETUS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OLIGOPEPTIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030963186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960772z     Document Type: Article

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