Genistein, a protein tyrosine kinase inhibitor, ameliorates retinal degeneration after ischemia-repefusion injury in rat

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 6, 1997, Pages 1193-1202

  Hayashi, Atsushi ^a   Weinberger, Andreas W A ^a   Kim, Hyung Chan ^a   De Juan Jr , Eugene ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

genistein; ischemia repefusion injury; protein tyrosine phosphorylation; rat; retina

Indexed keywords

DIMETHYL SULFOXIDE; GENISTEIN; ISOFLAVONE; PROTEIN TYROSINE KINASE INHIBITOR; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE LIGATION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; RETINA DEGENERATION; RETINA ISCHEMIA;

ANIMALS; ENZYME INHIBITORS; EYE PROTEINS; GENISTEIN; ISCHEMIA; ISOFLAVONES; MALE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINA; RETINAL DEGENERATION; RETINAL VESSELS; TYROSINE;

EID: 0030962271     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Stefansson E, Wilson CA, Schoen T, Kuwabara T. Experimental ischemia induces cell mitosis in the adult rat retina. Invest Ophthalmol Vis Sci. 1988; 29:1050-1055.
2. Szabo ME, Droy-Lefaix MT, Doly M, Carre C, Braquet P. Ischemia and reperfusion-induced histologic changes in the rat retina. Invest Ophthalmol Vis Sci. 1991;32:1471-1478.
3. Louzada-Junior P, Dias JJ, Santos WF, Lachat JJ, Bradford HF, Coutinho-Netto J. Glutamate release in experimental ischaemia of the retina: An approach using microdialysis. J Neurochem. 1992;59:358-363.
4. Lombardi G, Moroni F, Moroni F. Glutamate receptor antagonists protect against ischemia-induced retinal damage. Eur J Pharmacol 1994; 271:489-495.
5. Takahashi K, Lam TT, Edward DP, Buchi ER, Tso MOM. Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol. 1992;110:862-870.
6. Weber M, Mohand-Said S, Hicks D, Dreyfus H, Sahel JA. Monosialoganglioside GM1 reduces ischemia-reperfusion-induced injury in the rat retina. Invest Ophthalmol Vis Sci. 1996; 37:267-273.
7. Unoki K, LaVail MM. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest Ophthalmol Vis Sci. 1994; 35:907-915.
8. Zhang C, Takahashi K, Lam TT, Tso MOM. Effects of basic fibroblast growth factor in retinal ischemia. Invest Ophthalmol Vis Sci. 1994;35:3163-3168.
9. Schlessinger J, Ullrich A. Growth factor signaling by receptor tyrosine kinases. Neuron. 1992;9:383-391.
10. Kazlauskas A. Receptor tyrosine kinases and their targets. Curr Opin Genet Dev. 1994;4:5-14.
11. Bading H, Greenberg ME. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science. 1991;253:912-253.
12. Fleming J, Fisslthaler B, Busse R. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases. Circ Res. 1995; 76:522-529.
13. Uckun FM, Tuel-Ahlgren L, Song CW, et al. Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death. Proc Natl Acad Sci USA. 1992;89:9005-9009.
14. Campos-Gonzalez R, Kindy MS. Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J Neurochem. 1992;59:1955-1958.
15. Yokota M, Saido TC, Miyaji K, et al. Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia. Neurosci Lett. 1994; 168:69-72.
16. Kindy MS. Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J Cereb Blood Flow Metab. 1993; 13:372-377.
17. Hayashi A, Koroma BM, Imai K, de Juan E Jr. Increase of protein tyrosine phosphorylation in rat retina after ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 1996; 37:2146-2156.
18. Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem. 1987; 262:5592-5595.
19. Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R, Schweigerer L. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr. 1995; 125:790S-797S.
20. Fotsis T, Pepper M, Adlercreutz H, et al. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci USA. 1993; 90:2690-2694.
21. Steele VE, Pereira MA, Sigman CC, Kelloff GJ. Cancer chemoprevention agent development strategies for genistein. J Nutr. 1995; 125:713S-716S.
22. Popovich K, Gaitan A, de Juan E Jr. Inhibition of protein tyrosine kinase by genistein: A novel approach to the inhibition of growth factor mediated tissue proliferation. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1991; 32:S834.
23. Koroma BM, de Juan E Jr. Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein. Biochem Pharmacol. 1994; 48:809-818.
24. Koroma BM, de Juan E Jr. Changes associated with tyrosine phosphorylation during short-term hypoxia in retinal microvascular endothelial cells in vitro. J Cell Biochem. 1995; 59:123-132.
25. Peterson G. Evaluation of the biochemical targets of genistein in tumor cells. J Nutr. 1995;125:784S-789S.
26. Constantinou A, Kiguchi K, Huberman E. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res. 1990; 50:2618-2624.
27. Linassier C, Pierre M, Le Peco JB, Pierre J. Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem Pharmacol. 1990; 39:187-193.
28. Jha HC, Recklinghausen GV, Zilliken F. Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids. Biochem Pharmacol. 1985; 34:1367-1369.
29. Wei H, Wei L, Frenkel K, Bowen R, Barnes S. Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutr Cancer. 1993; 20:1-12.
30. Hughes WR. Quantitation of ischemic damage in the rat retina. Exp Eye Res. 1991; 53:573-582.
31. Yousefi SA, Green DR, Blaser K, Simon HU. Proteintyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc Natl Acad Sci USA. 1994; 91:10868-10872.
32. Eldridge A, Kwolek WF. Soybean isoflavones: Effect of environment and variety on composition. J Agric Food Chem. 1983; 31:394-396.
33. Herman C, Adlercreutz T, Goldin BR, et al. Soybean phytoestrogen intake and cancer risk. J Nutr. 1995; 125:757S-770S.
34. Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet. 1993; 342:1209-1210.
35. Messina MJ, Persky V, Stechell KDR, Barnes S. Soy intake and cancer risk: A review of the in vitro and in vivo data. Nutr Cancer. 1994;21:113-131.
36. Akimaru K, Utsumi T, Sato EF, Klostergaard J, Inoue M, Utsumi K. Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-α and granulocyte colony stimulating factor. Arch Biochem Biophys. 1992; 298:703-709.
37. Utsumi T, Klostergaard J, Akimaru K, Edashige K, Sato EF, Utsumi K. Modulation of TNF-α priming and stimulation-dependent Superoxide generation in human neutrophils by protein kinase inhibitors. Arch Biochem Biophys. 1992; 294:271-278.
38. Tanimura M, Kobuchi H, Utsumi T, et al. Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors. Biochem Pharmacol 1992; 44:1045-1052.