Small GTP-binding protein, Rab6, is associated with secretory granules in atrial myocytes

American Journal of Physiology - Cell Physiology

Volumn 272, Issue 5 41-5, 1997, Pages

  Iida, Hiroshi ^a   Tanaka, Shigeyasu ^b   Shibata, Yosaburo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

atrial granules; immunocytochemistry; secretion; secretory pathway; vesicular transport

Indexed keywords

ENZYME PRECURSOR; GUANINE NUCLEOTIDE BINDING PROTEIN; RAB PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; INTRACELLULAR TRANSPORT; MEMBRANE VESICLE; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; RAT; SECRETORY GRANULE;

ANIMALIA; EUKARYOTA;

EID: 0030962679     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.272.5.c1594     Document Type: Article

References (19)

1. Antony, C., C. Cibert, G. Geraud, A. Santa Maria, B. Maro, V. Mayau, and B. Goud. The small GTP-binding protein rab6p is distributed from medial Golgi to the trans-Golgi network as determined by a confocal microscopic approach. J. Cell Sci. 103: 785-796, 1992.
2. Chavrier, P., M. Vingron, C. Sander, K. Simons, and M. Zerial, Molecular cloning of YPT1/SEC4-related cDNA from an epithelial cell line. Mol. Cell. Biol. 10: 6578-6585, 1990.
3. DeBold, A. J. Atrial natriuretic factor: a hormone produced by the heart. Science 230: 767-770, 1985.
4. De Camilli, P., S. M. Harris, W. B. Huttner, and P. Greengard. Synapsin I (protein I), a novel terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J. Cell Biol. 96: 1355-1373, 1983.
5. Deretic, D., and D. S. Papermaster. Rab6 is associated with a compartment that transports rhodopsin from the trans-Golgi to the site of rod outer segment disk formation in retinal photoreceptors. J. Cell Sci. 106: 803-813, 1993.
6. Gorvel, J., P. Chavrier, M. Zerial, and J. Gruenberg. Rab5 controls early endosome fusion in vitro. Cell 64: 915-925, 1991.
7. Goud, B., A. Zahraoui, A. Tavitian, and J. Saraste. Small GTP-binding protein associated with Golgi cisternae. Nature 345: 553-556, 1990.
8. Haubruck, H., R. Prange, C. Vorgias, and D. Gallwitz. The ras-related mouse ypt1 protein can functionally replace the YPT1 gene product in yeast. EMBO J. 8: 1427-1432, 1989.
9. Huber, L. A., M. J. de Hoop, P. Dupree, M. Zerial, K. Simons, and C. Dotti. Protein transport to the dendritic plasma mem-brane of cultured neurons is regulated by rab8p. J. Cell Biol. 123: 47-55, 1993.
10. Huber, L. A., S. Pimplikar, R. G. Parton, H. Virta, M. Zerial, and K. Simons. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J. Cell Biol. 123: 35-45, 1993.
11. Iida, H., and Y. Shibata. Phasic secretion of newly synthesized atrial natriuretic factor from unstimulated atrial myocytes in culture. Circ, Res. 74: 659-668, 1994.
12. Iida, H., L. Wang, K. Nishii, A. Ookuma, and Y. Shibata. Identification of rab12 as a secretory granule-associated small GTP-binding protein in atrial myocytes. Circ. Res. 78: 343-347, 1996.
13. Jones, S. M., J. R. Crosby, J. Salamero, and K. E. Howell. A cytosolic complex of p62 and rab6 is associated with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network. J. Cell Biol. 122: 775-788, 1993.
14. 32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C. Proc. Natl. Acad. Sci. USA 84: 2261-2265, 1987.
15. Lombardi, D., T. Soldati, M. A. Riederer, Y. Goda, M. Zerial, and S. R. Pfeffer. Rab9 functions in transport between late endosomes and the trans-Golgi network. EMBO J. 12: 677-682, 1993.
16. Maconlogue, L., F. Castellano, C. deWit, D. Schenk, and W. A. Maltese. Differential effects of a rab6 mutant on secretory versus amyloidogenic processing of alzheimer's β-amyloid precursor protein. J. Biol. Chem. 271: 1343-1348, 1996.
17. Maniatis, T., E. F. Fritsch, and J. Sambrook. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
18. Martinez, O., A. Schmidt, J. Salamero, B. Hoflack, M. Roa, and B. Goud. The small GTP-binding protein rab6 functions in intra-Golgi transport. J. Cell Biol. 127: 1575-1588, 1994.
19. Oka, T., and A. Nakano. Inhibition of GTP hydrolysis by Sarlp causes accumulation of vesicles that are a functional intermediate of the ER-to-Golgi transport in yeast. J. Cell Biol. 124: 425-434, 1994.