Prohibitin: A new biomarker for breast tumors

Breast Journal

Volumn 3, Issue 2, 1997, Pages 85-89

  Dell'Orco, Robert T ^a   Jupe, Eldon R ^a   Manjeshwar, Sharmila ^a   Liu, Xiao T ^a   McClung, J Keith ^a   King, Robert ^a   Hollingsworth, Alan ^b   Lightfoot, Stan ^b   Kern, William ^b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

biomarker; breast tumors; overexpression; prohibitin

Indexed keywords

BIOLOGICAL MARKER; PROHIBITIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST CARCINOMA; BREAST HYPERPLASIA; BREAST TUMOR; CARCINOMA IN SITU; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; PROTEIN EXPRESSION;

EID: 0030962476     PISSN: 1075122X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1524-4741.1997.tb00147.x     Document Type: Article

References (8)

1. Bernstam VA. Handbook of Gene Level Diagnostics in Clinical Practice. Boca Raton: CRC Press, 1992.
2. Jupe ER, Liu X-T, Kiehlbauch JL, McClung JK, Dell'Orco RT. Prohibitin in breast cancer cell lines: antiproliferative activity is linked to 3′ untranslated region mutations. Cell Growth Differ 1996;7:871-78.
3. McClung JK, Jupe ER, Liu X-T, Dell'Orco RT. Prohibitin: potential role in senescence, development, and tumor suppression. Exp Gerontol 1995;30:99-124.
4. White JJ, Ledbetter DH, Eddy RL Jr, et al. Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism. Genomics 1992;11: 228-30.
5. Sato T, Daito H, Swensen J, et al. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res 1992;52:1643-46.
6. Jupe ER, Liu X-T, Kiehlbauch JL, McClung JK, Dell'Orco RT. Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines. Exp Cell Res 1995; 218:577-80.
7. Jupe ER, Liu X-T, Kiehlbauch JL, McClung JK, Dell'Orco RT. The 3′ untranslated region of prohibitin and cellular immortalization. Exp Cell Res 1996;224:128-35.
8. Ikonen E, Fiedler K, Parton RG, Simons K. Prohibitin, an antiproliferative protein, is localized to mitochondria. FEBS Lett 1995;358:273-77.