The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 855-860

  Gassner, Beat ^a   Wüthrich, Andreas ^a   Scholtysik, Günter ^a   Solioz, Marc ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYHALOTHRIN; CYTOCHROME C OXIDASE; PERMETHRIN; PYRETHROID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME INHIBITION; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBMITOCHONDRIAL PARTICLE;

ANIMALS; INSECTICIDES; MALE; MITOCHONDRIA, LIVER; NAD(P)H DEHYDROGENASE (QUINONE); NITRILES; OXIDOREDUCTASES; OXYGEN; PERMETHRIN; PYRETHRINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030962116     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. ABBASSY, M. A., ELDEFRAWI, M. E. AND ELDEFRAWI, A. T.: Pyrethroid action on the nicotinic acetylcholine receptor/channel. Pestic. Biochem. Physiol. 19: 299-308, 1983.
2. BRENT, C. M.: Curve Fitting. In SigmaPlot for Scientists. pp. 130-156, Wm. C. Brown Publisher, London, 1995.
3. CASIDA, J. E., GAMMON, D. W., GLICKMAN, A. H. AND LAWRENCE, L. J.: Mechanisms of selective action of pyrethroid insecticides. Annu. Rev. Pharmacol. Toxicol. 23: 413-438, 1983.
4. CHEN, S. Y., ZHANG, Z. W., HE, F. S., YAO, P. P., WU, Y. Q., SUN, J. X., LIU, L. H. AND LI, Q. G.: An epidemiological study on occupational acute pyrethroid poisoning in cotton farmers. Br. J. Ind. Med. 48: 77-81, 1991.
5. DEGLI ESPOSTI, M., NGO, A. AND MYERS, M. A.: Inhibition of mitochondrial complex I may account for IDDM induced by intoxication with the rodenticide Vacor. Diabetes 45: 1531-1534, 1996.
6. DEVAUD, L. L. AND MURRAY, T. F.: Involvement of peripheral-type benzodiazepine receptors in the proconvulsant actions of pyrethroid insecticides. J. Pharmacol. Exp. Ther. 247: 14-22, 1988.
7. GHOSH, T. K.: Influence of cypermethrin on the oxidative metabolism of Iabeo rohita. Proc. Ind. Natl. Sci. Acad. B 55: 115-120, 1989.
8. HARTLEY, A., STONE, J. M., HERON, C., COOPKU, J. M. AND SCHAPIRA, A. H.: Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease. J. Neurochem. 63: 1987-1990, 1994.
9. HATEFI, Y. AND STIGGALL, D. L.: Preparation and properties of succinate: ubiquinone oxidoreductase (complex II). Methods Enzymol. 53: 21-27, 1978.
10. HOPPEL, C., DIMARCO, J. P. AND TANDLER, B.: Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states. J. Biol. Chem. 254: 4164-4170, 1979.
11. KADOUS, A., MATSUMURA, F. ANU ENAN, E.: High affinity binding of 3-verapamil to rat brain synaptic membrane is antagonized by pyrethroid insecticides. J. Environ. Sci. Health B 29: 855-871, 1994.
12. KRÄHENBÜHL, S., CHANG, M., BRASS, E. P. AND HOPPEL, C. L.: Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin(c-lactam)-induced methylmalonic aciduria. J. Biol. Chem. 266: 20998-21003, 1991.
13. LAWRENCE, L. J. AND CASIDA, J. E.: Stereospecific action of pyrethroid insecticidedes on the gamma-aminobutyric acid receptor-ionophore complex. Science 221: 1399-1401, 1983.
14. LEAHEY, J. P.: The Pyrethroid Insecticides, Taylor and Francis, London, 1985.
15. 2+)-ATPase. Biochim. Biophys. Acta 1028: 58-66, 1990.
16. MÜLLER-MOHNSSEN, H. AND HAHN, K.: Ueber eine Methode zur Früherkennung neurotoxischer Erkrankungen am Beispiel der Pyrethroidintoxikation. Gesundheitsw. 57: 214-222, 1995.
17. OORTGIESEN, M., VAN KLEEF, R. G. D. M. AND VIJVERBERG, H. P. M.: Effect of pyrethroids on neurotransmitter-operated ion channels in cultured mouse neuroblastoma cells. Pestic. Biochem. Physiol. 34: 164-173, 1989.
18. PECCI, L., MONTEFOSCHI, G., FONTANA, M. AND CAVALLINI, D.: Aminoethylcysteine ketimine decarboxylated dimer inhibits mitochondrial respiration by impairing electron transport at complex I level. Biochem. Biophys. Res. Commun. 199: 755-760, 1994.
19. RAGAN, C. I., WILSON, M. T., DARLEY-USMAR, V. M. AND LOWE, P. N.: Subfractionation of mitochondria and isolation of the proteins of oxidative phosphorylation. In Mitochondria: A Practical Approach, ed. by V. M. Darley-Usmar, D. Rickwood and M. T. Wilson, pp. 79-112, IRL Press, Oxford, 1987.
20. + ATPases in selected tissues of fish, Cyprinus carpio under fenvalerate toxicity. Biochem. Int. 23: 715-721, 1991.
21. REDDY, P. M. AND PHILIP, H.: Changes in the levels of respiration and ions in the tissues of freshwater fish, Labeo rohita under fenvalerate stress. Chemosphere 25: 843-852, 1992.
22. SCHULZ, J. B. AND BEAL, M. F.: Mitochondrial dysfunction in movement disorders. Curr. Opinion Neurol. 7: 333-339, 1994.
23. SCHWABE, R., BECKER, K., CLASS, T., ECKRICH, W., HOFFMANN, G., HOPPE, H. W., KRAUSE, C., PREISS, A., RIEGNER, K., SCHÄFFER, K., SCHULZ, C., STOLZ, P. AND WALKER, G.: Pyrethroide im Hausstaub. Eine Uebersicht WaBoLu Hefte 3: 1-111, 1994.
24. SEGEL, H. I.: Enzyme Kinetics. John Wiley & Sons, London, 1975.
25. SINGER, T. P.: Determination of the activity of succinate, NADH, choline, and alpha-glycerophosphate dehydrogenases. Methods Biochem Anal. 22: 123-175, 1974.
26. TATEBAYASHI, H. AND NARAHASHI, T.: Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J. Pharmacol. Exp. Ther. 270: 595-603, 1994.
27. TIPTON, K. F. AND SINGER, T. P.: Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem 61: 1191-1206, 1993.
28. VEITCH, K. AND HUE, L.: Flunarizine and cinnarizine inhibit mitochondr complexes I and II: Possible implication for parkinsonism. Mol. Pharmacol. 45: 158-163, 1994.
29. VIJVERBERG, H. P. M., VAN DER ZALM, J. M. AND VAN DEN BERCKEN, J.: Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves. Nature 295: 601-605, 1982.
30. VIJVERBERG, H. P. M. AND VAN DEN BERCKEN, J.: Neurotoxicological effects and the mode of action of pyrethroid insecticides. CRC Crit. Rev. Toxicol 21-105-126, 1990.